The Contribution of Orbitofrontal Cortex to Action Selection

2007 ◽  
Vol 1121 (1) ◽  
pp. 174-192 ◽  
Author(s):  
S. B. OSTLUND ◽  
B. W. BALLEINE
Keyword(s):  
Orbitofrontal Cortex ◽  
Action Selection

scholarly journals Parafascicular Thalamic and Orbitofrontal Cortical Inputs to Striatum Represent States for Goal-Directed Action Selection

2021 ◽  
Vol 15 ◽  
Author(s):  
Sandy Stayte ◽  
Amolika Dhungana ◽  
Bryce Vissel ◽  
Laura A. Bradfield
Keyword(s):  
Orbitofrontal Cortex ◽  
Internal State ◽  
Action Selection ◽  
Parafascicular Nucleus ◽  
Cholinergic Interneurons ◽  
Directed Action ◽  
Cortical Inputs ◽  
Partially Observable ◽  
State Context ◽  
Anatomical Evidence

Several lines of evidence accrued over the last 5–10 years have converged to suggest that the parafascicular nucleus of the thalamus and the lateral orbitofrontal cortex each represent or contribute to internal state/context representations that guide action selection in partially observable task situations. In rodents, inactivations of each structure have been found to selectively impair performance in paradigms testing goal-directed action selection, but only when that action selection relies on state representations. Electrophysiological evidence has suggested that each structure achieves this function via inputs onto cholinergic interneurons (CINs) in the dorsomedial striatum. Here, we briefly review these studies, then point to anatomical evidence regarding the afferents of each structure and what they suggest about the specific features that each contribute to internal state representations. Finally, we speculate as to whether this role might be achieved interdependently through direct PF→OFC projections, or through the convergence of independent direct orbitofrontal cortex (OFC) and parafascicular nucleus of the thalamus (PF) inputs onto striatal targets.

scholarly journals Connections of the Mouse Orbitofrontal Cortex and Regulation of Goal-Directed Action Selection by Brain-Derived Neurotrophic Factor

2017 ◽  
Vol 81 (4) ◽  
pp. 366-377 ◽  
Author(s):  
Kelsey S. Zimmermann ◽  
John A. Yamin ◽  
Donald G. Rainnie ◽  
Kerry J. Ressler ◽  
Shannon L. Gourley
Keyword(s):  
Orbitofrontal Cortex ◽  
Neurotrophic Factor ◽  
Action Selection ◽  
Brain Derived Neurotrophic Factor ◽  
Directed Action

scholarly journals Differential encoding of action selection by orbitofrontal and striatal population dynamics

2020 ◽  
Vol 124 (2) ◽  
pp. 634-644
Author(s):  
Long Yang ◽  
Sotiris C. Masmanidis
Keyword(s):  
Population Dynamics ◽  
Orbitofrontal Cortex ◽  
Action Selection ◽  
Choice Task ◽  
Previous Literature ◽  
Neural Signals ◽  
Population Activity ◽  
Differential Encoding ◽  
Alternative Choice ◽  
Dorsomedial Striatum

While previous literature shows that both orbitofrontal cortex (OFC) and dorsomedial striatum (DMS) represent information relevant to selecting specific actions, few studies have directly compared neural signals between these areas. Here we compared OFC and DMS dynamics in mice performing a two-alternative choice task. We found that the animal’s choice could be decoded more accurately from DMS population activity. This work provides among the first evidence that OFC and DMS differentially represent information about an animal’s selected action.

scholarly journals GABAAα1-Mediated Plasticity in the Orbitofrontal Cortex Regulates Context-Dependent Action Selection

2014 ◽  
Vol 40 (4) ◽  
pp. 1027-1036 ◽  
Author(s):  
Andrew M Swanson ◽  
Amanda G Allen ◽  
Lauren P Shapiro ◽  
Shannon L Gourley
Keyword(s):  
Orbitofrontal Cortex ◽  
Action Selection ◽  
Context Dependent

An Integrated Model of Action Selection: Distinct Modes of Cortical Control of Striatal Decision Making

2019 ◽  
Vol 70 (1) ◽  
pp. 53-76 ◽  
Author(s):  
Melissa J. Sharpe ◽  
Thomas Stalnaker ◽  
Nicolas W. Schuck ◽  
Simon Killcross ◽  
Geoffrey Schoenbaum ◽  
...  
Keyword(s):  
State Space ◽  
Orbitofrontal Cortex ◽  
Action Selection ◽  
Medium Spiny Neurons ◽  
Cortical Control ◽  
Complex Environments ◽  
Top Down ◽  
Cholinergic Interneurons ◽  
Spiny Neurons ◽  
Dorsomedial Striatum

Making decisions in environments with few choice options is easy. We select the action that results in the most valued outcome. Making decisions in more complex environments, where the same action can produce different outcomes in different conditions, is much harder. In such circumstances, we propose that accurate action selection relies on top-down control from the prelimbic and orbitofrontal cortices over striatal activity through distinct thalamostriatal circuits. We suggest that the prelimbic cortex exerts direct influence over medium spiny neurons in the dorsomedial striatum to represent the state space relevant to the current environment. Conversely, the orbitofrontal cortex is argued to track a subject's position within that state space, likely through modulation of cholinergic interneurons.

scholarly journals A functional difference in information processing between orbitofrontal cortex and ventral striatum during decision-making behaviour

2014 ◽  
Vol 369 (1655) ◽  
pp. 20130472 ◽  
Author(s):  
Jeffrey J. Stott ◽  
A. David Redish
Keyword(s):  
Decision Making ◽  
Information Processing ◽  
Delay Discounting ◽  
Neural Activity ◽  
Orbitofrontal Cortex ◽  
Ventral Striatum ◽  
Action Selection ◽  
Functional Difference ◽  
Trade Off ◽  
Related Information

Both orbitofrontal cortex (OFC) and ventral striatum (vStr) have been identified as key structures that represent information about value in decision-making tasks. However, the dynamics of how this information is processed are not yet understood. We recorded ensembles of cells from OFC and vStr in rats engaged in the spatial adjusting delay-discounting task , a decision-making task that involves a trade-off between delay to and magnitude of reward. Ventral striatal neural activity signalled information about reward before the rat's decision, whereas such reward-related signals were absent in OFC until after the animal had committed to its decision. These data support models in which vStr is directly involved in action selection, but OFC processes decision-related information afterwards that can be used to compare the predicted and actual consequences of behaviour.

Satiety-responsive neurons in the medial orbitofrontal cortex of the macaque.

2008 ◽  
Vol 122 (1) ◽  
pp. 174-182 ◽  
Author(s):  
Thomas C. Pritchard ◽  
Erin N. Nedderman ◽  
Erin M. Edwards ◽  
Andrew C. Petticoffer ◽  
Gary J. Schwartz ◽  
...  
Keyword(s):  
Orbitofrontal Cortex
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