Increase in regional cerebral blood flow following experimental arterial air embolism

1971 ◽  
Vol 34 (5) ◽  
pp. 665-671 ◽  
Author(s):  
Norval M. Simms ◽  
George S. Kush ◽  
Don M. Long ◽  
Merle K. Loken ◽  
Lyle A. French
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Air Embolism ◽  
Regional Cerebral Blood ◽  
Pathogenetic Mechanism ◽  
Content Type ◽  
Flow Response ◽  
The Mean ◽  
The Right

✓ Acute intracranial hemodynamic alterations consequent to arterial air embolism were studied in the dog using the radioxenon clearance technique. In eight dogs, the mean pre-embolic (control) hemispheric flow was 28.3 ml/100 gm/min. Following the injection of varying amounts of air into the right vertebral artery, there was an augmentation in the measured cerebral blood flow in all animals. Statistical analysis revealed the flow response to be independent of the amounts of air used in these experiments. The mean post-embolic cerebral blood flow was 39.3 ml/100 gm/min, representing a statistically significant increase of 11.0 ml/100 gm/min. Although the post-embolic supernormal flow may be due to the interaction of multiple pathophysiologic factors, air-induced traumatic vasodilatation is advocated as the most important pathogenetic mechanism. Prolonged vasodilatation with loss of autoregulation results in physiological shunting of blood through the affected capillary beds. Alterations in the intracerebral vasculature due to arterial air embolism are compared with studies by other investigators who have observed the effects in extracerebral vessels.

Regional cerebral blood flow patterns of change following the own body image exposure in eating disorders: A longitudinal study

2009 ◽  
Vol 24 (5) ◽  
pp. 275-281 ◽  
Author(s):  
Teresa Rodriguez-Cano ◽  
Luis Beato-Fernandez ◽  
Inmaculada Garcia-Vilches ◽  
Ana Garcia-Vicente ◽  
Victor Poblete-Garcia ◽  
...  
Keyword(s):  
Body Image ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Body Dissatisfaction ◽  
Regional Cerebral Blood Flow ◽  
Whole Body ◽  
Regional Cerebral Blood ◽  
Temporal Area ◽  
The Right

AbstractObjectiveThe aim of the present study is to see if the changes in the regional cerebral blood flow (rCBF) experienced by restrictive anorexia nervosa (AR) and bulimia nervosa (BN) patients, following the exposure to their own body image, persist at follow-up.MethodsThree single photon emission computed tomography (SPECT) were performed on nine patients with a DSM-IV diagnosis of AR, 13 with BP, and 12 controls: at rest, following a neutral stimulus, and after exposure to their previously filmed whole body image. Body dissatisfaction was measured by means of the Body Dissatisfaction Questionnaire (BSQ). One year later the same assessment was repeated.ResultsFollowing the exposure to their own body image, BN showed an increase in body dissatisfaction, which was associated with the increase in the rCBF of the Right Temporal Area. Those changes persisted at follow-up.DiscussionMore specific long term therapies are needed for the treatment of the averse response showed by ED patients to their own body image exposure that is associated with the hyperactivation of the right temporal area when they are confronted with their whole body image.

scholarly journals Regional Cerebral Blood Flow during Rest and Skilled Hand Movements by Xenon-133 Inhalation and Emission Computerized Tomography

1981 ◽  
Vol 1 (4) ◽  
pp. 385-389 ◽  
Author(s):  
Martin Lauritzen ◽  
Leif Henriksen ◽  
Niels A. Lassen
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Single Photon ◽  
Photon Emission ◽  
Hand Movements ◽  
Regional Cerebral Blood ◽  
Symmetric Pattern ◽  
Xenon 133 ◽  
The Right

Regional cerebral blood flow (CBF) was studied in 16 normal adult volunteers during rest and in 10 the study was repeated during skilled hand movements. A fast-rotating (“dynamic”), single-photon emission computerized tomograph (ECT) with four detector heads was used. Xenon-133 was inhaled over a 1-min period at a concentration of 10 mCi/L. The arrival and washout of the radioisotope was recorded during four 1-min periods. Two slices, 2 cm thick, 7 and 12 cm above the orbitomeatal line were obtained in every study. CBF averaged 60 ml/100 g/min (SD ± 11) in the lower slice and 51 ml/100 g/min (SD ± 13) in the upper slice. A symmetric pattern comparing right to left sides was found in both slices. Finger tapping and writing with the right hand increased CBF in specific areas of the upper slice: in the contralateral hand area by 35 ± 15% ( p < 0.025), and in the supplementary motor area on both sides by 34 ± 15% ( p < 0.025).

A-67 Measuring Regional Cerebral Blood Flow with Single-Photon Emission Computed Tomography (SPECT) in Obsessive–Compulsive Disorder

2021 ◽  
Vol 36 (6) ◽  
pp. 1109-1109
Author(s):  
Sophia G Perez ◽  
Bailey McDonald ◽  
Samantha Spagna ◽  
Charles J Golden ◽  
Kristen Willeumier ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Basal Ganglia ◽  
Limbic System ◽  
Regional Cerebral Blood Flow ◽  
Healthy Controls ◽  
Regional Cerebral Blood ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
The Right

Abstract Objective To identify regional cerebral blood flow (rCBF) differences between individuals with Obsessive–Compulsive Disorder (OCD) and healthy controls. Mehtods: Healthy controls (n = 81, Mage = 41.9, 53.0% female, 42.0% Caucasian) and persons diagnosed by psychiatric examination with OCD (n = 1020, Mage = 34.8, 33.6% female, 66.3% Caucasian) were selected from a deidentified adult clinical outpatient database. Those with comorbid diagnoses were included. Significant differences (alpha = 0.001) were found for age [t(1099) = −4.4], gender [χ2(2) = 25.7], and race [χ2(12) = 30.1] between groups and therefore were controlled for. Significant rCBF differences were noted in the cerebellum [left:F(1,1096) = 21.6; right:F(1,1096) = 18.3], limbic system [left:F(1,1096) = 12.2; right:F(1,1096) = 10.4], and basal ganglia [left:F(1,1096) = 18.6; right:F(1,1096) = 18.3]. Results Group means comparisons indicated higher perfusion in the cerebellum for the OCD group. Lower perfusion was found in the limbic system and basal ganglia in the OCD group. This study found higher perfusion in the cerebellum among the OCD group. Previous research found increased rCBF in the left cerebellum in OCD before pharmacotherapy. In the right cerebellum, increased rCBF was found among participants with early-onset OCD. Conclusion Overall, there is limited research on the cerebellum because of its use as a reference point. No research was found regarding the limbic system in OCD using SPECT; however, other neuroimaging found increased amygdala reactivity to emotional face stimuli. This study found lower perfusion in the basal ganglia among the OCD group. Previous research found hypoperfusion in the right; however, hypoperfusion in the left was not significant. Updated OCD and rCBF research with SPECT are needed. Limitations included the inclusion of comorbidities and use of DSM-IV-TR rather than DSM-5 diagnosis criteria.

Diminished regional cerebral blood flow response to vibration in patients with blepharospasm

Neurology ◽  
1999 ◽  
Vol 52 (2) ◽  
pp. 291-291 ◽  
Author(s):  
R. J. Feiwell ◽  
K. J. Black ◽  
L. A. McGee-Minnich ◽  
A. Z. Snyder ◽  
A.-M. MacLeod ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Blood Flow Response ◽  
Flow Response

Compartmental abnormalities of regional cerebral blood flow in children with head trauma

1972 ◽  
Vol 36 (4) ◽  
pp. 463-470 ◽  
Author(s):  
Samuel S. Kasoff ◽  
Lawrence H. Zingesser ◽  
Kenneth Shulman
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Gray Matter ◽  
Regional Cerebral Blood Flow ◽  
Head Injuries ◽  
Relative Weight ◽  
Compartmental Analysis ◽  
Regional Cerebral Blood ◽  
Content Type ◽  
Pediatric Age Group

✓ Regional cerebral blood flow (CBFr) and compartmental analysis in a series of children with closed head injuries have demonstrated abnormalities of both rate and distribution of blood flow. The most frequent derangement was a triphasic flow pattern overlying one or more regions of traumatized brain. The rate of flow in this third compartment is two to five times the rate of normal gray matter flow; while the relative weight of the compartment varies between 3.5% and 15%. The pathophysiology of this third, rapid compartment of flow is discussed, and the argument put forth that such flow does not represent hyperperfusion but rather an ischemia of the gray matter because such blood flow is not available to the tissue for nutrition. If this is so, it may well be a cause of permanent sequelae in the pediatric age group.

Regional cerebral blood flow and metabolism in reversible ischemia due to vasospasm

1985 ◽  
Vol 62 (4) ◽  
pp. 539-546 ◽  
Author(s):  
William J. Powers ◽  
Robert L. Grubb ◽  
Roy P. Baker ◽  
Mark A. Mintun ◽  
Marcus E. Raichle
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Emission Tomography ◽  
Neurological Deficits ◽  
Regional Cerebral Blood ◽  
Content Type ◽  
Cerebral Metabolic Rate ◽  
Positron Emission ◽  
Reversible Ischemia

✓ Regional cerebral blood flow (rCBF) and regional cerebral metabolic rate of oxygen (rCMRO2) were measured by positron emission tomography (PET) in four patients with subarachnoid hemorrhage and hemiparesis due to cerebral vasospasm. With resolution of the vasospasm, two patients recovered and two remained hemiparetic. Contralateral to the hemiparesis, rCBF was slightly higher in the two patients who eventually recovered (15.0 and 16.2 ml/100 gm/min) than in the two who remained hemiparetic (12.0 and 11.7 ml/100 gm/min). The rCMRO2 measurements showed similar differences, with values of 1.34 and 2.60 ml/100 gm/min in the patients who recovered, and 0.72 and 1.66 ml/100 gm/min in those who did not. These preliminary findings indicate that with PET studies it may be possible to prospectively differentiate patients with neurological deficits due to reversible ischemia from patients with irreversible infarction.

scholarly journals Effects of tDCS Dose and Electrode Montage on regional cerebral blood flow and motor behavior

2021 ◽  
Author(s):  
Anant Shinde ◽  
Karl Lerud ◽  
Fanny Munsch ◽  
David C Alsop ◽  
Gottfried Schlaug
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Brain Regions ◽  
Regional Cerebral Blood ◽  
Left Hand ◽  
Motor Region ◽  
Left And Right ◽  
The Right ◽  
Sequence Performance

AbstractWe used three dose levels (Sham, 2mA and 4mA) and two different electrode montages (unihemispheric or bihemispheric) to examine DOSE and MONTAGE effects on regional cerebral blood flow (rCBF) as a surrogate marker of neural activity, and on a finger sequence task, as a surrogate behavioral measure drawing on brain regions targeted by transcranial direct current stimulation (tDCS). We placed the anodal electrode over the right motor region (C4) while the cathodal or return electrode was placed either over a left supraorbital region (unihemispheric montage) or over the left motor region (C3 in the bihemispheric montage). Performance changes in the finger sequence task for both hands (left hand: p = 0.0026, and right hand: p = 0.0002) showed a linear tDCS dose response, but no effect of montage. rCBF in the the right hemispheric perirolandic area increased with dose under the anodal electrode (p = 0.027), while in the perirolandic ROI in the left hemisphere, rCBF showed a trend to increase with dose (p = 0.053), and significant effect of montage (p = 0.00004). The bihemispheric montage showed additional rCBF increases in frontomesial regions in the 4mA condition but not in the 2mA condition. Furthermore, we found correlations between rCBF changes in the right perirolandic region and improvements in the finger sequence task performance (FSP) for left and right hand. Our data support not only a strong direct tDCS dose effect for rCBF and FSP as surrogate measures of targeted brain regions, but also indirect effects on rCBF in functionally connected regions (e.g., frontomesial regions), particularly in the higher dose condition, and on FSP of the ipsilateral hand (to the anodal electrode). At higher dose and irrespective of polarity, a wider network of sensorimotor regions is positively affected by tDCS.Graphical AbstractHighlightstDCS-DOSE had linear effect on finger sequence performance for both handsrCBF changes in both perirolandic ROIs demonstrated tDCS-DOSE effects and left perirolandic ROI demonstrated tDCS-MONTAGE effects.Simulated current intensity in the left and right perirolandic ROI strongly correlated with the contralateral hand’s finger sequence performance.tDCS-Tolerability scores did not correlate with change in rCBF or finger sequence performance of the left hand.

Effect of naloxone on regional cerebral blood flow during endotoxin shock in conscious rats

1987 ◽  
Vol 253 (3) ◽  
pp. R425-R433
Author(s):  
W. R. Law ◽  
J. L. Ferguson
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Endotoxin Shock ◽  
Sprague Dawley ◽  
Regional Cerebral Blood ◽  
Large Share ◽  
Flow Measurements ◽  
Sprague Dawley Rats ◽  
The Right

Maintenance of cerebral blood flow (CBF) is vital during cardiovascular shock. Since opioids have been implicated in the pathophysiology of endotoxin shock and have been shown to alter cerebral perfusion patterns, we determined whether opioids were responsible for any of the changes in regional CBF observed during endotoxin shock and whether the use of naloxone might impair or aid in the maintenance of CBF. When blood flow (BF) is studied with microspheres in rats, the left ventricle of the heart is often cannulated via the right carotid artery. Questions have arisen concerning the potential adverse effects of this method on CBF in the hemisphere ipsilateral to the ligated artery. We measured right and left regional CBF by use of this route of cannulation. Twenty-four hours after cannulations were performed, flow measurements were made using radiolabeled microspheres in conscious unrestrained male Sprague-Dawley rats (300-400 g) before and 10, 30 and 60 min after challenging with 10 mg/kg Escherichia coli endotoxin (etx) or saline. Naloxone (2 mg/kg) or saline was given as a treatment 25 min post-etx. We found no significant differences between right and left cortical, midbrain, or cerebellar BF at any time in any treatment group. After etx, the whole brain received a large share of the depressed cardiac output. Thus global CBF was not significantly reduced below its pre-etx value, an effect unaltered by naloxone. Regionally, BF was reduced to cerebellum and midbrain by 30 min post-etx. Naloxone prevented this depression. No region was affected to a greater or lesser degree than others.(ABSTRACT TRUNCATED AT 250 WORDS)

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