Effect of vascular endothelial growth factor gene polymorphisms on disease activity in rheumatoid arthritis

Abstract Background The full etiology of RA remains unclear; in addition to the contributions of infectious, hormonal, and environmental factors, several lines of evidence have suggested that the disease has a genetic basis. The VEGF gene is also an independent risk factor for RA severity and correlates with multiple disease parameters, such as disease activity, joint damage, and functional disability. This case-control study aimed to investigate the impact of a common genetic polymorphism in the vascular endothelial growth factor (VEGF) gene on disease activity and synovial lesions in patients with rheumatoid arthritis (RA). Results T allele was present in the RA group more frequently (22.5% vs. 10% respectively in controls). The C allele was less frequent in the RA group (77.7% vs. 90% respectively in controls) (P = 0.002). Homozygous genotype (CC) was found in 61.2% of patients and 82.5% of controls, homozygous genotype (TT) in 6.3% of patients, and 2.5% of controls while heterozygous (CT) genotype in 32.5% of patients and 15% of controls (P = 0.011). Grade 1 PDUS was found in 30.6% of CC and 11.5% of CT and not found in TT genotypes. The grade 2 was found in 69.4%, 65.4%, and only 20% of CC, CT, and TT genotypes, respectively. The grade 3 was found in 80% of TT, 23.1% of CT, and none of CC genotypes (P < 0.001). Conclusion An association between VEGF gene SNP rs3025039 and increased risk for RA among a sample of Egyptian population was noticed. VEGF gene polymorphism appears to be a potential diagnostic activity indicator and a promising therapeutic target for RA patients.

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Polymorphism in the regulatory regions –С2578A and +C936T of the vascular endothelial growth factor (VEGF-A) gene in Russian women with rheumatoid arthritis

Terapevticheskii arkhiv ◽

10.17116/terarkh201789560-64 ◽

2017 ◽

Vol 89 (5) ◽

pp. 60-64 ◽

Cited By ~ 1

Author(s):

A V Shevchenko ◽

V F Prokofyev ◽

M A Korolev ◽

N E Banshchikova ◽

V I Konenkov

Keyword(s):

Rheumatoid Arthritis ◽

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Polymorphism Analysis ◽

Vascular Endothelial ◽

Vegf Gene ◽

Regulatory Regions ◽

Female Patients ◽

Healthy Women ◽

Endothelial Growth Factor

Aim. To analyze polymorphism in the regulatory regions of the vascular endothelial growth factor (VEGF) gene in female patients with rheumatoid arthritis (RA). Subjects and methods. The investigation enrolled 257 female patients with RA. A control group consisted of 297 women without chronic diseases. The investigators examined the single-nucleotide polymorphism of VEGF-А2578С in the promoter region (rs699947) and that of VEGF+С936Т 3 in the retranslated region (rs3025039) of the gene. Genotyping was performed by restriction fragment length polymorphism analysis. Results. There was an increase in the frequency of VEGF+936 CT and a reduction in that of the VEGF+936СС genotypes in the seronegative patients as compared to the healthy women. The VEGF+936СС genotype frequency was higher in the patients with seropositive RA than in the subgroup of seronegative patients. The frequency of the VEGF-2578СС genotype was increased in the patients with RA and rheumatoid nodules, as compared to the healthy women. Conclusion. The data presented suggest that the presence of certain VEGF gene variants located in the regulatory regions may reflect the nature of immunopathological mechanisms in RA.

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Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy

Modern Rheumatology ◽

10.3109/s10165-008-0125-1 ◽

2009 ◽

Vol 19 (1) ◽

pp. 12-19 ◽

Cited By ~ 197

Author(s):

Norihiro Nishimoto ◽

Nobuyuki Miyasaka ◽

Kazuhiko Yamamoto ◽

Shinichi Kawai ◽

Tsutomu Takeuchi ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Disease Activity ◽

Inadequate Response ◽

Vascular Endothelial ◽

Receptor Inhibition ◽

Endothelial Growth Factor ◽

Tocilizumab Monotherapy

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Elevated levels of vascular endothelial growth factor in the sera of patients with rheumatoid arthritis Correlation with disease activity

Life Sciences ◽

10.1016/s0024-3205(01)01264-4 ◽

2001 ◽

Vol 69 (16) ◽

pp. 1861-1869 ◽

Cited By ~ 39

Author(s):

Hirohito Sone ◽

Michihiro Sakauchi ◽

Akimitsu Takahashi ◽

Hiroaki Suzuki ◽

Noriyuki Inoue ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Disease Activity ◽

Vascular Endothelial ◽

Endothelial Growth Factor

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Polymorphism in the vascular endothelial growth factor A (VEGFA) gene is associated with serum VEGF-A level and disease activity in rheumatoid arthritis: Differential effect of cigarette smoking

Cytokine ◽

10.1016/j.cyto.2012.02.018 ◽

2012 ◽

Vol 58 (3) ◽

pp. 390-397 ◽

Cited By ~ 22

Author(s):

Ying Chen ◽

Peter T. Dawes ◽

Derek L. Mattey

Keyword(s):

Rheumatoid Arthritis ◽

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Cigarette Smoking ◽

Disease Activity ◽

Differential Effect ◽

Vascular Endothelial ◽

Endothelial Growth Factor ◽

Vegfa Gene

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Vascular Endothelial Growth Factor/Vascular Permeability Factor and VEGF Gene Polymorphisms is Detectable Rheumatoid Arthritis Patients

Indian Journal of Public Health Research & Development ◽

10.5958/0976-5506.2019.00179.7 ◽

2019 ◽

Vol 10 (1) ◽

pp. 924

Author(s):

Ishraq Abdul Ameer Salih ◽

Rabab Omran

Keyword(s):

Rheumatoid Arthritis ◽

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Vascular Permeability ◽

Gene Polymorphisms ◽

Vascular Endothelial ◽

Vegf Gene ◽

Vascular Permeability Factor ◽

Permeability Factor ◽

Endothelial Growth Factor

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A meta-analysis of the vascular endothelial growth factor polymorphisms associated with the risk of pre-eclampsia

Bioscience Reports ◽

10.1042/bsr20190209 ◽

2020 ◽

Vol 40 (5) ◽

Cited By ~ 1

Author(s):

Weicheng Duan ◽

Chenlu Xia ◽

Kang Wang ◽

Yijie Duan ◽

Ping Cheng ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Vascular Endothelial ◽

Vegf Gene ◽

Case Control Studies ◽

Increased Risk ◽

Subgroup Analyses ◽

Endothelial Growth Factor

Abstract Backgroud: Pre-eclampsia (PE) is a common pregnancy-induced hypertension disease. Some case–control studies reported the association between vascular endothelial growth factor (VEGF) gene polymorphisms (rs3025039, rs2010963) and PE risk. However, these associations were inconsistent in several studies. Therefore, we conducted this meta-analysis to assess the role of VEGF gene polymorphisms in PE more precisely. Methods: Eligible studies were searched in PubMed, Embase, Web of Science and Chinese (Chinese National Knowledge Infrastructure (CNKI) and WanFang) databases. Statistical analyses were performed by Stata 12.0 software. Odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of the association. In addition, subgroup analyses, sensitive analyses and publication bias analyses were performed to further assess this meta-analysis. Results: In total, 21 studies were included in the meta-analysis covering 2018 cases and 2632 controls. There were significant associations between VEGF polymorphisms (rs3025039, rs2010963) and PE risk in the overall populations. In the subgroup analyses, we found that rs3025039 polymorphism was associated with the increased risk of PE among Chinese. As for rs2010963 polymorphism, a significant association was observed in subgroup of Caucasian. Conclusion: The present study suggested that the two VEGF gene polymorphisms (rs3025039, rs2010963) are associated with increased risk of PE in different ethnic groups, which means that the targets may be useful genetic markers for early prediction of PE.

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