scholarly journals Thematic review series: Lipid Posttranslational Modifications.Geranylgeranylation of Rab GTPases

2006 ◽  
Vol 47 (3) ◽  
pp. 467-475 ◽  
Author(s):  
Ka Fai Leung ◽  
Rudi Baron ◽  
Miguel C. Seabra
Keyword(s):  
Author(s):  
Naomi Jacobs ◽  
Peter Edwards ◽  
Caitlin D. Cottrill ◽  
Karen Salt

Societies and their underlying infrastructure are in the process of being transformed by digital technology, a change that requires updated legislation and governance structures to respond to new information contexts. One particular area of rapid growth is that of connected devices that are increasingly being deployed in the physical environment as part of the so-called Internet of Things (IoT). There has been significant attention by policymakers at both national and international levels as to the economic and social benefits these technologies can bring and how they can be effectively implemented, leading to a range of different governance models. Many of these models relate to larger scale deployments as part of “smart city” urban infrastructure programs. Unlike private sector Internet of Things devices, which require buy-in from individuals who voluntarily purchase technology and choose to use it, public space deployments can affect entire communities. They must therefore particularly include mechanisms by which citizens can be empowered. We present a thematic review of literature and policy pertaining to IoT governance models, and construct a framework of principles for IoT governance, highlighting emerging and remaining questions. Four emergent themes (Levels of Governance, Legitimacy and Representation, Accountability, and Transparency) are illustrated using case studies at two levels; national and supranational top-down governance models, and city-based context-specific implementation models.


2021 ◽  
pp. 004208592110179
Author(s):  
Audrey Addi-Raccah ◽  
Paola Dusi ◽  
Noa Seeberger Tamir

We present an empirical overview of current research in the area of parental involvement (PI) based on a bibliometric analysis of 544 articles published between 2014 and 2018, and a thematic review of 39 of the Q1-journal articles in the sample, which contributed to a more detailed illustration of the knowledge base of PI research. The findings reveal an ongoing increase in the intensity of research in five distinct foci. The research is shown to be largely urban- and US-centric and dominated by diverse psychological and sociological perspectives. Implications and avenues for future research have been suggested.


2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Shirley Tremel ◽  
Yohei Ohashi ◽  
Dustin R. Morado ◽  
Jessie Bertram ◽  
Olga Perisic ◽  
...  

AbstractThe lipid phosphatidylinositol-3-phosphate (PI3P) is a regulator of two fundamental but distinct cellular processes, endocytosis and autophagy, so its generation needs to be under precise temporal and spatial control. PI3P is generated by two complexes that both contain the lipid kinase VPS34: complex II on endosomes (VPS34/VPS15/Beclin 1/UVRAG), and complex I on autophagosomes (VPS34/VPS15/Beclin 1/ATG14L). The endosomal GTPase Rab5 binds complex II, but the mechanism of VPS34 activation by Rab5 has remained elusive, and no GTPase is known to bind complex I. Here we show that Rab5a–GTP recruits endocytic complex II to membranes and activates it by binding between the VPS34 C2 and VPS15 WD40 domains. Electron cryotomography of complex II on Rab5a-decorated vesicles shows that the VPS34 kinase domain is released from inhibition by VPS15 and hovers over the lipid bilayer, poised for catalysis. We also show that the GTPase Rab1a, which is known to be involved in autophagy, recruits and activates the autophagy-specific complex I, but not complex II. Both Rabs bind to the same VPS34 interface but in a manner unique for each. These findings reveal how VPS34 complexes are activated on membranes by specific Rab GTPases and how they are recruited to unique cellular locations.


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