scholarly journals Liver X receptor activation promotes macrophage-to-feces reverse cholesterol transport in a dyslipidemic hamster model

2009 ◽  
Vol 51 (4) ◽  
pp. 763-770 ◽  
Author(s):  
François Briand ◽  
Morgan Tréguier ◽  
Agnès André ◽  
Didier Grillot ◽  
Marc Issandou ◽  
...  
Keyword(s):  
Reverse Cholesterol Transport ◽  
Receptor Activation ◽  
Liver X Receptor ◽  
Cholesterol Transport ◽  
Hamster Model

scholarly journals Tissue-Specific Liver X Receptor Activation Promotes Macrophage Reverse Cholesterol Transport In Vivo

2010 ◽  
Vol 30 (4) ◽  
pp. 781-786 ◽  
Author(s):  
Tomoyuki Yasuda ◽  
Didier Grillot ◽  
Jeffery T. Billheimer ◽  
François Briand ◽  
Philippe Delerive ◽  
...  
Keyword(s):  
Reverse Cholesterol Transport ◽  
Receptor Activation ◽  
Liver X Receptor ◽  
Cholesterol Transport ◽  
Tissue Specific

scholarly journals Cholestenoic Acid Is a Naturally Occurring Ligand for Liver X Receptor α**This work was supported by NIH grants.

Endocrinology ◽  
2000 ◽  
Vol 141 (11) ◽  
pp. 4180-4184 ◽  
Author(s):  
Ching Song ◽  
Shutsung Liao
Keyword(s):  
Lipid Metabolism ◽  
Nuclear Receptor ◽  
Reverse Cholesterol Transport ◽  
Liver X Receptor ◽  
Cholesterol Transport ◽  
Nuclear Receptor Coactivator ◽  
Naturally Occurring ◽  
Liver X Receptor Α ◽  
Cholestenoic Acid ◽  
Neutral Sterols

Abstract Excessive cholesterol is eliminated from extrahepatic cells by reverse cholesterol transport, a process by which neutral sterols are transferred to extracellular acceptor lipoproteins for further transport to the liver. Another process independent of lipoproteins involves excretion of 3β-hydroxy-5-cholesten-25(R)-26-carboxylic (cholestenoic) acid, a metabolite of 27-hydroxycholesterol. Physiological concentrations of cholestenoic acid activated the nuclear receptor liver X receptor α (LXRα; NR1H3), but not other oxysterol receptors. As a ligand, cholestenoic acid modulated interaction of LXRα with the nuclear receptor coactivator Grip-1. Cholestenoic acid, therefore, may function as a signaling molecule for regulation of lipid metabolism via LXRα.

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