Zetidoline, A New Antipsychotic

1984 ◽  
Vol 145 (3) ◽  
pp. 294-299 ◽  
Author(s):  
T. Silverstone ◽  
S. Levine ◽  
H. L. Freeman ◽  
A. Dubini
Keyword(s):  
Side Effects ◽  
Dopamine Receptor ◽  
Blind Study ◽  
Double Blind Study ◽  
Extrapyramidal Side Effects ◽  
Double Blind ◽  
Receptor Blocking ◽  
Selective Dopamine

SummaryZetidoline (ZTD), a compound chemically unrelated to any available antipsychotic, with selective dopamine receptor-blocking properties, was compared with haloperidol (HLP) in a double-blind study on 56 in-patients who had either first episodes or acute relapses of schizophrenia. ZTD was found to be safe, as effective as HLP, and to produce significantly fewer extrapyramidal side-effects (EPS).

scholarly journals A prospective randomised double blind study of the comparison of two opioids- fentanyl and buprenorphine – as adjuvant to spinal bupivacaine in caesarean sections

2017 ◽  
Vol 4 (1) ◽  
pp. 45
Author(s):  
Kamal Sonya ◽  
Davies C. V.
Keyword(s):  
Side Effects ◽  
Intrathecal Morphine ◽  
Maximum Level ◽  
Sensory Block ◽  
Local Anaesthetics ◽  
Blind Study ◽  
Maximum Height ◽  
Double Blind Study ◽  
Double Blind ◽  
Fentanyl Group

<p class="abstract"><strong>Background:</strong> Opioids are first introduced as additives to spinal anaesthesia in 1979, with intrathecal morphine as forerunner. Neuraxial opioids when added to local anaesthetics prolong the duration of sensory block, improve quality of block and no unwanted sympathetic blockade leading to hypotension. This prospective randomized double blind study was undertaken to evaluate the duration of analgesia, sensory and motor blocking properties and side effects of two opioids – Fentanyl and Buprenorphine, when used as adjuvant to spinal Bupivacaine in caesarean section.</p><p class="abstract"><strong>Methods:</strong> Sixty patients between the age group 18-35 years belonging to ASA I and II posted for elective LSCS were randomly divided into two groups. Each group consisting of 30 patients , received either 1.8 ml 0.5% Bupivacaine with 25 mcg Fentanyl (group F) or 1.8 ml 0.5% Bupivacaine with 75 mcg buprenorphine (Group B). The onset, maximum level and duration of sensory and motor blockade and hemodynamic parameters were monitored.</p><p class="abstract"><strong>Results:</strong> Maximum height of sensory block was achieved faster in fentanyl group (i.e. 4.09±1.12 minutes compared to 4.56±1.21 minutes in buprenorphine group). Duration of analgesia was significantly prolonged in buprenorphine group. It was 317±54 minutes and 214±35 minutes respectively for buprenorphine and fentanyl groups.</p><p class="abstract"><strong>Conclusions:</strong> The study thus concluded that although fentanyl produce faster sensory block, duration of analgesia is longer with buprenorphine, and both the drugs do not cause significant side effects.</p>

A Double-Blind Out-Patient Trial of Indalpine vs Mianserin

1985 ◽  
Vol 147 (3) ◽  
pp. 306-309 ◽  
Author(s):  
G. J. Naylor ◽  
B. Martin
Keyword(s):  
Side Effects ◽  
Treated Group ◽  
Blind Study ◽  
Antidepressant Effect ◽  
Double Blind Study ◽  
Double Blind ◽  
Significant Difference

SummaryIndalpine 150 mg per day and mianserin 60 mg per day were compared in a double-blind study of 65 depressed out-patients: 52 patients completed the 4-week trial. At the end of four weeks there was no significant difference in antidepressant effect between the two drugs; but in the first two weeks, improvement in the mianserin-treated group was significantly greater than that in the indalpine group. The mianserin-treated group reported more side-effects of sedation (eg. drowsiness, clumsiness, heaviness of limbs etc.) and one patient on indalpine developed a mild leucopenia.

Comparative Efficacy of Lormetazepam (Noctamid®) and Diazepam (Valium®) in 100 Out-Patients with Insomnia

1981 ◽  
Vol 9 (3) ◽  
pp. 199-202 ◽  
Author(s):  
M Sastre y Hernández ◽  
H-D Hentschel ◽  
K Fichte
Keyword(s):  
Side Effects ◽  
Sleep Disorders ◽  
Blind Study ◽  
Double Blind Study ◽  
Comparative Efficacy ◽  
Double Blind ◽  
Better Than

Lormetazepam (Noctamid®) at a dosage of 1 mg was compared with diazepam (Valium®) at a dosage of 5 mg in a 7-day double-blind study. The study involved fifty patients in the lormetazepam group and fifty patients in the diazepam group. All the patients were suffering from sleep disorders as a concomitant symptom of general diseases. Lormetazepam was significantly better than diazepam in the: Reduction of the time taken to fall asleep (p < 0.05) Prolongation of the duration of uninterrupted sleep (p < 0.05) Reduction of the frequency of awakening (p < 0.05) Lormetazepam displayed no hang-over effects or other side-effects and, in this respect too, was significantly superior to diazepam (p < 0.05).

A Double Blind Study of the Effect of Tranexamic Acid in Essential Menorrhagia

1968 ◽  
Vol 20 (03/04) ◽  
pp. 583-587 ◽  
Author(s):  
J Vermylen ◽  
M. L Verhaegen-Declercq ◽  
M Verstraete ◽  
F Fierens
Keyword(s):  
Side Effects ◽  
Oral Administration ◽  
Tranexamic Acid ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind

SummaryOral administration of tranexamic acid, in a dosage of 3 g daily from the first day of menstruation onwards, significantly decreases menstrual haemoglobin loss in women with so-called essential menorrhagia.The frequency of side-effects reported did not differ between “active” and “placebo” periods.

Prevention of Rheumatic Fever

1973 ◽  
Vol 12 (8) ◽  
pp. 501-503 ◽  
Author(s):  
Ham Jackson
Keyword(s):  
Side Effects ◽  
Antibiotic Therapy ◽  
Rheumatic Fever ◽  
Streptococcal Pharyngitis ◽  
Blind Study ◽  
Effective Drug ◽  
Double Blind Study ◽  
Double Blind ◽  
Negative Results ◽  
Group A

Poststreptococcal sequelae can be markedly reduced by antibiotic therapy which eradicates the organism from the pharynx. In a double blind study, the effectiveness of clindamycin palmitate liquid was compared with that of ampicillin for eradicating group A beta hemolytic streptococci from patients with pharyngitis. Cultures four days posttherapy were negative in 95 (93.2%) of 102 clindamycin treated patients and in 92 (87.6%) of 105 in the ampicillin group. Seventy-six clindamycin treated and 79 ampicillin treated patients had 28-day cultures with negative results in 69 (90.8%) and 67 (84.8%), respectively. Possible side effects were both mild and infrequent, 3.8 per cent from ampicillin and 2.6 per cent from clindamycin. It was concluded that clindamycin palmitate is palatable, relatively free of side effects and is an effective drug for treatment of streptococcal pharyngitis. No poststreptococcal sequelae occurred.

A Controlled Trial of Taractan in Chronic Schizophrenia

1963 ◽  
Vol 109 (460) ◽  
pp. 418-421 ◽  
Author(s):  
Eileen P. Scanlan ◽  
Arthur E. May
Keyword(s):  
Side Effects ◽  
Controlled Trial ◽  
Chronic Schizophrenia ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind

The purpose of this trial was to evaluate the drug Taractan in the treatment of chronic schizophrenia.Taractan (chlorprothixene) is chemically α-2-chloro-9-(w-dimethylamino propylidene)-thioxanthene. It is claimed to have neuroleptic and tranquillizing properties as well as thymoleptic activity. It is also claimed to be relatively free from side-effects. This property facilitated its use in a double-blind study.

Double-Blind Study of Dothiepin versus Placebo in the Treatment of Primary Fibromyalgia Syndrome

1987 ◽  
Vol 15 (3) ◽  
pp. 154-159 ◽  
Author(s):  
I. Caruso ◽  
P. C. Sarzi Puttini ◽  
L. Boccassini ◽  
S. Santandrea ◽  
M. Locati ◽  
...  
Keyword(s):  
Side Effects ◽  
Fibromyalgia Syndrome ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Clinical Variables ◽  
Primary Fibromyalgia ◽  
Significant Difference ◽  
Primary Fibromyalgia Syndrome

A double-blind study comparing the efficacy and tolerability of dothiepin with that of placebo in the treatment of primary fibromyalgia syndrome was carried out. Dothiepin was shown to improve significantly the condition of patients with primary fibromyalgia syndrome and there was a significant difference between dothiepin and placebo in all the clinical variables measured. Only mild and transient side-effects were reported. Further controlled studies are required to define the effects of dothiepin on fibromyalgia.

A RANDOMIZED, DOUBLE-BLIND STUDY OF PALONOSETRON COMPARED WITH ONDANSETRON IN PREVENTING POSTOPERATIVE NAUSEA AND VOMITING AFTER MODIFIED RADICAL MASTECTOMY SURGERY.

2021 ◽  
pp. 72-74
Author(s):  
Anusha K ◽  
Sherin bright
Keyword(s):  
Side Effects ◽  
Postoperative Nausea ◽  
Radical Mastectomy ◽  
Postoperative Nausea And Vomiting ◽  
Complete Response ◽  
Nausea And Vomiting ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Post Operative Nausea

BACKGROUND : Palonosetron is a new potent 5-hydroxytryptamine 3 antagonist. Although used for chemo induced emesis, data is lacking for PONV. The high incidence of nausea and vomiting after breast surgery is well documented. This study compared the effects of i.v.ondansetron and palonosetron administered at the time of induction for preventing postoperative nausea and vomiting (PONV) in these high-risk patients . The aim was to compare Onda METHODS : nsetron 8 mg and Palonosetron 0.075mg administered intravenously for prevention of post operative nausea and vomiting in patients undergoing modied radical mastectomy 24 hours postoperatively, by a randomised , controlled, double blind study. 70 female non smoking patients scheduled for elective modied radical mastectomy were, allocated randomly into 2 groups . Patients received either Palonosetron 0.075mg (GROUP P ) or ondansetron 8mg ( GROUP O ) intravenously, immediately before induction of general anaesthesia. The occurence of nausea, vomiting, retching, need for rescue antiemetics and side effects were monitored for a period of 24 hours after surgery. The compete response rate and overall PONV for 0 - 24 hours were calculated. The demographic prole of the patients were comparable. The RESULTS : incidence of a complete response (no PONV, no rescue antiemetics ) during 0 - 24 hours in post operative period was signicantly high in GROUP P ( 85.7% vs 62.9%, p=0.02) than GROUP O. The incidence of nausea was signicantly low in GROUP P ( 14.3% vs 37.1%). There was no statistically signicant difference between the 2 groups in vomiting, retching, side effects and need for rescue antiemetics. Thus overall PONV was low in GROUP P (14.3% vs 37.1% p = 0.02 statistically signicant.) We conclude that Palonosetron 0.075mg was more effective for preventing PONV in patients undergoing modied radical mastectomy surgery

scholarly journals Learning to experience side effects after antidepressant intake – Results from a randomized, controlled, double-blind study

2016 ◽  
Vol 234 (3) ◽  
pp. 329-338 ◽  
Author(s):  
Julia Rheker ◽  
Alexander Winkler ◽  
Bettina K. Doering ◽  
Winfried Rief
Keyword(s):  
Side Effects ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Randomized Controlled
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