A randomized phase III study of cisplatin with or without raltitrexed in patients (pts) with malignant pleural mesothelioma (MPM): an intergroup study of the EORTC Lung Cancer Group and NCIC

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 7021-7021 ◽  
Author(s):  
J. P. Van Meerbeeck ◽  
C. Manegold ◽  
R. Gaafar ◽  
R. J. van Klaveren ◽  
E. A. Van Marck ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Malignant Pleural Mesothelioma ◽  
Phase Iii ◽  
Pleural Mesothelioma ◽  
Cancer Group ◽  
Phase Iii Study

Pemetrexed Therapy for Malignant Pleural Mesothelioma

2005 ◽  
Vol 39 (4) ◽  
pp. 678-683 ◽  
Author(s):  
Katarzyna Puto ◽  
Jody S Garey
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Data Extraction ◽  
Relevant Information ◽  
Phase Iii ◽  
Pleural Mesothelioma ◽  
Pivotal Phase ◽  
Pyrimidine Synthesis ◽  
Study Selection ◽  
Phase Iii Study ◽  
American Society

OBJECTIVE: To review pemetrexed, a novel multi-targeted antifolate agent. DATA SOURCES: A literature search was conducted (1985–September 2004) using MEDLINE and CANCERLIT. Recent abstracts from the American Society of Clinical Oncology were also included, along with the manufacturer's information. Key words were pemetrexed, LY-231514, Alimta, multi-targeted antifolate, malignant pleural mesothelioma. STUDY SELECTION AND DATA EXTRACTION: Relevant information on pharmacology, pharmacokinetics, and safety and efficacy of pemetrexed from clinical trials was selected. DATA SYNTHESIS: Pemetrexed inhibits folate metabolism and purine/pyrimidine synthesis. Based on Phase I and II trials, pemetrexed has antitumor activity in solid tumors such as lung, colorectal, and cervical. A pivotal Phase III study in patients with malignant pleural mesothelioma (MPM) demonstrated survival superiority of pemetrexed—cisplatin regimen versus cisplatin. CONCLUSIONS: Pemetrexed is a promising new drug for the treatment of solid malignancies, most notably MPM.

Malignant pleural mesothelioma: Treatment patterns and outcomes from the Spanish Lung Cancer Group

Lung Cancer ◽  
2020 ◽  
Vol 147 ◽  
pp. 83-90 ◽  
Author(s):  
J. Remon ◽  
E. Nadal ◽  
M. Dómine ◽  
J. Ruffinelli ◽  
Y. García ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Malignant Pleural Mesothelioma ◽  
Treatment Patterns ◽  
Pleural Mesothelioma ◽  
Cancer Group
Sign in / Sign up

Export Citation Format

Share Document