T1-T2N0 Squamous Cell Carcinoma of the Glottic Larynx Treated With Radiation Therapy

2001 ◽  
Vol 19 (20) ◽  
pp. 4029-4036 ◽  
Author(s):  
William M. Mendenhall ◽  
Robert J. Amdur ◽  
Christopher G. Morris ◽  
Russell W. Hinerman
Keyword(s):  
Radiation Therapy ◽  
Local Control ◽  
Treatment Time ◽  
Survival Rates ◽  
Glottic Carcinoma ◽  
Overall Treatment Time ◽  
Poorly Differentiated ◽  
Histologic Differentiation ◽  
Lost To Follow Up

PURPOSE: The end results after radiation therapy for T1-T2N0 glottic carcinoma vary considerably. We analyze patient-related and treatment-related parameters that may influence the likelihood of cure. PATIENTS AND METHODS: Five hundred nineteen patients were treated with radiation therapy and had follow-up for ≥ 2 years. Three patients who were disease-free were lost to follow-up at 7 months, 21 months, and 10.5 years. No other patients were lost to follow-up. RESULTS: Local control rates at 5 years after radiation therapy were as follows: T1A, 94%; T1B, 93%; T2A, 80%; and T2B, 72%. Multivariate analysis of local control revealed that the following parameters significantly influenced this end point: overall treatment time (P < .0001), T stage (P = .0003), and histologic differentiation (P = .013). Patients with poorly differentiated cancers fared less well than those with better differentiated lesions. Rates of local control with laryngeal preservation at 5 years were as follows: T1A and T1B, 95%; T2A, 82%; and T2B, 76%. Cause-specific survival rates at 5 years were as follows: T1A and T1B, 98%; T2A, 95%; and T2B, 90%. One patient with a T1N0 cancer and three patients with T2N0 lesions experienced severe late radiation complications. CONCLUSION: Radiation therapy cures a high percentage of patients with T1-T2N0 glottic carcinomas and has a low rate of severe complications. The major treatment-related parameter that influences the likelihood of cure is overall treatment time.

Radiation therapy for T1,2 glottic carcinoma: impact of overall treatment time on local control

1996 ◽  
Vol 40 (3) ◽  
pp. 225-232 ◽  
Author(s):  
Yasumasa Nishimura ◽  
Yasushi Nagata ◽  
Kaoru Okajima ◽  
Michihide Mitsumori ◽  
Masahiro Hiraoka ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Local Control ◽  
Treatment Time ◽  
Glottic Carcinoma ◽  
Overall Treatment Time

The Effect of Overall Treatment Time of Radiation Therapy on Local Control of T1-Stage Squamous Call Carcinoma of the Glottis

1996 ◽  
Vol 106 (12) ◽  
pp. 1545-1547 ◽  
Author(s):  
Kazushige Hayakawa ◽  
Norio Mitsuhashi ◽  
Tetsuo Akimoto ◽  
Katsuya Maebayashi ◽  
Hitoshi Ishikawa ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Local Control ◽  
Treatment Time ◽  
Overall Treatment Time ◽  
T1 Stage

Dose, fractionation and overall treatment time in radiation therapy — the effects on local control for cancer of the larynx

1994 ◽  
Vol 30 (2) ◽  
pp. 97-108 ◽  
Author(s):  
Wim L.J. van Putten ◽  
Maurice J.C. van der Sangen ◽  
Carel J.M. Hoekstra ◽  
Peter C. Levendag
Keyword(s):  
Radiation Therapy ◽  
Local Control ◽  
Treatment Time ◽  
Dose Fractionation ◽  
Overall Treatment Time

Dose, fractionation and overall treatment time in radiation therapy—The effects on local control for cancer of the larynx

1994 ◽  
Vol 19 (3) ◽  
pp. 188-189
Author(s):  
Wim L.J. van Putten ◽  
Maurice J.C. van der Sangen ◽  
Carel J.M. Hoekstra ◽  
Peter C. Levendag
Keyword(s):  
Radiation Therapy ◽  
Local Control ◽  
Treatment Time ◽  
Dose Fractionation ◽  
Overall Treatment Time

Is Radiation Therapy a Preferred Alternative to Surgery for Squamous Cell Carcinoma of the Base of Tongue?

2000 ◽  
Vol 18 (1) ◽  
pp. 35-35 ◽  
Author(s):  
William M. Mendenhall ◽  
Scott P. Stringer ◽  
Robert J. Amdur ◽  
Russell W. Hinerman ◽  
Giselle J. Moore-Higgs ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Multivariate Analysis ◽  
Radiation Therapy ◽  
Cell Carcinoma ◽  
Local Control ◽  
Treatment Time ◽  
Overall Treatment Time ◽  
Regional Control ◽  
Base Of Tongue ◽  
Local Regional Control

PURPOSE: To evaluate irradiation alone for treatment of base-of-tongue cancer. PATIENTS AND METHODS: Two hundred seventeen patients with squamous cell carcinoma of the base of tongue were treated with radiation alone and had follow-up for ≥ 2 years. RESULTS: Local control rates at 5 years were as follows: T1, 96%; T2, 91%; T3, 81%; and T4, 38%. Multivariate analysis revealed that T stage (P = .0001) and overall treatment time (P = .0006) significantly influenced local control. The 5-year rates of local-regional control were as follows: I, 100%; II, 100%; III, 83%; IVA, 64%; and IVB, 65%. Multivariate analysis revealed that the following parameters significantly affect the probability of this end point: T stage (P = .0001), overall treatment time (P = .0001), overall stage (P = .0131), and addition of a neck dissection (P = .0021). The rates of absolute and cause-specific survival at 5 years were as follows: I, 50% and 100%; II, 81% and 100%; III, 65% and 76%; IVA, 42% and 56%; and IVB, 44% and 52%. Severe radiation complications developed in eight patients (4%). CONCLUSION: The likelihood of cure after external-beam irradiation was related to stage, overall treatment time, and addition of a planned neck dissection. The local-regional control rates and survival rates after radiation therapy were comparable to those after surgery, and the morbidity associated with irradiation was less.

Impact of prolongation of overall treatment time and timing of brachytherapy on outcome of radiation therapy in carcinoma of uterine cervix

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 15032-15032
Author(s):  
V. Goel ◽  
J. K. Singh. ◽  
M. K. Pandey
Keyword(s):  
Completion Time ◽  
Treatment Time ◽  
Residual Disease ◽  
Survival Rates ◽  
Carcinoma Cervix ◽  
Overall Treatment Time ◽  
Regional Control ◽  
Distant Failure ◽  
Bulky Tumor

15032 Background: Studies have described decreased pelvic control & survival rates in invasive ca cervix when overall time in definitive RT is prolonged. We evaluated impact of timing of brachytherapy on outcome. Methods: Retrospective analysis of 338 patients of ca cervix treated with radical RT from Jan 2002 to Dec 2002 at Mahavir Cancer Sansthan Patna. The median age was 50 yrs (23–80 yrs). 73% patients were postmenopausal. Histopathology was Squamous Cell in 97% patients. Most common presenting complaints were bleeding P/V (92%) & discharge P/V (82%); with stage I (3%), II (35%), III (43%), IV (5%), unknown stage in 14% cases. Results: Records of 338 patients (Stage IB to III) treated with definitive irradiation (combination of EBRT & ICRT) were reviewed with reference to loco regional control, distant failure and its correlation with patient and tumor variables including OTT. Out of 302 patients who received complete RT, 24 received 60 Gy in 30 fractions as they were found to be unsuitable or were unwilling for ICRT. The rest received a dose of 50 Gy/25 Fr to 50.4 Gy/28 Fr over a median duration of 37 days. 30 patients received concomitant chemo radiation (cisplatin 40 mg/m2/4 cycles). 276 patients received ICRT (dose 21 Gy in 3 Fractions with a median gap of 43 days (range 5–111) after completion of ERT. The median OTT for completion of ERT & ICRT was 75 days (range 54–177). At an average follow up of 18- 24 months residual disease was seen in 2 cases (0.6%), local recurrence in 14 cases (4%) & distant failure in 14 cases (4%). Post RT complications were seen in 4.7% cases and included small bowel obstruction in 6 cases, VVF in 4 & RVF in 6 cases. Significant correlation was seen between OTT and rate of loco regional recurrences. All local recurrences were seen when OTT was more than 75 days. No significant correlation could be drawn between age, Hemoglobin, tumor histology, & bulky vs. non bulky tumor on loco regional and distant failure. Conclusions: Longer radiotherapy completion time was found to be associated with diminished survival outcomes for patients treated radically for carcinoma cervix. The significance of this observed association requires further investigation & correction to keep OTT as short as possible. No significant financial relationships to disclose.

scholarly journals SURVIVAL OUTCOMES IN EARLY GLOTTIC CARCINOMA; A SINGLE INSTITUTION EXPERIENCE

2016 ◽  
Vol 2 (4) ◽  
Author(s):  
Muhammad Atif Munawar ◽  
Kamran Saeed ◽  
Tabinda Sadaf ◽  
Irfan Haider ◽  
Arif Jamshed
Keyword(s):  
Overall Survival ◽  
Squamous Cell ◽  
Treatment Time ◽  
Early Stage ◽  
Verrucous Carcinoma ◽  
Neck Region ◽  
Research Centre ◽  
Glottic Carcinoma ◽  
Lost To Follow Up

Purpose: Laryngeal cancers are amongst the most common cancers affecting head and neck region. In this study, we analyse the overall survival (OS) following hypofractionated radiotherapy (RT) in early stage glottic carcinoma treated at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore. Methods: Between October 2003 and June 2009, 87 patients with early stage glottic carcinoma were treated with hypofractionated RT. All patients were included in the study. The ratio of male: female is 94%:6%. Mean age was 62 years (range 31–83 years). 66% of the patients were smokers. AJCC stage was T1a in 76%, T1b 20% and T2 in 4% of the patients. Histological distribution was; squamous cell carcinoma 97%, verrucous carcinoma 2% and squamous cell spindle variant 1%. Median follow-up time was 59 months (range 4–122 months). RT dose was 55 Gy in 20 fractions over a period of 4 weeks. Median RT treatment time was 28 days (range 23–35 days). Patients that lost to follow-up were contacted through telephone. Results: The 10-year OS was 83%. Patterns of failure was 7 local and 1 distant while 1 patient had persistent disease. 15 patients were dead at the time of study. Cause of death; 13 patients died due to Ischemic heart disease and 2 due to primary disease. Conclusion: Hypofractionated RT 55 Gy in 20 fractions seems to achieve good OS while offering potential for optimizing resources usage. Key words: Glottic carcinoma, hypofractionated, overall survival, radiotherapy 

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