Self-harm in first-episode psychosis

Aims and MethodSuicide in schizophrenia remains frequent. One of the best predictors of suicide, previous self-harm, is increasing in young people. the aim of this case-note review was to investigate the frequency of a history of self-harm for individuals presenting to psychiatric services with a first episode of psychosis in our local area and study their demographic characteristics.ResultsA history of self-harm was found in 32% of the cohort. the predominant method of self-harm was self-laceration. In univariate analyses, age and gender were significant predictors of self-harming behaviour.Clinical ImplicationsThe rate of self-harm among those with first-episode psychosis is high. Efforts to reduce the rate of completed suicide in psychotic illness need to focus on this risk, which often predates contact with psychiatric services. This emphasises again the need for early detection and intervention in psychotic illness.

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Review: about one in five people with first-episode psychosis have a history of deliberate self-harm

Evidence-Based Mental Health ◽

10.1136/eb-2013-101465 ◽

2013 ◽

Vol 16 (4) ◽

pp. 113-113 ◽

Cited By ~ 1

Keyword(s):

First Episode Psychosis ◽

First Episode ◽

Deliberate Self Harm ◽

Episode Psychosis ◽

History Of ◽

Self Harm

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Patterns and predictors of hospitalisation in first-episode psychosis

The British Journal of Psychiatry ◽

10.1192/bjp.178.6.518 ◽

2001 ◽

Vol 178 (6) ◽

pp. 518-523 ◽

Cited By ~ 47

Author(s):

Attila Sipos ◽

Glynn Harrison ◽

David Gunnell ◽

Shazad Amin ◽

Swaran P. Singh

Keyword(s):

Negative Symptoms ◽

First Episode Psychosis ◽

Psychiatric Services ◽

First Episode ◽

Psychotic Episode ◽

Duration Of Untreated Illness ◽

Specialist Services ◽

Increased Risk ◽

Episode Psychosis

BackgroundLittle is known about predictors of hospitalisation in patients with first-episode psychosis.AimsTo identify the pattern and predictors of hospitalisation of patients with a first psychotic episode making their first contact with specialist services.MethodThree-year follow-up of a cohort of 166 patients with a first episode of psychosis making contact with psychiatric services in Nottingham between June 1992 and May 1994.ResultsEighty-eight (53.0%) patients were admitted within 1 week of presentation; 32 (19.3%) were never admitted during the 3 years of follow-up. Manic symptoms at presentation were associated with an increased risk of rapid admission and an increased overall risk of admission; negative symptoms and a longer duration of untreated illness had an increased risk of late admission.ConclusionsCommunity-oriented psychiatric services might only delay, rather than prevent, admission of patients with predominantly negative symptoms and a longer duration of untreated illness. First-episode studies based upon first admissions are likely to be subject to selection biases, which may limit their representativeness.

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Family history of psychosis negatively impacts age at onset, negative symptoms, and duration of untreated illness and psychosis in first-episode psychosis patients

Psychiatry Research ◽

10.1016/j.psychres.2012.03.001 ◽

2012 ◽

Vol 197 (1-2) ◽

pp. 23-28 ◽

Cited By ~ 20

Author(s):

Michelle Esterberg ◽

Michael Compton

Keyword(s):

Family History ◽

Negative Symptoms ◽

Age At Onset ◽

First Episode Psychosis ◽

First Episode ◽

Duration Of Untreated Illness ◽

Episode Psychosis ◽

History Of

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Neuroactive Steroids in First-Episode Psychosis: A Role for Progesterone?

Schizophrenia Research and Treatment ◽

10.1155/2016/1942828 ◽

2016 ◽

Vol 2016 ◽

pp. 1-6 ◽

Cited By ~ 2

Author(s):

Martino Belvederi Murri ◽

Flaminia Fanelli ◽

Uberto Pagotto ◽

Elena Bonora ◽

Federico Triolo ◽

...

Keyword(s):

Psychotic Disorders ◽

Serum Levels ◽

First Episode Psychosis ◽

Neuroactive Steroids ◽

First Episode ◽

Positive Symptoms ◽

Symptom Dimensions ◽

Episode Psychosis ◽

Male Patients ◽

And Gender

Neuroactive steroids may play a role in the pathophysiology of psychotic disorders, but few studies examined this issue. We compared serum levels of cortisol, testosterone, dehydroepiandrosterone, and progesterone between a representative sample of first-episode psychosis (FEP) patients and age- and gender-matched healthy subjects. Furthermore, we analyzed the associations between neuroactive steroids levels and the severity of psychotic symptom dimensions. Male patients had lower levels of progesterone than controls (p=0.03). Progesterone levels were inversely associated with the severity of positive symptoms (p=0.007). Consistent with preclinical findings, results suggest that progesterone might have a role in the pathophysiology of psychotic disorders.

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