Brain Imaging and Treatment Response in Spasmodic Torticollis

A patient with spasms of the neck, occurring when he turned his head to the left, responded to treatment with benzhexol. Cerebral blood flow imaging demonstrated reduced uptake in the right corpus striatum compared with the left. The study demonstrates the presence of an abnormality in the basal ganglia; it also illustrates response to drug treatment. Cerebral blood flow imaging may be useful in the detection of basal ganglia abnormalities in spasmodic torticollis and assist in the selection of cases which should be targeted for treatment with drugs.

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Cerebral Blood Flow Imaging with Laser Speckle Contrast Imaging

Neurovascular Coupling Methods - Neuromethods ◽

10.1007/978-1-4939-0724-3_15 ◽

2014 ◽

pp. 287-305

Author(s):

S. M. Shams Kazmi ◽

Lisa M. Richards ◽

Andrew K. Dunn

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Laser Speckle ◽

Flow Imaging ◽

Contrast Imaging ◽

Laser Speckle Contrast Imaging ◽

Blood Flow Imaging ◽

Speckle Contrast

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A-67 Measuring Regional Cerebral Blood Flow with Single-Photon Emission Computed Tomography (SPECT) in Obsessive–Compulsive Disorder

Archives of Clinical Neuropsychology ◽

10.1093/arclin/acab062.85 ◽

2021 ◽

Vol 36 (6) ◽

pp. 1109-1109

Author(s):

Sophia G Perez ◽

Bailey McDonald ◽

Samantha Spagna ◽

Charles J Golden ◽

Kristen Willeumier ◽

...

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Basal Ganglia ◽

Limbic System ◽

Regional Cerebral Blood Flow ◽

Healthy Controls ◽

Regional Cerebral Blood ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

The Right

Abstract Objective To identify regional cerebral blood flow (rCBF) differences between individuals with Obsessive–Compulsive Disorder (OCD) and healthy controls. Mehtods: Healthy controls (n = 81, Mage = 41.9, 53.0% female, 42.0% Caucasian) and persons diagnosed by psychiatric examination with OCD (n = 1020, Mage = 34.8, 33.6% female, 66.3% Caucasian) were selected from a deidentified adult clinical outpatient database. Those with comorbid diagnoses were included. Significant differences (alpha = 0.001) were found for age [t(1099) = −4.4], gender [χ2(2) = 25.7], and race [χ2(12) = 30.1] between groups and therefore were controlled for. Significant rCBF differences were noted in the cerebellum [left:F(1,1096) = 21.6; right:F(1,1096) = 18.3], limbic system [left:F(1,1096) = 12.2; right:F(1,1096) = 10.4], and basal ganglia [left:F(1,1096) = 18.6; right:F(1,1096) = 18.3]. Results Group means comparisons indicated higher perfusion in the cerebellum for the OCD group. Lower perfusion was found in the limbic system and basal ganglia in the OCD group. This study found higher perfusion in the cerebellum among the OCD group. Previous research found increased rCBF in the left cerebellum in OCD before pharmacotherapy. In the right cerebellum, increased rCBF was found among participants with early-onset OCD. Conclusion Overall, there is limited research on the cerebellum because of its use as a reference point. No research was found regarding the limbic system in OCD using SPECT; however, other neuroimaging found increased amygdala reactivity to emotional face stimuli. This study found lower perfusion in the basal ganglia among the OCD group. Previous research found hypoperfusion in the right; however, hypoperfusion in the left was not significant. Updated OCD and rCBF research with SPECT are needed. Limitations included the inclusion of comorbidities and use of DSM-IV-TR rather than DSM-5 diagnosis criteria.

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