Tumor progression in osteosarcoma (OS): Role of the chemokine receptor CXCR4 and of its ligand stromal-cell derived factor 1 (SDF-1)

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 9021-9021 ◽  
Author(s):  
E. Perissinotto ◽  
V. Fonsato ◽  
G. Cavalloni ◽  
F. Leone ◽  
S. Mitola ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Chemokine Receptor ◽  
Stromal Cell ◽  
Chemokine Receptor Cxcr4 ◽  
Stromal Cell Derived Factor

Tumor progression in osteosarcoma (OS): Role of the chemokine receptor CXCR4 and of its ligand stromal-cell derived factor 1 (SDF-1)

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 9021-9021 ◽  
Author(s):  
E. Perissinotto ◽  
V. Fonsato ◽  
G. Cavalloni ◽  
F. Leone ◽  
S. Mitola ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Chemokine Receptor ◽  
Stromal Cell ◽  
Chemokine Receptor Cxcr4 ◽  
Stromal Cell Derived Factor

Differential signalling of the chemokine receptor CXCR4 by stromal cell-derived factor 1 and the HIV glycoprotein in rat neurons and astrocytes

2000 ◽  
Vol 12 (1) ◽  
pp. 117-125 ◽  
Author(s):  
Françoise Lazarini ◽  
Philippe Casanova ◽  
To Nam Tham ◽  
Erik De Clercq ◽  
Fernando Arenzana-Seisdedos ◽  
...  
Keyword(s):  
Chemokine Receptor ◽  
Stromal Cell ◽  
Chemokine Receptor Cxcr4 ◽  
Stromal Cell Derived Factor

The chemokine SDF-1, stromal cell-derived factor 1, attracts early stage B cell precursors via the chemokine receptor CXCR4

1997 ◽  
Vol 27 (7) ◽  
pp. 1788-1793 ◽  
Author(s):  
Massimo D'Apuzzo ◽  
Antonius Rolink ◽  
Marcel Loetscher ◽  
James A. Hoxie ◽  
Ian Clark-Lewis ◽  
...  
Keyword(s):  
B Cell ◽  
Chemokine Receptor ◽  
Stromal Cell ◽  
Early Stage ◽  
Chemokine Receptor Cxcr4 ◽  
Stromal Cell Derived Factor ◽  
B Cell Precursors

scholarly journals Exploratory Studies on Development of the Chemokine Receptor CXCR4 Antagonists toward Downsizing

2008 ◽  
Vol 2 ◽  
pp. PMC.S422 ◽  
Author(s):  
Hirokazu Tamamura ◽  
Hiroshi Tsutsumi ◽  
Wataru Nomura ◽  
Nobutaka Fujii
Keyword(s):  
Rheumatoid Arthritis ◽  
Chemokine Receptor ◽  
Stromal Cell ◽  
Chemokine Receptor Cxcr4 ◽  
Cell Metastasis ◽  
Central Nervous Systems ◽  
Cxcr4 Antagonists ◽  
Stromal Cell Derived Factor ◽  
G Protein Coupled ◽  
Important Therapeutic Target

Seven transmembrane (7TM) G-protein-coupled receptor (GPCR) families are important targets for drug discovery, and specific antagonists for GPCR can accelerate research in the field of medicinal chemistry. The chemokine receptor CXCR4 is a GPCR that possesses a unique ligand CXCL12/stromal cell-derived factor-1 (SDF-1). The interaction between CXCL12 and CXCR4 is essential for the migration of progenitor cells during embryonic development of the cardiovascular, hemopoietic and central nervous systems, and also involved in several intractable disease processes, including HIV infection, cancer cell metastasis, progression of acute and chronic leukemias, rheumatoid arthritis and pulmonary fibrosis. Thus, CXCR4 may be an important therapeutic target in all of these diseases, and various CXCR4 antagonists have been proposed as potential drugs. Fourteen-mer peptides, T140 and its analogs, and downsized cyclic pentapeptides have been developed by us as potent CXCR4 antagonists. This article describes the development of a number of specific CXCR4 antagonists in our laboratory, including downsizing.

Sign in / Sign up

Export Citation Format

Share Document