Platelet count as a predictor of outcome of hospitalized patients with community-acquired pneumonia at Zagazig University Hospitals, Egypt

Abstract Background This study was performed to evaluate the changing pattern of antibiotics usage among hospitalized patients of tertiary hospital in South Korea. Methods Total antibiotics prescription record of hospitalized patients from 2004 to 2013 were collected at a tertiary university hospitals. The antibiotics is defined as class J01 from anatomical therapeutic chemical classification system (ATC). The consumption of each class of antibiotic was converted to defined daily dose (DDD)/1,000 patient-days by using ATC of World Health Organization. Results Over the 10-year study period, the annual consumption of systemic antibiotics ranged from 815.10 to 1047.96. The proportion of broad-spectrum antibiotics and non-broad-spectrum antibiotics use are as follows: 45.4% (417.55/920.69) vs.. 54.6% (503.15/920.69), respectively. A 16.9% of decrease in total antibiotics consumption was observed in 2013 compared with 2004 (1000.69 in 2004 vs.. 831.46 in 2013). The decrease rate of non-broad spectrum antibiotics usage was 39.3% during the study period (607.21 in 2004 vs. 368.88 in 2013). In contrast, a stepwise increase in consumption of broad-spectrum antibiotics was observed (14.9% of increase; 393.48 in 2004 vs. 462.58 in 2013). Among broad-spectrum antibiotics, a significant decrease trend was observed for third-generation cephaloporins (P < 0.001). In contrast, a significant increase trend was observed for β-lactam/lactamase (P < 0.001). The monthly overall consumption trend of fluoroquinolones and glycopeptides remained stable (P = 0.061; P = 0.107, respectively). In addition, there were significant decrease trends for consumption of non-broad-spectrum antibiotics, including first generation cephalosporins (P = 0.019) and aminoglycosides (P = 0.004). However, the consumption of second generation cephalosporins, imidazole and penicillins showed a stable trend (P = 0.175; P = 320; P = 0.234, respectively). Conclusion A total antibiotics consumption showed significantly decrease trend from 2004 to 2013. In contrast, a stepwise increase in consumption of broad-spectrum antibiotics was observed in the tertiary hospital in South Korea. Disclosures All authors: No reported disclosures.

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Post Discharge Short Term Mortality in Hospitalized Patients with Community Acquired Pneumonia

Haydarpasa Numune Training and Research Hospital Medical Journal ◽

10.14744/hnhj.2020.05945 ◽

2020 ◽

Author(s):

Halit Çınarka

Keyword(s):

Community Acquired Pneumonia ◽

Hospitalized Patients ◽

Short Term ◽

Post Discharge ◽

Short Term Mortality

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Lymphocyte Count and Serum PCT L ev els Improve the Sensitivity of CURB-65 in Prediction of 30-day Mortality of Patients with Community-acquired Pneumonia

10.21203/rs.2.13741/v1 ◽

2019 ◽

Author(s):

Jin Zhang ◽

Rui Tao ◽

Pengcheng Liu ◽

Dahai Zhao ◽

Jiegou Xu

Keyword(s):

Logistic Regression ◽

Lymphocyte Count ◽

Scoring System ◽

Community Acquired Pneumonia ◽

Hospitalized Patients ◽

Diagnostic Model ◽

High Morbidity ◽

Operating Characteristics ◽

Blood Biomarkers ◽

Combined Models

Abstract Background Community-acquired pneumonia (CAP) is an infectious disease with high morbidity and mortality worldwide. The CURB-65 score and other blood biomarkers were used to evaluate prognosis of hospitalized patients with CAP. The aim of our study is t o evaluate the prognostic values of other blood biomarkers and the CURB-65 score in hospitalized patients with community-acquired pneumonia (CAP). Methods A retrospective study of clinical data of in-hospitalized adult CAP patients who fulfilled the CAP criteria and were admitted to the Second Affiliated Hospital of Anhui medical university between January 2015 and December 2018 was conducted. The CURB-65 score was calculated, and other biomarkers including blood lymphocyte countat and serum PCT (a propeptide of calcitonin) level were collected at enrolment. Logistic regression analysis was performed to develop combined models to predict 30-day mortality in overall hospitalized and/or the ICU admission of CAP patients. Then, receiver operating characteristics curve (ROC) analysis was conducted to measure and compare the prognostic values of the CURB-65 score and biomarkers in the combined models.Results The ROC curve analysis using logistic regression of the new combined models showed that the CURB-65 score combined with lymphocyte count and serum PCT level (designated as CURB-65L P) improved the predictive value and was sensitive diagnostic model in predicting the 30-day mortality of CAP patients.Conclusion Serum level of lymphocytes or PCT alone is a strong prognostic factor for evaluation of 30-day mortality of CAP patients. Incorporation of both factors improves the sensitivity of the CURB-65 scoring system in the prediction of the 30-day mortality. This new CURB-65LP scoring system is simple, but more accurate for evaluating the severity of CAP with higher sensitivity and specificity than the current CURB-65 scoring system.

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