scholarly journals Future therapeutic targets in mood disorders: the glucocorticoid receptor

2000 ◽  
Vol 177 (5) ◽  
pp. 390-395 ◽  
Author(s):  
Richard McQuade ◽  
Allan H. Young
Keyword(s):  
Glucocorticoid Receptor ◽  
Mood Disorders ◽  
Hpa Axis ◽  
Negative Feedback ◽  
Clinical Studies ◽  
Glucocorticoid Receptors ◽  
Therapeutic Targets ◽  
Feedback Mechanism ◽  
Hypothalamic Pituitary Adrenal ◽  
Negative Feedback Mechanism

BackgroundThe hypercortisolaemia and dysfunction of the hypothalamic–pituitary–adrenal (HPA) axis associated with mood disorders have been attributed to a breakdown in the glucocorticoid-receptor-mediated negative feedback mechanism regulating HPA activity. Reinstating normal feedback may be therapeutic in mood disorders.AimsTo review the evidence for the involvement of the glucocorticoid receptor in the pathogenesis and treatment of mood disorders.MethodMedline and hand searches were carried out, selecting literature relevant to psychiatrists and psychopharmacologists.ResultsA dysfunction in glucocorticoid receptors is integral to the HPA abnormalities of mood disorders. Antidepressant and mood-stabilising drugs can up-regulate glucocorticoid receptors, restoring glucocorticoid function. Preliminary clinical studies targeting the glucocorticoid receptor are encouraging.ConclusionsDrugs designed specifically to up-regulate glucocorticoid receptors may be integral to future strategies in treating mood disorders.

scholarly journals 60 YEARS OF NEUROENDOCRINOLOGY: Glucocorticoid dynamics: insights from mathematical, experimental and clinical studies

2015 ◽  
Vol 226 (2) ◽  
pp. T55-T66 ◽  
Author(s):  
Francesca Spiga ◽  
Jamie J Walker ◽  
Rita Gupta ◽  
John R Terry ◽  
Stafford L Lightman
Keyword(s):  
Hpa Axis ◽  
Negative Feedback ◽  
Clinical Studies ◽  
Dynamic Processes ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis

A pulsatile pattern of secretion is a characteristic of many hormonal systems, including the glucocorticoid-producing hypothalamic–pituitary–adrenal (HPA) axis. Despite recent evidence supporting its importance for behavioral, neuroendocrine and transcriptional effects of glucocorticoids, there has been a paucity of information regarding the origin of glucocorticoid pulsatility. In this review we discuss the mechanisms regulating pulsatile dynamics of the HPA axis, and how these dynamics become disrupted in disease. Our recent mathematical, experimental and clinical studies show that glucocorticoid pulsatility can be generated and maintained by dynamic processes at the level of the pituitary–adrenal axis, and that an intra-adrenal negative feedback may contribute to these dynamics.

scholarly journals Hypothalamic glucocorticoid receptor in CRF neurons is essential for HPA axis habituation to repeated stressor

2020 ◽  
Author(s):  
Carine Dournes ◽  
Julien Dine ◽  
Juan-Pablo Lopez ◽  
Elena Brivio ◽  
Elmira Anderzhanova ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Hpa Axis ◽  
Paraventricular Nucleus ◽  
Glucocorticoid Receptors ◽  
Psychological Disorders ◽  
Well Being ◽  
Hypothalamic Pituitary Adrenal ◽  
Crf Neurons ◽  
Inhibitory Tone ◽  
Pituitary Adrenal Axis

Short abstractHabituation of the hypothalamic-pituitary-adrenal (HPA) axis to repeated homotypic stressors is crucial for the organism’s well-being. Many physiological and psychological disorders are associated with HPA axis dysfunction. Here, we show that glucocorticoid receptors in CRF neurons of the hypothalamic paraventricular nucleus are essential for HPA habituation. By increasing inhibitory tone onto CRF neurons, glucocorticoid receptors led to essential cellular modulation and hypothalamic-pituitary-adrenal axis activation dampening, when re-exposed to the same stressor.

scholarly journals Dream Recall/Affect and the Hypothalamic–Pituitary–Adrenal Axis

2021 ◽  
Vol 3 (3) ◽  
pp. 403-408
Author(s):  
Athanasios Tselebis ◽  
Emmanouil Zoumakis ◽  
Ioannis Ilias
Keyword(s):  
Hpa Axis ◽  
Glucocorticoid Receptors ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Free Form ◽  
Dream Recall ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Concise Review ◽  
Pathological Conditions ◽  
Pituitary Adrenal Axis

In this concise review, we present an overview of research on dream recall/affect and of the hypothalamic–pituitary–adrenal (HPA) axis, discussing caveats regarding the action of hormones of the HPA axis (mainly cortisol and its free form, cortisol-binding globulin and glucocorticoid receptors). We present results of studies regarding dream recall/affect and the HPA axis under physiological (such as waking) or pathological conditions (such as in Cushing’s syndrome or stressful situations). Finally, we try to integrate the effect of the current COVID-19 situation with dream recall/affect vis-à-vis the HPA axis.

Activation of the Na+/K+-ATPase by insulin and glucose as a putative negative feedback mechanism in pancreatic beta-cells

2008 ◽  
Vol 457 (6) ◽  
pp. 1351-1360 ◽  
Author(s):  
M. Düfer ◽  
D. Haspel ◽  
P. Krippeit-Drews ◽  
L. Aguilar-Bryan ◽  
J. Bryan ◽  
...  
Keyword(s):  
Beta Cells ◽  
Negative Feedback ◽  
Pancreatic Beta Cells ◽  
Feedback Mechanism ◽  
Negative Feedback Mechanism

scholarly journals Negative feedback in ants: crowding results in less trail pheromone deposition

2013 ◽  
Vol 10 (81) ◽  
pp. 20121009 ◽  
Author(s):  
Tomer J. Czaczkes ◽  
Christoph Grüter ◽  
Francis L. W. Ratnieks
Keyword(s):  
Negative Feedback ◽  
Trail Pheromone ◽  
Distribution Networks ◽  
Feedback Mechanism ◽  
Lasius Niger ◽  
Feedback Signal ◽  
Control Mechanisms ◽  
Negative Feedback Mechanism ◽  
Self Organized ◽  
Fold Reduction

Crowding in human transport networks reduces efficiency. Efficiency can be increased by appropriate control mechanisms, which are often imposed externally. Ant colonies also have distribution networks to feeding sites outside the nest and can experience crowding. However, ants do not have external controllers or leaders. Here, we report a self-organized negative feedback mechanism, based on local information, which downregulates the production of recruitment signals in crowded parts of a network by Lasius niger ants. We controlled crowding by manipulating trail width and the number of ants on a trail, and observed a 5.6-fold reduction in the number of ants depositing trail pheromone from least to most crowded conditions. We also simulated crowding by placing glass beads covered in nest-mate cuticular hydrocarbons on the trail. After 10 bead encounters over 20 cm, forager ants were 45 per cent less likely to deposit pheromone. The mechanism of negative feedback reported here is unusual in that it acts by downregulating the production of a positive feedback signal, rather than by direct inhibition or the production of an inhibitory signal.

scholarly journals RGS4 is a negative feedback mechanism of Angiotensin II‐mediated aldosterone production in human adrenal cells

2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Damian G Romero ◽  
Maria W Plonczynski ◽  
Licy L Yanes ◽  
Tanganika R Washington ◽  
Gina Covington ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Negative Feedback ◽  
Feedback Mechanism ◽  
Adrenal Cells ◽  
Negative Feedback Mechanism ◽  
Aldosterone Production

Intrinsic and extrinsic mechanisms contribute to maintain the JAK/STAT pathway aberrantly activated in T-type large granular lymphocyte leukemia

Blood ◽  
2013 ◽  
Vol 121 (19) ◽  
pp. 3843-3854 ◽  
Author(s):  
Antonella Teramo ◽  
Cristina Gattazzo ◽  
Francesca Passeri ◽  
Albana Lico ◽  
Giulia Tasca ◽  
...  
Keyword(s):  
Negative Feedback ◽  
Feedback Mechanism ◽  
Large Granular Lymphocyte ◽  
Large Granular Lymphocyte Leukemia ◽  
Negative Feedback Mechanism ◽  
Key Points ◽  
Stat Pathway

Key PointsIn T-LGLL, autologous LGL-depleted PBMCs release high levels of IL-6 contributing to the constitutive STAT3 activation in leukemic LGL. Leukemic LGLs show SOCS3 down-modulation, which is responsible for lack of the negative feedback mechanism controlling STAT3 activation.

scholarly journals Studies on the Physiological Role of Hypothalamic TRH on the Negative Feedback Mechanism of the Pituitary-Thyroid Axis

1979 ◽  
Vol 55 (6) ◽  
pp. 776-786
Author(s):  
Masatomo MORI ◽  
Kihachi OHSHIMA ◽  
Sakae MARUTA ◽  
Hitoshi FUKUDA ◽  
Yohnosuke SHIMOMURA ◽  
...  
Keyword(s):  
Negative Feedback ◽  
Physiological Role ◽  
Feedback Mechanism ◽  
Negative Feedback Mechanism ◽  
Pituitary Thyroid Axis ◽  
Thyroid Axis
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