The Aetiology of Post-traumatic Stress Disorders Following a Natural Disaster

1988 ◽  
Vol 152 (1) ◽  
pp. 116-121 ◽  
Author(s):  
Alexander Cowell McFarlane
Keyword(s):  
Traumatic Stress ◽  
Longitudinal Research ◽  
Past History ◽  
Stress Disorders ◽  
Perceived Threat ◽  
Post Traumatic Stress ◽  
Longitudinal Research Design ◽  
History Of ◽  
Traumatic Stress Disorders ◽  
Post Traumatic

The onset of post-traumatic stress disorders in a group of firefighters who had an intense exposure to a bushfire disaster was investigated using a longitudinal research design. Contrary to expectation, the intensity of exposure, the perceived threat, and the losses sustained in the disaster, when considered independently, were not predictors of post traumatic stress disorder. By contrast, introversion, neuroticism, and a past history and family history of psychiatric disorder were premorbid factors significantly associated with the development of chronic post-traumatic stress disorders.

scholarly journals Writing as a Therapeutic Agent for Collective Healing in the Poems of Tensin Tsundue

2017 ◽  
Vol 1 (2) ◽  
pp. 123
Author(s):  
S. Godwin Raj ◽  
V Rajasekaran
Keyword(s):  
Traumatic Stress ◽  
Therapeutic Agent ◽  
Stress Disorders ◽  
Human Being ◽  
Post Traumatic Stress ◽  
History Of ◽  
Traumatic Stress Disorders ◽  
Post Traumatic ◽  
Almost All ◽  
The Impact

<p><em>Almost all people experience trauma in their life. Surviving in the era that has witnessed a lot of trauma, a millennium composed of two world wars and cold wars, has made every human being experience chains of trauma. Traumatic problems affect a person mentally and physically. There is a long history of human associating himself through a way or therapy to find himself out of the Post Traumatic Stress Disorders (PTSD). This paper projects the importance of writing that serves as a therapy, with the backdrop of the Tibetan writer Tensin Tsundue. Tibet at present undergoes the tough situations due to the Chinese invasion and Tibetans are mostly away from their homeland and staying as refugees in other countries. Tensin Tsundue is a Tibetan activist and writer, and his works bring out the reality of the Tibetan struggle, where his poems stand as a placard for the readers to identify the lost identity of Tibetans. This paper brings out the importance of writing as a therapy to overcome the traumatic stress, and it analyses how an individual writing brings the impact of collective healing into action.</em></p>

scholarly journals PAI-1 protein is a key molecular effector in the transition from normal to PTSD-like fear memory

2021 ◽  
Author(s):  
C. Bouarab ◽  
V. Roullot-Lacarrière ◽  
M. Vallée ◽  
A. Le Roux ◽  
C. Guette ◽  
...  
Keyword(s):  
Traumatic Stress ◽  
Predictive Biomarker ◽  
Stress Disorders ◽  
Glucocorticoid Hormones ◽  
Post Traumatic Stress ◽  
Traumatic Stress Disorders ◽  
Post Traumatic ◽  
Very High ◽  
Moderate Stress ◽  
Pai 1

AbstractModerate stress increases memory and facilitates adaptation. In contrast, intense stress can induce pathological memories as observed in post-traumatic stress disorders (PTSD). A shift in the balance between the expression of tPA and PAI-1 proteins is responsible for this transition. In conditions of moderate stress, glucocorticoid hormones increase the expression of the tPA protein in the hippocampal brain region which by triggering the Erk1/2MAPK signaling cascade strengthens memory. When stress is particularly intense, very high levels of glucocorticoid hormones then increase the production of PAI-1 protein, which by blocking the activity of tPA induces PTSD-like memories. PAI-1 levels after trauma could be a predictive biomarker of the subsequent appearance of PTSD and pharmacological inhibition of PAI-1 activity a new therapeutic approach to this debilitating condition.

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