Current Status and Future Prospects of Proton MR Spectroscopy of the Breast with a 1.5T MR Unit

Proton MR spectroscopy of the mammary gland area is used to be considered in the realm of basic research, but as a result of the advances in MR techniques, it is now being performed in ordinary clinical practice. It is particularly noteworthy that useful clinical data are now being accumulated with 1.5T MR units, which are the standard units. We think that, at this point, it is very important to systematically review the techniques, clinical applications, and future prospects of proton MR spectroscopy. We have performed proton MR spectroscopy with a 1.5T MR unit in over 3000 cases at our hospital. In this paper, we will comment on the current status of proton MR spectroscopy of the breast, primarily in regard to differentiation between benign and malignant lesions and prediction of the efficacy of chemotherapy while describing the data obtained at our hospital.

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PHOTODYNAMIC THERAPY — AN UPDATE ON CLINICAL APPLICATIONS

Journal of Innovative Optical Health Sciences ◽

10.1142/s1793545809000401 ◽

2009 ◽

Vol 02 (01) ◽

pp. 73-92 ◽

Cited By ~ 12

Author(s):

ZHENG HUANG ◽

LIBO LI ◽

HONGWEI WANG ◽

XIULI WANG ◽

KAIHUA YUAN ◽

...

Keyword(s):

Photodynamic Therapy ◽

Clinical Application ◽

Clinical Data ◽

Basic Research ◽

Clinical Applications ◽

Review Article ◽

Malignant Diseases ◽

New Development ◽

The World ◽

Future Direction

Photodynamic therapy (PDT) has received increased attention since the regulatory approvals of several photosensitizers and light applicators in numerous countries and regions around the world. In recent years, much progress has been seen in basic research as well as clinical application. PDT clinical application has now extended from treating malignant diseases to nonmalignant diseases. This review article will present recent clinical data published in English journals. The data will be organized according to their clinical specialties. The new development and future direction in clinical applications of PDT for the management of both malignant and nonmalignant diseases will be discussed.

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Proton MR Spectroscopy–Detectable Major Neurotransmitters of the Brain: Biology and Possible Clinical Applications

American Journal of Neuroradiology ◽

10.3174/ajnr.a2587 ◽

2011 ◽

Vol 33 (4) ◽

pp. 595-602 ◽

Cited By ~ 28

Author(s):

N. Agarwal ◽

P.F. Renshaw

Keyword(s):

Mr Spectroscopy ◽

Clinical Applications ◽

Proton Mr Spectroscopy ◽

The Brain

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Proton MR spectroscopy in characterization of focal bone lesions of peripheral skeleton

Egyptian Journal of Radiology and Nuclear Medicine ◽

10.1186/s43055-019-0109-5 ◽

2019 ◽

Vol 50 (1) ◽

Author(s):

Meenu Amar ◽

Rohini Gupta Ghasi ◽

L. G. Krishna ◽

Geetika Khanna

Keyword(s):

Mr Spectroscopy ◽

Bone Lesions ◽

Water Suppression ◽

Low Grade ◽

Benign Lesions ◽

Giant Cell Tumors ◽

Proton Mr Spectroscopy ◽

Malignant Lesions ◽

Peripheral Skeleton ◽

Choline Peak

Abstract Background The aim of our study was to determine the value of single-voxel proton MR spectroscopy (1HMRS) in distinguishing benign from malignant focal bone lesions in the peripheral skeleton. MRI and 1HMRS was performed in 50 focal lesions (> 1 cm size) detected on radiographs of peripheral skeleton.1HMRS was performed at 1.5 T with TE of 144 ms with automatic shimming and water suppression. Qualitative analysis for a discrete choline peak at 3.2 ppm was done. Significance of the presence of choline peak on 1HMRS in distinguishing benign from malignant lesions was calculated using histopathology as a gold standard. Chi-square test was used and p value < 0.05 was considered significant. Results Forty-one benign and 9 malignant lesions were confirmed by histopathological results. Amongst malignant lesions, choline peak was positive in all but 1 case of low-grade lymphoma. MR spectra of 11 benign lesions showed the presence of choline peak. All 7 benign giant cell tumors (GCT) were positive for choline peak. The sensitivity, specificity, PPV, NPV of proton MR spectroscopy in differentiating benign from malignant lesions were 87.5%,71%,38.8%, and 96.4% respectively. p value was significant (< 0.05). Conclusion 1HMRS in focal bone lesions can help in the differentiation of malignant from benign musculoskeletal tumors. Although some benign lesions may show false-positive result, absence of choline peak is a reliable reassurance against malignancy. GCT is an exception amongst benign bone tumors as it consistently shows the presence of choline peak on 1HMRS.

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