Regional Cerebral Blood Flow and Lateralized Hemispheric Dysfunction in Depression

1983 ◽  
Vol 143 (2) ◽  
pp. 128-132 ◽  
Author(s):  
P. Uytdenhoef ◽  
P. Portelange ◽  
J. Jacquy ◽  
G. Charles ◽  
P. Linkowski ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Major Depression ◽  
Regional Cerebral Blood Flow ◽  
Cerebral Metabolism ◽  
Normal Subjects ◽  
Regional Cerebral Blood ◽  
Cerebral Dysfunction ◽  
Bipolar Patients

SummaryCerebral blood flow is known as an indicator of cerebral metabolism. Using the 133Xenon inhalation method, we studied the regional cerebral blood flow (r-CBF) in patients with different subtypes of depression and in remission. A left frontal hypervascularization and a right posterior hypovascularization were found in major depressives, compared to normal subjects, minor depressives, and normothymic bipolar patients. These results tend to confirm the existence of cerebral dysfunction in both hemispheres in major depression, as reported by other authors using different techniques.

scholarly journals Comparison of the Effects of Intravenous Papaverine Hydrochloride and Oral Pavabid HP Capsulets on Regional Cerebral Blood Flow in Normal Individuals

1983 ◽  
Vol 3 (4) ◽  
pp. 442-447 ◽  
Author(s):  
Lawrence C. McHenry ◽  
David A. Stump ◽  
George Howard ◽  
Thomas T. Novack ◽  
Don H. Bivins ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Normal Subjects ◽  
Normal Male ◽  
Regional Cerebral Blood ◽  
Normal Individuals ◽  
Left And Right ◽  
Male Subjects ◽  
Papaverine Hydrochloride

A single-blind study was conducted in 13 right-handed normal male subjects to compare the effects of oral and i.v. papaverine on regional cerebral blood flow (rCBF). Six xenon-133 inhalation rCBF measurements were performed on each subject; three tests—baseline, placebo, and drug evaluations—were carried out on each of two separate days. The oral and i.v. drugs were randomized for first-day administration. rCBF, measured as flow gray (FG), increased significantly (p ≤ 0.001) from baseline with both drug forms. Increases of 10.53% and 13.94% (left and right hemispheres, respectively) were demonstrated 90 min after a single 600-mg dose of oral papaverine. Increases of 5.09% and 8.69%, respectively, were recorded immediately after a single 100-mg dose of i. v. papaverine. FG also increased significantly (p ≤ 0.001) for both drug forms when compared to that of placebo. Placebo produced only a slight increase (not significant) with both the oral and i.v. groups. The data show that both oral and i.v. papaverine are equally effective in increasing rCBF in normal subjects.

Regional cerebral blood flow asymmetries in a group of 189 normal subjects at rest

1991 ◽  
Vol 4 (1) ◽  
pp. 57-63 ◽  
Author(s):  
Guido Rodriguez ◽  
Richard Coppola ◽  
Fabrizio De Carli ◽  
Stefano Francione ◽  
Stefano Marenco ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Normal Subjects ◽  
Regional Cerebral Blood

The relationship of regional cerebral blood flow with subtypes of major depression

2004 ◽  
Vol 28 (3) ◽  
pp. 537-546 ◽  
Author(s):  
Kostas N. Fountoulakis ◽  
Apostolos Iacovides ◽  
George Gerasimou ◽  
Fotis Fotiou ◽  
Christina Ioannidou ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Major Depression ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Relationship Of ◽  
The Relationship

Regional Cerebral Blood Flow in Patients with Affective Disorders

1990 ◽  
Vol 157 (3) ◽  
pp. 359-365 ◽  
Author(s):  
V. Delvenne ◽  
F. Delecluse ◽  
Ph. P. Hubain ◽  
A. Schoutens ◽  
V. De Maertelaer ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Depressive Disorders ◽  
Endogenous Depression ◽  
Regional Cerebral Blood ◽  
Major Depressive Disorders ◽  
The Mean ◽  
Bipolar Patients ◽  
Tomographic Slice

Regional cerebral blood flow at rest was measured in 38 patients with major depressive disorders and 16 controls by SPECT with inhalation of xenon-133. All subjects had been withdrawn from medication. The mean hemispheric cerebral blood flow was not statistically different between the controls and the different subgroups of depressed patients defined either by biological markers or clinical characteristics. However, the predominantly cortical blood flow, measured on the outer cerebral rim of the third tomographic slice, was significantly lower on the left hemisphere in bipolar patients when compared with normals and unipolar patients. The same lateralisation was observed in patients with an endogenous depression according to the Newcastle scale.

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