Changes in Serial Cardiac Troponin T Measurements Are Associated with Adverse Cardiac Events in Patients with Chronic Kidney Disease

2004 ◽  
Vol 11 (5) ◽  
pp. 506-506
Author(s):  
J. H. Han
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Cardiac Troponin T ◽  
Cardiac Events ◽  
Adverse Cardiac Events

scholarly journals FP403ASSOCIATION BETWEEN SERUM OSTEOPROTEGERIN & SERUM HIGH SENSITIVITY CARDIAC TROPONIN T LEVELS WITH CARDIOVASCULAR CALCIFICATION IN CHRONIC KIDNEY DISEASE

2018 ◽  
Vol 33 (suppl_1) ◽  
pp. i170-i171
Author(s):  
Waleed Elrefaey ◽  
Mohamed H Abou Freikha ◽  
Kamal M Okasha ◽  
Medhat M Ashmawy ◽  
Heba A Mourad ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cardiac Troponin ◽  
Troponin T ◽  
High Sensitivity ◽  
Cardiac Troponin T

scholarly journals Biological variation of cardiac troponins in chronic kidney disease

2020 ◽  
Vol 57 (2) ◽  
pp. 162-169
Author(s):  
RA Jones ◽  
J Barratt ◽  
EA Brettell ◽  
P Cockwell ◽  
RN Dalton ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Troponin T ◽  
Biological Variation ◽  
Cardiac Troponin I ◽  
Cardiac Troponin T ◽  
Reference Change Value

Background Patients with chronic kidney disease often have increased plasma cardiac troponin concentration in the absence of myocardial infarction. Incidence of myocardial infarction is high in this population, and diagnosis, particularly of non ST-segment elevation myocardial infarction (NSTEMI), is challenging. Knowledge of biological variation aids understanding of serial cardiac troponin measurements and could improve interpretation in clinical practice. The National Academy of Clinical Biochemistry (NACB) recommended the use of a 20% reference change value in patients with kidney failure. The aim of this study was to calculate the biological variation of cardiac troponin I and cardiac troponin T in patients with moderate chronic kidney disease (glomerular filtration rate [GFR] 30–59 mL/min/1.73 m2). Methods and results Plasma samples were obtained from 20 patients (median GFR 43.0 mL/min/1.73 m2) once a week for four consecutive weeks. Cardiac troponin I (Abbott ARCHITECT® i2000SR, median 4.3 ng/L, upper 99th percentile of reference population 26.2 ng/L) and cardiac troponin T (Roche Cobas® e601, median 11.8 ng/L, upper 99th percentile of reference population 14 ng/L) were measured in duplicate using high-sensitivity assays. After outlier removal and log transformation, 18 patients’ data were subject to ANOVA, and within-subject (CVI), between-subject (CVG) and analytical (CVA) variation calculated. Variation for cardiac troponin I was 15.0%, 105.6%, 8.3%, respectively, and for cardiac troponin T 7.4%, 78.4%, 3.1%, respectively. Reference change values for increasing and decreasing troponin concentrations were +60%/–38% for cardiac troponin I and +25%/–20% for cardiac troponin T. Conclusions The observed reference change value for cardiac troponin T is broadly compatible with the NACB recommendation, but for cardiac troponin I, larger changes are required to define significant change. The incorporation of separate RCVs for cardiac troponin I and cardiac troponin T, and separate RCVs for rising and falling concentrations of cardiac troponin, should be considered when developing guidance for interpretation of sequential cardiac troponin measurements.

Prognostic Significance of Cardiac Troponin-T Level in Chronic Kidney Disease Patients on Hemodialysis

2014 ◽  
Vol 1 (2) ◽  
pp. 60
Author(s):  
MunnaLal Patel ◽  
Rekha Sachan ◽  
Pankaj Singh ◽  
Pushplata Sachan ◽  
ShyamChand Chaudhary ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Prognostic Significance ◽  
Cardiac Troponin T

Clinical significance of cardiac troponin T levels in chronic kidney disease patients: predictive value for cardiovascular risk

2004 ◽  
Vol 43 (5) ◽  
pp. 846-853 ◽  
Author(s):  
Marian Goicoechea ◽  
Soledad Garcıéa de Vinuesa ◽  
Francisco Gómez-Campderá ◽  
Maria José Gutierrez ◽  
Paula Blanco ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Cardiovascular Risk ◽  
Kidney Disease ◽  
Clinical Significance ◽  
Predictive Value ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Cardiac Troponin T
Sign in / Sign up

Export Citation Format

Share Document