Patterns and predictors of hospitalisation in first-episode psychosis

BackgroundLittle is known about predictors of hospitalisation in patients with first-episode psychosis.AimsTo identify the pattern and predictors of hospitalisation of patients with a first psychotic episode making their first contact with specialist services.MethodThree-year follow-up of a cohort of 166 patients with a first episode of psychosis making contact with psychiatric services in Nottingham between June 1992 and May 1994.ResultsEighty-eight (53.0%) patients were admitted within 1 week of presentation; 32 (19.3%) were never admitted during the 3 years of follow-up. Manic symptoms at presentation were associated with an increased risk of rapid admission and an increased overall risk of admission; negative symptoms and a longer duration of untreated illness had an increased risk of late admission.ConclusionsCommunity-oriented psychiatric services might only delay, rather than prevent, admission of patients with predominantly negative symptoms and a longer duration of untreated illness. First-episode studies based upon first admissions are likely to be subject to selection biases, which may limit their representativeness.

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Exploring the relationship between recency and frequency of cannabis use and diminished expression and apathy as two dimensions of negative symptoms in first episode psychosis. A one-year follow-up study

Schizophrenia Research ◽

10.1016/j.schres.2021.08.004 ◽

2021 ◽

Vol 236 ◽

pp. 89-96

Author(s):

Henrik Myhre Ihler ◽

Trine Vik Lagerberg ◽

Siv Hege Lyngstad ◽

Ingrid Melle ◽

Kristin Lie Romm

Keyword(s):

Negative Symptoms ◽

First Episode Psychosis ◽

Two Dimensions ◽

Cannabis Use ◽

First Episode ◽

Follow Up Study ◽

Episode Psychosis ◽

One Year ◽

The Relationship

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Aggressive incidents in first-episode psychosis

The British Journal of Psychiatry ◽

10.1192/bjp.178.5.433 ◽

2001 ◽

Vol 178 (5) ◽

pp. 433-440 ◽

Cited By ~ 64

Author(s):

John Milton ◽

Shazad Amin ◽

Swaran P. Singh ◽

Glynn Harrison ◽

Peter Jones ◽

...

Keyword(s):

First Episode Psychosis ◽

Psychotic Symptoms ◽

First Episode ◽

Psychotic Episode ◽

Increased Risk ◽

Episode Psychosis ◽

Clinical Associations ◽

Independent Effects ◽

One Act ◽

Service Contact

BackgroundRecent research has reported increased risk of aggressive incidents by individuals with psychotic illness.AimsTo examine acts of aggression in first-episode psychosis.MethodSubjects with a first-episode psychosis were ascertained from a defined catchment area (Nottingham, UK) and reassessed at 3 years (n=166) using clinical interview, informants, health care and forensic records.ResultsOf the subjects, 9.6% demonstrated at least one act of serious aggression (defined as weapon use, sexual assault or victim injury) during at least one psychotic episode and 23.5% demonstrated lesser acts of aggression (defined as all other acts of aggression). For all aggressive subjects (33.1%), unemployment (OR=3.6, 95%CI 1.6–8.0), comorbid substance misuse (OR=3.1, CI 1.1–8.8) and symptoms of overactivity at service contact (OR=6.9, CI 2.7–17.8) had independent effects on risk of aggression.ConclusionsWe confirmed some previously reported demographic and clinical associations with aggression in first-episode psychosis but no relationship with specific psychotic symptoms or diagnostic groups was observed.

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Cognitive functioning in patients with first-episode psychosis stratified by level of negative symptoms: A 1-year follow-up study

Psychiatry Research ◽

10.1016/j.psychres.2019.112554 ◽

2019 ◽

Vol 281 ◽

pp. 112554 ◽

Cited By ~ 1

Author(s):

Magnus Johan Engen ◽

Carmen Simonsen ◽

Ingrid Melle ◽

Ann Færden ◽

Siv Hege Lyngstad ◽

...

Keyword(s):

Cognitive Functioning ◽

Negative Symptoms ◽

First Episode Psychosis ◽

First Episode ◽

Follow Up Study ◽

Episode Psychosis

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Resting-state functional connectivity of the striatum predicts improvement in negative symptoms and general functioning in patients with first-episode psychosis: A 1-year naturalistic follow-up study

IBRO Reports ◽

10.1016/j.ibror.2019.07.1458 ◽

2019 ◽

Vol 6 ◽

pp. S462-S463

Author(s):

Sanghoon Oh ◽

Minah Kim ◽

Tae Young Lee ◽

Taekwan Kim ◽

Jun Soo Kwon

Keyword(s):

Functional Connectivity ◽

Resting State ◽

Negative Symptoms ◽

First Episode Psychosis ◽

First Episode ◽

Resting State Functional Connectivity ◽

Follow Up Study ◽

Episode Psychosis ◽

General Functioning

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Family history of psychosis negatively impacts age at onset, negative symptoms, and duration of untreated illness and psychosis in first-episode psychosis patients

Psychiatry Research ◽

10.1016/j.psychres.2012.03.001 ◽

2012 ◽

Vol 197 (1-2) ◽

pp. 23-28 ◽

Cited By ~ 20

Author(s):

Michelle Esterberg ◽

Michael Compton

Keyword(s):

Family History ◽

Negative Symptoms ◽

Age At Onset ◽

First Episode Psychosis ◽

First Episode ◽

Duration Of Untreated Illness ◽

Episode Psychosis ◽

History Of

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Poster #M166 EVOLUTION OF RISK FACTORS FOR LATE AND PERSISTENT NEGATIVE SYMPTOMS OVER TIME: RESULTS FROM A 12-YEAR FOLLOW-UP OF FIRST EPISODE PSYCHOSIS PATIENTS

Schizophrenia Research ◽

10.1016/s0920-9964(14)70716-9 ◽

2014 ◽

Vol 153 ◽

pp. S250-S251

Author(s):

Hugh Ramsay ◽

John Lyne ◽

Michele Hill ◽

Niall Crumlish ◽

Niall Turner ◽

...

Keyword(s):

Risk Factors ◽

Negative Symptoms ◽

First Episode Psychosis ◽

First Episode ◽

Episode Psychosis ◽

Persistent Negative Symptoms ◽

Over Time

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Negative symptoms in first‐episode psychosis: Clinical correlates and 1‐year follow‐up outcomes in London Early Intervention Services

Early Intervention in Psychiatry ◽

10.1111/eip.12502 ◽

2017 ◽

Vol 13 (3) ◽

pp. 443-452 ◽

Cited By ~ 4

Author(s):

Aikaterini Rammou ◽

Helen L. Fisher ◽

Sonia Johnson ◽

Barnaby Major ◽

Nikola Rahaman ◽

...

Keyword(s):

Early Intervention ◽

Negative Symptoms ◽

First Episode Psychosis ◽

First Episode ◽

Early Intervention Services ◽

Clinical Correlates ◽

Episode Psychosis ◽

Intervention Services

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Antipsychotic treatment resistance in first-episode psychosis: prevalence, subtypes and predictors

Psychological Medicine ◽

10.1017/s0033291717000435 ◽

2017 ◽

Vol 47 (11) ◽

pp. 1981-1989 ◽

Cited By ~ 78

Author(s):

A. Demjaha ◽

J. M. Lappin ◽

D. Stahl ◽

M. X. Patel ◽

J. H. MacCabe ◽

...

Keyword(s):

Negative Symptoms ◽

Age At Onset ◽

Treatment Resistance ◽

First Episode Psychosis ◽

First Episode ◽

Antipsychotic Treatment ◽

Treatment Resistant ◽

Illness Onset ◽

Episode Psychosis

BackgroundWe examined longitudinally the course and predictors of treatment resistance in a large cohort of first-episode psychosis (FEP) patients from initiation of antipsychotic treatment. We hypothesized that antipsychotic treatment resistance is: (a) present at illness onset; and (b) differentially associated with clinical and demographic factors.MethodThe study sample comprised 323 FEP patients who were studied at first contact and at 10-year follow-up. We collated clinical information on severity of symptoms, antipsychotic medication and treatment adherence during the follow-up period to determine the presence, course and predictors of treatment resistance.ResultsFrom the 23% of the patients, who were treatment resistant, 84% were treatment resistant from illness onset. Multivariable regression analysis revealed that diagnosis of schizophrenia, negative symptoms, younger age at onset, and longer duration of untreated psychosis predicted treatment resistance from illness onset.ConclusionsThe striking majority of treatment-resistant patients do not respond to first-line antipsychotic treatment even at time of FEP. Clinicians must be alert to this subgroup of patients and consider clozapine treatment as early as possible during the first presentation of psychosis.

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