Stromal Cell-Derived Factor-1 Chemokine Gene Polymorphism Is Not Associated with Onset Age of Japanese Type 1 Diabetes

2003 ◽  
Vol 1005 (1) ◽  
pp. 328-331 ◽  
Author(s):  
TOSHIKATSU SHIGIHARA ◽  
AKIRA SHIMADA ◽  
SATORU YAMADA ◽  
TARO MARUYAMA ◽  
HIROSHI HIROSE ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Gene Polymorphism ◽  
Stromal Cell ◽  
Onset Age ◽  
Chemokine Gene ◽  
Stromal Cell Derived Factor

Stromal-cell derived factor-1 chemokine gene variant is associated with type 1 diabetes age at onset in Japanese population

2003 ◽  
Vol 64 (10) ◽  
pp. 973-978 ◽  
Author(s):  
Akane Ide ◽  
Eiji Kawasaki ◽  
Norio Abiru ◽  
Fuyan Sun ◽  
Tetsuya Fukushima ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Japanese Population ◽  
Stromal Cell ◽  
Age At Onset ◽  
Gene Variant ◽  
Chemokine Gene ◽  
Stromal Cell Derived Factor

scholarly journals A Common Stromal Cell-Derived Factor-1 Chemokine Gene Variant is Associated With the Early Onset of Type 1 Diabetes

Diabetes ◽  
2001 ◽  
Vol 50 (5) ◽  
pp. 1211-1213 ◽  
Author(s):  
D. Dubois-Laforgue ◽  
H. Hendel ◽  
S. Caillat-Zucman ◽  
J.-F. Zagury ◽  
C. Winkler ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Early Onset ◽  
Stromal Cell ◽  
Gene Variant ◽  
Chemokine Gene ◽  
Stromal Cell Derived Factor

scholarly journals HLA class I genes modulate disease risk and age at onset together with DR-DQ in Chinese patients with insulin-requiring type 1 diabetes

Diabetologia ◽  
2021 ◽  
Author(s):  
Ziyu Jiang ◽  
Wenqian Ren ◽  
Hua Liang ◽  
Jinhua Yan ◽  
Daizhi Yang ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Disease Risk ◽  
Hla Class I ◽  
Class I ◽  
Chinese Patients ◽  
Onset Age ◽  
Disease Heterogeneity ◽  
Negatively Associated ◽  
Healthy Control

Abstract Aims/hypothesis The study aimed to investigate the effects of HLA class I genes on susceptibility to type 1 diabetes with different onset ages, in addition to the well-established effects of HLA class II genes. Methods A total of 361 patients with type 1 diabetes (192 patients with onset <18 years and 169 patients with onset ≥18 years) and 500 healthy control participants from China were enrolled and genotyped for the HLA-A, -B, -C, -DQA1, -DQB1 and -DRB1 genes using next-generation sequencing. Results The susceptible DR3 (β = −0.09, p = 0.0009) and DR4-DQ8 (β = −0.13, p = 0.0059) haplotypes were negatively associated with onset age, while the protective DR11 (β = 0.21, p = 0.0314) and DR12 (β = 0.27, p < 0.0001) haplotypes were positively associated with onset age. After adjustment for linkage disequilibrium with DR-DQ haplotypes, A*11:01:01 was positively associated with onset age (β = 0.06, p = 0.0370), while the susceptible C*15:02:01 was negatively associated with onset age (β = −0.21, p = 0.0050). The unit for β was double square-root (fourth root) transformed years of change in onset age associated with per copy of the HLA haplotype/allele. In addition, B*46:01:01 was protective (OR 0.41, 0.46; pc [corrected for multiple comparisons] = 0.0044, 0.0040), whereas A*24:02:01 (OR 2.71, 2.25; pc = 0.0003, 0.0002) and B*54:01:01 (OR 3.96, 3.79; pc = 0.0018, 0.0004) were predisposing in both the <18 group and the ≥18 group compared with healthy control participants. In the context of DR4-DQ4, A*11:01:01 (61.29% vs 28.26%, pc = 0.0144) was increased while the predisposing A*24:02:01 (19.35% vs 47.83%, pc = 0.0403) was decreased in patients with onset ≥18 years when compared with patients with onset <18 years. Conclusions/interpretation In addition to DR-DQ haplotypes, novel HLA class I alleles were detected to play a role in susceptibility to type 1 diabetes with different onset ages, which could improve the understanding of disease heterogeneity and has implications for the design of future studies. Graphical abstract

scholarly journals Body Mass Index and Mortality in Individuals With Type 1 Diabetes

2019 ◽  
Vol 104 (11) ◽  
pp. 5195-5204 ◽  
Author(s):  
Emma H Dahlström ◽  
Niina Sandholm ◽  
Carol M Forsblom ◽  
Lena M Thorn ◽  
Fanny J Jansson ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Excretion Rate ◽  
Albumin Excretion Rate ◽  
Normal Weight ◽  
Onset Age ◽  
Diabetes Onset ◽  
Risk Of Mortality ◽  
The Relationship ◽  
Normal Albumin

Abstract Context The relationship between body mass index (BMI) and mortality may differ between patients with type 1 diabetes and the general population; it is not known which clinical characteristics modify the relationship. Objective Our aim was to assess the relationship between BMI and mortality and the interaction with clinically meaningful factors. Design, Setting, and Participants This prospective study included 5836 individuals with type 1 diabetes from the FinnDiane study. Main Outcome Measure and Methods We retrieved death data for all participants on 31 December 2015. We estimated the effect of BMI on the risk of mortality using a Cox proportional hazards model with BMI as a restricted cubic spline as well as effect modification by adding interaction terms to the spline. Results During a median of 13.7 years, 876 individuals died. The relationship between baseline BMI and all-cause mortality was reverse J-shaped. When analyses were restricted to those with normal albumin excretion rate, the relationship was U-shaped. The nadir BMI (BMI with the lowest mortality) was in the normal weight region (24.3 to 24.8 kg/m2); however, among individuals with diabetic nephropathy, the nadir BMI was in the overweight region (25.9 to 26.1 kg/m2). Diabetic nephropathy, diabetes-onset age, and sex modified the relationship between BMI and mortality (Pinteraction < 0.05). Conclusions Normal weight is optimal for individuals with type 1 diabetes to delay mortality, whereas underweight might be an indication of underlying complications. Maintaining normal weight may translate into reduced risk of mortality in type 1 diabetes, particularly for individuals of male sex, later diabetes-onset age, and normal albumin excretion rate.

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