Regional Cerebral Blood Flow in Patients with Affective Disorders

Regional cerebral blood flow at rest was measured in 38 patients with major depressive disorders and 16 controls by SPECT with inhalation of xenon-133. All subjects had been withdrawn from medication. The mean hemispheric cerebral blood flow was not statistically different between the controls and the different subgroups of depressed patients defined either by biological markers or clinical characteristics. However, the predominantly cortical blood flow, measured on the outer cerebral rim of the third tomographic slice, was significantly lower on the left hemisphere in bipolar patients when compared with normals and unipolar patients. The same lateralisation was observed in patients with an endogenous depression according to the Newcastle scale.

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Regional Cerebral Blood Flow and Lateralized Hemispheric Dysfunction in Depression

The British Journal of Psychiatry ◽

10.1192/bjp.143.2.128 ◽

1983 ◽

Vol 143 (2) ◽

pp. 128-132 ◽

Cited By ~ 72

Author(s):

P. Uytdenhoef ◽

P. Portelange ◽

J. Jacquy ◽

G. Charles ◽

P. Linkowski ◽

...

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Major Depression ◽

Regional Cerebral Blood Flow ◽

Cerebral Metabolism ◽

Normal Subjects ◽

Regional Cerebral Blood ◽

Cerebral Dysfunction ◽

Bipolar Patients

SummaryCerebral blood flow is known as an indicator of cerebral metabolism. Using the 133Xenon inhalation method, we studied the regional cerebral blood flow (r-CBF) in patients with different subtypes of depression and in remission. A left frontal hypervascularization and a right posterior hypovascularization were found in major depressives, compared to normal subjects, minor depressives, and normothymic bipolar patients. These results tend to confirm the existence of cerebral dysfunction in both hemispheres in major depression, as reported by other authors using different techniques.

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Aging and Recognition Memory: Changes in Regional Cerebral Blood Flow Associated with Components of Reaction Time Distributions

Journal of Cognitive Neuroscience ◽

10.1162/089892999563571 ◽

1999 ◽

Vol 11 (5) ◽

pp. 511-520 ◽

Cited By ~ 50

Author(s):

David J. Madden ◽

Lawrence R. Gottlob ◽

Laura L. Denny ◽

Timothy G. Turkington ◽

James M. Provenzale ◽

...

Keyword(s):

Older Adults ◽

Blood Flow ◽

Young Adults ◽

Cerebral Blood Flow ◽

Reaction Time ◽

Task Performance ◽

Regional Cerebral Blood Flow ◽

Regional Cerebral Blood ◽

Age Related ◽

The Mean

We used H215O positron emission tomography (PET) to measure age-related changes in regional cerebral blood flow (rCBF) during a verbal recognition memory task. Twelve young adults (20 to 29 years) and 12 older adults (62 to 79 years) participated. Separate PET scans were conducted during Encoding, Baseline, and Retrieval conditions. Each of the conditions involved viewing a series of 64 words and making a two-choice response manually. The complete reaction time (RT) distributions in each task condition were characterized in terms of an ex-Gaussian model (convolution of exponential and Gaussian functions). Parameter estimates were obtained for the mean of the exponential component (τ), representing a task-specific decision process and the mean of the Gaussian component (μ), representing residual sensory coding and response processes. Independently of age group, both μ and τ were higher in the Encoding and Retrieval conditions than in the Baseline condition, and τ was higher during Retrieval than during Encoding. Age-related slowing in task performance was evident primarily in μ. For young adults, rCBF activation in the right prefrontal cortex, in the Retrieval condition, was correlated positively with μ but not with τ. For older adults, rCBF changes (both increases and decreases) in several cortical regions were correlated with both μ and τ. The data suggest that the attentional demands of this task are relatively greater for older adults and consequently lead to the recruitment of additional neural systems during task performance.

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Increase in regional cerebral blood flow following experimental arterial air embolism

Journal of Neurosurgery ◽

10.3171/jns.1971.34.5.0665 ◽

1971 ◽

Vol 34 (5) ◽

pp. 665-671 ◽

Cited By ~ 12

Author(s):

Norval M. Simms ◽

George S. Kush ◽

Don M. Long ◽

Merle K. Loken ◽

Lyle A. French

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Regional Cerebral Blood Flow ◽

Air Embolism ◽

Regional Cerebral Blood ◽

Pathogenetic Mechanism ◽

Content Type ◽

Flow Response ◽

The Mean ◽

The Right

✓ Acute intracranial hemodynamic alterations consequent to arterial air embolism were studied in the dog using the radioxenon clearance technique. In eight dogs, the mean pre-embolic (control) hemispheric flow was 28.3 ml/100 gm/min. Following the injection of varying amounts of air into the right vertebral artery, there was an augmentation in the measured cerebral blood flow in all animals. Statistical analysis revealed the flow response to be independent of the amounts of air used in these experiments. The mean post-embolic cerebral blood flow was 39.3 ml/100 gm/min, representing a statistically significant increase of 11.0 ml/100 gm/min. Although the post-embolic supernormal flow may be due to the interaction of multiple pathophysiologic factors, air-induced traumatic vasodilatation is advocated as the most important pathogenetic mechanism. Prolonged vasodilatation with loss of autoregulation results in physiological shunting of blood through the affected capillary beds. Alterations in the intracerebral vasculature due to arterial air embolism are compared with studies by other investigators who have observed the effects in extracerebral vessels.

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Effect of noradrenalin on regional cerebral blood flow depending on initial state of the mean arterial pressure

Bulletin of Experimental Biology and Medicine ◽

10.1007/bf00788085 ◽

1970 ◽

Vol 69 (6) ◽

pp. 608-610

Author(s):

É. S. Gabrielyan ◽

A. M. Harper

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Mean Arterial Pressure ◽

Arterial Pressure ◽

Regional Cerebral Blood Flow ◽

Regional Cerebral Blood ◽

Initial State ◽

The Mean

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Regional Cerebral Blood Flow (rCBF) in Migraine During the Interictal Period: Different rCBF Patterns in Patients With and Without Aura

Cephalalgia ◽

10.1046/j.1468-2982.1996.1603161.x ◽

1996 ◽

Vol 16 (3) ◽

pp. 161-168 ◽

Cited By ~ 15

Author(s):

E Facco ◽

M Munari ◽

F Baratto ◽

AU Behr ◽

A Dal Palu ◽

...

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Regional Cerebral Blood Flow ◽

Migraine Without Aura ◽

Tension Type Headache ◽

Regional Cerebral Blood ◽

Healthy Control ◽

The Mean ◽

Type Headache ◽

Age Range

The aim of this study was to evaluate the rCBF (133Xe clearance method) in migrainous patients free from attack. Fifty patients suffering from migraine without aura (group M) and 20 suffering from migraine with aura (group MA) (age range 20-50 years) were submitted to 32 channel rCBF mapping during the interictal period. The rCBF data of patients were compared with those obtained from 60 healthy control subjects (group C) and 21 patients suffering from tension-type headache (group TH). The mean (average of all channels) rCBF values were: group M=70.5 ± 13.7ml/100g/min; group MA=56.6 ± 11.4ml/100g/min; group C=62.3 ± 8.3ml/100g/min; group TH=62.1 ± 8.4ml/100g/min (F=11.93; p<0.001). As expected, patients belonging to group TH had a normal rCBF. The mean rCBF of group M was significantly higher than that of groups C and TH, while in group MA it was significantly lower than in groups C and TH. Group M showed a diffuse hyperemia, while group MA showed rCBF values significantly lower than normal in posterior regions, according to aura. Our results suggest that: (a) the rCBF pattern in migrainous patients is different from that in both controls and TH patients, even during the interictal period; (b) patients suffering from migraine with and without aura are two distinct subpopulations with opposite rCBF deviations.

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Changes in regional cerebral blood flow demonstrated by 99mTc-HMPAO SPECT in euthymic bipolar patients

European Archives of Psychiatry and Clinical Neuroscience ◽

10.1007/s00406-007-0766-7 ◽

2007 ◽

Vol 258 (3) ◽

pp. 144-151 ◽

Cited By ~ 17

Author(s):

Atesci Figen Culha ◽

Ozdel Osman ◽

Yuksel Dogangün ◽

Karadag Filiz ◽

Kırac Suna ◽

...

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Regional Cerebral Blood Flow ◽

Regional Cerebral Blood ◽

Hmpao Spect ◽

Bipolar Patients ◽

99Mtc Hmpao

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Estimation of regional cerebral blood flow using N-isopropyl-p-123I iodoamphetamine acquisition data from the lungs and brain

Nuklearmedizin ◽

10.3413/nukmed-0640-14-01 ◽

2014 ◽

Vol 53 (06) ◽

pp. 221-226

Author(s):

S. Abe ◽

Y. Takahashi ◽

N. Fujita ◽

M. Ikeda ◽

N. Ota ◽

...

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Regional Cerebral Blood Flow ◽

Photon Emission ◽

Previous Method ◽

Emission Computed Tomography ◽

Regional Cerebral Blood ◽

Arterial Blood ◽

The Mean ◽

Method R

Summary Aim: Previously, we devised a method for estimating 123I labeled N-isopropyl-p-iodo- amphetamine (123I IMP) arterial blood activity at 10 minutes after intravenous injection of 123I IMP (Ca10) without any blood sampling using 123I IMP autoradiography (ARG) acquisition data, and verified its usefulness for quantification of regional cerebral blood flow (rCBF). In this study, we attempted to develop an improved noninvasive method for estimating rCBF. Patients, methods: 123I IMP studies with 23 patients and 15O-H2O positron emission tomography (PET) ARG studies with 20 patients were evaluated. Multiple regression analysis was used to estimate an integral of the arterial blood counts during the time after injection of 123I (JCa) using parameters from the time series of the lung counts and brain counts as the explanatory variables and the fraction [brain single-photon emission computed tomography (SPECT) average count / the mean of rCBFs (mean CBF) measured by 15O-H2O PET ARG method] as the objective variable. Results: The regression equation was as follows: Estimated JCa = (7.09x10-3 · Cb12) - (1.57x10-4 · CbpreSPECT) + (9.48x10-5 · CbpostSPECT) + (1.35x10-4· L15) - (6.95x10-4· L33) + (7.61x10-4· L81) - (0.417), where Cb12: brain count at 12 minutes, Cbpre-SPECT: brain count before SPECT, Cbpost-SPECT: brain count after SPECT, L15, L33, and L81: lung count at 15, 33, and 81 seconds, respectively. The mean CBF values (ml/min/100g) calculated using the estimated JCa values more closely correlated with those measured by 15O-H2O PET ARG method (r = 0.833, p < 0.01) than those obtained by our previous method (r = 0.590, p < 0.01). Conclusion: The rCBFs obtained by this method approximated more accurately to the values measured by 15O-H2O PET ARG method than those obtained by our previous method.

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