scholarly journals Anxiety, depression and post-traumatic stress disorder in refugees resettling in high-income countries: systematic review and meta-analysis

BJPsych Open ◽  
2020 ◽  
Vol 6 (4) ◽  
Author(s):  
Jens-R. Henkelmann ◽  
Sanne de Best ◽  
Carla Deckers ◽  
Katarina Jensen ◽  
Mona Shahab ◽  
...  

Background The number of refugees is at its highest since the Second World War and on the rise. Many refugees suffer from anxiety, depression and post-traumatic stress disorder (PTSD), but exact and up-to-date prevalence estimates are not available. Aims To report the pooled prevalence of anxiety and mood disorders and PTSD in general refugee populations residing in high-income countries and to detect sources of heterogeneity therein. Method Systematic review with meta-analyses and meta-regression. Results Systematic searches (final search date 3 August 2019) yielded 66 eligible publications that reported 150 prevalence estimates (total sample N = 14 882). Prevalence rates were 13 and 42% (95% CI 8–52%) for diagnosed and self-reported anxiety, 30 and 40% (95% CI 23–48%) for diagnosed and self-reported depression, and 29 and 37% (95% CI 22–45%) for diagnosed and self-reported PTSD. These estimates are substantially higher relative to those reported in non-refugee populations over the globe and to populations living in conflict or war settings, both for child/adolescent and adult refugees. Estimates were similar over different home and resettlement areas and independent of length of residence. Conclusions Our data indicate a challenging and persisting disease burden in refugees due to anxiety, mood disorders and PTSD. Knowing this is relevant for the development of public health policies of host countries. Scalable interventions, tailored for refugees, should become more readily available.

2016 ◽  
Vol Ano 6 ◽  
pp. 38-42
Author(s):  
Andrea Feijó Mello ◽  
Euthymia B. Almeida Prado

O presente artigo discorre sobre a comorbidade entre transtorno bipolar (TB) e transtorno de estresse póstraumático (TEPT) e questiona sobre certos casos serem melhor avaliados à luz das novas teorias do Research Domain Criteria (RDoC), principalmente aqueles quadros de TEPT com sintomas disfóricos que podem ser classificados como TB, apesar de não preencherem critérios para tal. Nesse caso, questiona-se a comorbidade e propõe-se um aprofundamento da fisiopatologia dessa sintomatologia que está sobreposta. Clinicamente, esse olhar poderá facilitar o manejo farmacológico de pacientes graves com histórico de trauma.


2015 ◽  
Vol 206 (2) ◽  
pp. 93-100 ◽  
Author(s):  
Mathew Hoskins ◽  
Jennifer Pearce ◽  
Andrew Bethell ◽  
Liliya Dankova ◽  
Corrado Barbui ◽  
...  

BackgroundPharmacological treatment is widely used for post-traumatic stress disorder (PTSD) despite questions over its efficacy.AimsTo determine the efficacy of all types of pharmacotherapy, as monotherapy, in reducing symptoms of PTSD, and to assess acceptability.MethodA systematic review and meta-analysis of randomised controlled trials was undertaken; 51 studies were included.ResultsSelective serotonin reuptake inhibitors were found to be statistically superior to placebo in reduction of PTSD symptoms but the effect size was small (standardised mean difference −0.23, 95% CI −0.33 to −0.12). For individual pharmacological agents compared with placebo in two or more trials, we found small statistically significant evidence of efficacy for fluoxetine, paroxetine and venlafaxine.ConclusionsSome drugs have a small positive impact on PTSD symptoms and are acceptable. Fluoxetine, paroxetine and venlafaxine may be considered as potential treatments for the disorder. For most drugs there is inadequate evidence regarding efficacy for PTSD, pointing to the need for more research in this area.


Author(s):  
Juan Manuel Millan-Alanis ◽  
Farid Carranza-Navarro ◽  
Humberto de León-Gutiérrez ◽  
Paloma C. Leyva-Camacho ◽  
Andrea Fernanda Guerrero-Medrano ◽  
...  

2018 ◽  
Vol 2 ◽  
pp. 247054701877906 ◽  
Author(s):  
Juliana Martins Scalabrin ◽  
Marcelo F. Mello ◽  
Walter Swardfager ◽  
Hugo Cogo-Moreira

Objective To evaluate the factorial validity and internal consistency of a measurement model underlying risk of bias as endorsed by Cochrane for use in systematic reviews; more specifically, how the risk of bias tool behaves in the context of studies on psychological therapies used for treatment of post-traumatic stress disorder in adults. Methods We applied confirmatory factor analysis to a systematic review containing 70 clinical trials entitled “Psychological Therapies for Chronic Post-Traumatic Stress Disorder in Adults” under a Bayesian estimator. Seven observed categorical risk of bias items (answered categorically as low, unclear, or high risk of bias) were collected from the systematic review. Results A unidimensional model for the Cochrane risk of bias tool items returned poor fit indices and low factor loadings, indicating questionable validity and internal consistency. Conclusion Although the present evidence is restricted to psychological interventions for post-traumatic stress disorder, it demonstrates that the way risk of bias has been measured in this context may not be adequate. More broadly, the results suggest the importance of testing the risk of bias tool, and the possibility of rethinking the methods used to assess risk of bias in systematic reviews and meta-analyses.


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