scholarly journals A study of the different parameters in acute and chronic Budd–Chiari syndrome

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ramin Niknam ◽  
Nemattellah Hajizadegan ◽  
Vahid Mohammadkarimi ◽  
Laleh Mahmoudi
Keyword(s):  
Mortality Rate ◽  
Clinical Features ◽  
Spontaneous Bacterial Peritonitis ◽  
Meld Score ◽  
Hospital Length Of Stay ◽  
Budd Chiari Syndrome ◽  
Laboratory Parameters ◽  
Bacterial Peritonitis ◽  
Chronic Group ◽  
Chiari Syndrome

Abstract Background Budd–Chiari syndrome (BCS) is a rare and potentially life-threatening vascular disease of the liver. There are a few studies on the differences between acute and chronic BCS in clinical and laboratory characteristics, as well as the outcomes, so we designed this research to study the different parameters in acute and chronic BCS. Diagnosis of BCS was made using Doppler ultrasound, magnetic resonance imaging, and venography. Patients with BCS were then divided into chronic and acute groups based on both imaging characteristics and disease duration. Finally, the outcomes, clinical features, and laboratory parameters of acute and chronic BCS were compared. Results In total, 60 patients were included in this study, of whom 28.3% and 71.7% had acute and chronic BCS, respectively. According to clinical features, spontaneous bacterial peritonitis (PR 1.289; 95% CI 1.115–1.489; P = 0.001) and jaundice (PR 1.308; 95% CI 1.148–1.490; P < 0.001) were significantly associated with chronic than acute BCS. According to laboratory parameters, the levels of international normalized ratio (INR) (PR 0.953; 95% CI 0.918–0.989; P = 0.012), blood urea nitrogen (BUN) (PR 0.996; 95% CI 0.993–1.000; P = 0.039), and model for end-stage liver disease (MELD) score (PR 1.024; 95% CI 1.012–1.037; P < 0.001) in chronic group were significantly higher than in the acute BCS. The hospital length of stay (LOS) and mortality rate between the two groups did not differ significantly. Conclusions This study showed that the spontaneous bacterial peritonitis, jaundice, increased levels of MELD score, INR, and BUN were significantly associated with the chronic group compared with the acute group. The hospital LOS and mortality rate between the two groups did not differ significantly. Further research is recommended to clarify this issue.

Mo1002 MELD Score Is a Risk for First Episode of Spontaneous Bacterial Peritonitis in Patients With Cirrhosis

2014 ◽  
Vol 146 (5) ◽  
pp. S-983
Author(s):  
Rashid Khan ◽  
Whitney Jennings ◽  
Habeeb Salameh ◽  
Kirk Russ ◽  
Matthew J. Skinner ◽  
...  
Keyword(s):  
Spontaneous Bacterial Peritonitis ◽  
Meld Score ◽  
First Episode ◽  
Bacterial Peritonitis

Characteristic clinical features of hepatocellular carcinoma associated with Budd???Chiari syndrome

2004 ◽  
pp. 319-324 ◽  
Author(s):  
Sang Hyo Shin ◽  
Young-Hwa Chung ◽  
Dong Dae Suh ◽  
Jung Woo Shin ◽  
Myoung Kuk Jang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Features ◽  
Budd Chiari Syndrome ◽  
Chiari Syndrome

Diabetes mellitus at the time of diagnosis ofcirrhosis is associated with higher incidence of spontaneous bacterial peritonitis, but not with increased mortality

2013 ◽  
Vol 125 (7) ◽  
pp. 341-348 ◽  
Author(s):  
Nick Wlazlo ◽  
Marleen M. van Greevenbroek ◽  
Joyce Curvers ◽  
Erik J. Schoon ◽  
Pieter Friederich ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Platelet Count ◽  
Spontaneous Bacterial Peritonitis ◽  
Laboratory Data ◽  
Meld Score ◽  
Prognostic Impact ◽  
Bacterial Peritonitis ◽  
Increased Risk ◽  
End Stage

DM (diabetes mellitus) is present in 20–40% of patients with liver cirrhosis, but its prognostic impact is unclear. Therefore, in the present study, we investigated whether the presence of DM in patients with cirrhosis was associated with increased mortality, and/or with increased incidence of SBP (spontaneous bacterial peritonitis). We reviewed medical and laboratory data of 230 patients with cirrhosis from the period 2001–2011, for whom data were complete in n=226. Follow-up for the outcomes mortality and SBP was performed until May 2012, with only 13 patients lost to follow-up. DM was present at baseline in 78 patients (35%). Median follow-up was 6.2 (interquartile range, 3.1–9.3) years, during which 118 patients died [47 out of 78 with DM (60%), and 71 out of 148 without DM (48%)]. The presence of DM at baseline was not associated with increased mortality after adjustment for age {HR (hazard ratio), 1.00 [95% CI (confidence interval), 0.67–1.50]}. Further adjustment for sex, aetiology of cirrhosis, platelet count and the Child–Pugh or MELD (model for end-stage liver disease) score did not change this finding. During follow-up, 37 patients developed incident SBP (19 with DM and 18 without DM). DM at baseline was associated with incident SBP, even after adjustment for age, sex, aetiology, platelet count and the Child–Pugh [HR, 2.39 (95% CI, 1.10–5.18)] or MELD score [HR, 2.50 (95% CI, 1.16–5.40)]. In conclusion, the presence of DM at baseline in patients with cirrhosis was associated with an increased risk of SBP, which may represent an increased susceptibility to infections. On the other hand, DM was not clearly associated with increased mortality in these patients.

Predictive and Prognostic Value of Ascitic Fluid Mannose‑binding lectin in Patients with Spontaneous Bacterial Peritonitis

2020 ◽  
Vol 19 ◽  
Author(s):  
Amal A. Mohamed ◽  
Mohamed Abdelhamid ◽  
Naglaa El-Toukhy ◽  
Ahmed Sabry ◽  
Rania Abdelmonem Khattab ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Ascitic Fluid ◽  
Spontaneous Bacterial Peritonitis ◽  
Significant Negative Correlation ◽  
Meld Score ◽  
Mannose Binding Lectin ◽  
Bacterial Peritonitis ◽  
Mannose Binding ◽  
End Stage ◽  
Binding Lectin

Background/Aim: Spontaneous bacterial peritonitis is a common bacterial infection of ascitic fluid mainly in ascites due to liver cirrhosis. Mannose-binding lectin (MBL) can activate phagocytosis and the complement system. Spontaneous bacterial peritonitis was detected to be higher in MBL deficiency. This study aimed to assess ascitic fluid MBL in liver cirrhosis and spontaneous bacterial peritonitis. Methods: Ninety patients with cirrhotic ascites were included. Forty five of them had SBP. Child-Pugh score, Model for End Stage Liver Disease (MELD) and its update (uMELD) scores were used to assess severity of liver cirrhosis. Ascitic fluid samples were obtained for differentiation of leucocytic count, estimation of albumin, protein, glucose, and serumascitic albumin gradient. Ascitic fluid levels of MBL were measured for all patients. SBP was documented if polymorphonuclear leucocytic count ≥250/mm in ascitic fluid. Results: Ascitic fluid MBL level was significantly lower in patients with SBP. MBL had a significant negative correlation with ascitic total leukocytic count (TLC), also with serum creatinine, bilirubin, PT, INR and MELD score among SBP patients. However, it had a significant positive correlation with ascitic protein and with platelets. According to multivariate analysis; fever, TLC, platelets, creatinine, MBL, glucose and polymorphs were independent predictors for SBP development. Conclusion: Ascitic fluid MBL could be a good predictive and prognostic marker in patients with cirrhosis and spontaneous bacterial peritonitis.

Budd Chiari Syndrome in Children: Clinical Features, Radiological Intervention and Outcome Presidential Poster

2012 ◽  
Vol 107 ◽  
pp. S782
Author(s):  
Anshu Srivastava ◽  
Rachana Kathuria ◽  
Surender Yachha ◽  
Ujjal Poddar ◽  
Sanjay Baijal
Keyword(s):  
Clinical Features ◽  
Budd Chiari Syndrome ◽  
Chiari Syndrome ◽  
Radiological Intervention

An Uncommon Cause of Ascites: A Combination of Budd Chiari Syndrome and Secondary Bacterial Peritonitis in a Postpartum Patient

2018 ◽  
Vol 113 (Supplement) ◽  
pp. S1305
Author(s):  
Shanker D. Kundumadam ◽  
Lubna I. Fatiwala ◽  
Catherine Czesnowski ◽  
Manmeet Singh
Keyword(s):  
Budd Chiari Syndrome ◽  
Bacterial Peritonitis ◽  
Chiari Syndrome
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