The role of misonidazole combined with intraoperative radiation therapy in the treatment of pancreatic carcinoma.

1987 ◽  
Vol 5 (4) ◽  
pp. 579-584 ◽  
Author(s):  
J E Tepper ◽  
W U Shipley ◽  
A L Warshaw ◽  
G L Nardi ◽  
W C Wood ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Locally Advanced ◽  
External Beam Radiation ◽  
Intraoperative Radiation Therapy ◽  
High Dose ◽  
Hypoxic Cell ◽  
External Beam ◽  
Beam Radiation ◽  
External Beam Irradiation ◽  
Intraoperative Radiation

We tested the efficacy of the hypoxic cell sensitizer misonidazole in conjunction with intraoperative electron beam radiation therapy (IORT) and external beam irradiation in patients with locally advanced, nonmetastatic adenocarcinoma of the pancreas. Misonidazole was delivered intravenously (IV) at a dose of 3.5 g/m2 in conjunction with IORT of 1,500 to 2,000 cGy to the pancreas. Additional external beam radiation as administered to 4,960 cGy. The study was based on the premise that the effect of misonidazole would be maximized when a high dose of the drug was administered and, thus, high hypoxic cell sensitization could be obtained when using a high single dose of radiation where the hypoxic fraction would be expected to dominate in the survivors. In a nonrandomized study of 41 patients treated with misonidazole and 22 without, the 1-year local control was 67% and 55%, and 1-year survival was 50% and 77%, respectively. Although there was a bias towards larger tumors in the patients treated with the sensitizer, we were unable to demonstrate an advantage to misonidazole in this clinical situation.

Intraoperative Radiation Therapy

2007 ◽  
Vol 25 (8) ◽  
pp. 971-977 ◽  
Author(s):  
Christopher G. Willett ◽  
Brian G. Czito ◽  
Douglas S. Tyler
Keyword(s):  
Radiation Therapy ◽  
Local Control ◽  
Locally Advanced ◽  
Phase Iii ◽  
External Beam Radiation ◽  
Intraoperative Radiation Therapy ◽  
Partial Breast Irradiation ◽  
High Dose ◽  
Beam Radiation ◽  
Intraoperative Radiation

Intraoperative radiation therapy (IORT) is the delivery of irradiation at the time of an operation. This is performed by different techniques including intraoperative electron beam techniques and high-dose rate brachytherapy. IORT is usually given in combination with external-beam radiation therapy with or without chemotherapy and surgical resection. IORT excludes part or all dose-limiting sensitive structures, thereby increasing the effective dose to the tumor bed (and therefore local control) without significantly increasing normal tissue morbidity. Despite best contemporary therapy, high rates of local failure occur in patients with locally advanced or recurrent rectal cancer, retroperitoneal sarcoma, select gynecologic cancers, and other malignancies. The addition of IORT to conventional treatment methods has improved local control as well as survival in many disease sites in both the primary and locally recurrent disease settings. More recently, there has been interest in the use of IORT as a technique of partial breast irradiation for women with early breast cancer. Given newer and lower cost treatment devices, the use of IORT in clinical practice will likely grow, with increasing integration into the treatment of nonconventional malignancies. Optimally, phase III randomized trials will be carried out to prove its efficacy in these disease sites.

External Beam Radiation Therapy Plus High-Dose-Rate Brachytherapy in the Treatment of Locally Advanced Prostate

Brachytherapy ◽  
2016 ◽  
Vol 15 ◽  
pp. S184
Author(s):  
Ferran Guedea ◽  
Cristina Gutierrez ◽  
Anna Maria Boladeras ◽  
Luigina Santorsa ◽  
Ferrer Ferran ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Dose Rate ◽  
Locally Advanced ◽  
High Dose Rate ◽  
External Beam Radiation Therapy ◽  
External Beam Radiation ◽  
High Dose ◽  
External Beam ◽  
Beam Radiation ◽  
High Dose Rate Brachytherapy

The Role of Intraoperative Radiation Therapy in the Management of Recurrent and Locally Advanced Gynecologic Cancers

2013 ◽  
Vol 23 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Olivia W. Foley ◽  
J. Alejandro Rauh-Hain ◽  
Marcela G. del Carmen
Keyword(s):  
Radiation Therapy ◽  
Locally Advanced ◽  
Target Volume ◽  
External Beam Radiation ◽  
Intraoperative Radiation Therapy ◽  
Tumor Control ◽  
Gynecologic Cancers ◽  
Beam Radiation ◽  
Intraoperative Radiation

For patients with locally advanced primary or recurrent gynecologic cancers, prognosis is poor. Doses of external beam radiation therapy required to treat either gross or microscopic disease in patients previously irradiated or treated surgically exceed doses that are tolerated by normal anatomic structures. Intraoperative radiation therapy allows maximal tumor control achievable with radiation while minimizing radiation exposure of dose-limiting surrounding structures. Intraoperative radiation therapy is a unique treatment modality, allowing direct visualization of the target volume during a planned surgical procedure. Intraoperative radiation therapy has the potential to improve both long-term local control and overall survival especially in patients with para-aortic and/or pelvic sidewall recurrences.

Preoperative Paclitaxel and Concurrent Rapid-Fractionation Radiation for Resectable Pancreatic Adenocarcinoma: Toxicities, Histologic Response Rates, and Event-Free Outcome

2002 ◽  
Vol 20 (10) ◽  
pp. 2537-2544 ◽  
Author(s):  
Peter W. T. Pisters ◽  
Robert A. Wolff ◽  
Nora A. Janjan ◽  
Karen R. Cleary ◽  
Chusilp Charnsangavej ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Pancreatic Adenocarcinoma ◽  
External Beam Radiation Therapy ◽  
External Beam Radiation ◽  
Intraoperative Radiation Therapy ◽  
Preoperative Treatment ◽  
External Beam ◽  
Beam Radiation ◽  
Intraoperative Radiation ◽  
Grade 3

PURPOSE: To evaluate the toxicity of a preoperative regimen of paclitaxel and concurrent external-beam radiation therapy, pancreaticoduodenectomy, and electron-beam intraoperative radiation therapy (EB-IORT) for patients with resectable pancreatic adenocarcinoma. PATIENTS AND METHODS: Patients with localized, potentially resectable pancreatic adenocarcinoma were treated with 30 Gy external-beam radiation therapy and concomitant weekly 3-hour infusions of paclitaxel (60 mg/m2). Radiographic restaging was performed 4 to 6 weeks after chemoradiation, and patients with localized disease underwent pancreatectomy with EB-IORT. RESULTS: Thirty-five patients completed chemoradiation; 16 (46%) experienced grade 3 toxicity. Four patients (11%) required hospitalization for dehydration due to grade 3 nausea and vomiting. Twenty (80%) of 25 patients who underwent surgery underwent pancreatectomy; EB-IORT was used in 13 patients. There were no histologic complete responses to preoperative therapy; 21% of specimens demonstrated more than 50% nonviable cells (grade 2b treatment effect). With a median follow-up period of 46 months, the 3-year overall survival rate with chemoradiation and pancreatectomy was 28%. CONCLUSION: Preoperative paclitaxel-based concurrent chemoradiation is feasible. The toxicity of this regimen seems greater than that with fluorouracil. The histologic responses and survival are similar, suggesting no advantages to paclitaxel-based preoperative treatment.

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