Biologic differences between squamous cell carcinomas and adenocarcinomas of the lung demonstrated by tissue arrays: Interest for the 18F-FDG-PET.

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. e21087-e21087 ◽  
Author(s):  
K. Areses ◽  
U. Anido ◽  
A. Ruibal ◽  
I. Abdulkader ◽  
F. Gude ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Fdg Pet ◽  
Squamous Cell Carcinomas ◽  
Tissue Arrays ◽  
18F Fdg

HIF expression and Max-SUV-18F-FDG-PET in non-small cell lung cancer (NSCLC) patients

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e22010-e22010
Author(s):  
R. Lopez ◽  
E. Gallardo ◽  
A. Ruibal ◽  
L. Leon ◽  
A. Sanchez-Salmon ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Fdg Pet ◽  
Clinical Stage ◽  
Squamous Cell Carcinomas ◽  
Stage I ◽  
Immunohistochemical Expression ◽  
Small Cell Lung ◽  
Egfr Expression ◽  
18F Fdg ◽  
Nsclc Patients

e22010 Background: Tumor hipoxia induces the up-regulation of several genes via the hipoxia-inducible transcription factors (HIF) 1 and 2. HIF-2 alpha (HIF-2 α) and HIF-1 alpha (HIF-1α) are associated with the prognosis of operable NSCLC patients. We studied the immunohistochemical expression of HIF-1α and HIF-2 α in patients with NSCLC and the possible correlation with the maximum standardised uptake value (max SUV) of 18F-FDG as well as other biological parameters. Methods: We used a Tissue Arrayer device (Beecher Instruments. WI) to construct a TMA block, according to conventional protocols for the study of immunohistochemical expression of HIF-1α, HIF-2 α, EGFR, bcl-2, MIB1, p16, p63 and cyclins A, B1, D1 and D3. Sections were scored as positive if >10% of cells stained positively. Staining patterns were correlated to clinical variables. Results: HIF- 1α expression was observed in 84/96 patients (34/39 adenocarcinomas and 50/57 squamous cell carcinomas), however it did not correlate with clinical stage (I-II: 41/45 vs III-IV: 44/51). HIF-1α correlated positively with HIF-2 α (p:0,001) and EGFR (p:<0,001) expressions. The maxSUV values of 18F-FDG-PET were higher (p:0,039) in HIF-1α -positive (17,1±8,6) than in negative tumors (11,8±4,4). HIF-2 α expression was observed in 60/103 cases (27/42 adenocarcinomas and 33/61 squamous cell carcinomas) and it did not correlate with clinical stage ((I-II: 28/45 vs III-IV: 32/57). HIF-2 α correlated positively with HIF-1α (p:0,001), MIB1 (p:0,045) and EGFR (p:0,091) expressions. After multivariate analysis, only the clinical stage (RR: 2,2) was a prognostic factor. Conclusions: 1) HIF-1α and HIF-2 α expressions are frequent in patients with NSCLCs and it did not correlate with clinical stage; 2) maxSUVs FDG-PET values were higher in HIF1alpha positive than in HIF-1α negative patients; 3) HIF-1α was correlated with EGFR expression, while HIF-2 α was correlated with MIB1 expression. No significant financial relationships to disclose.

CT, MR, 18F-FDG PET/CT, and their combined use for the assessment of mandibular invasion by squamous cell carcinomas of the oral cavity

2010 ◽  
Vol 51 (10) ◽  
pp. 1111-1119 ◽  
Author(s):  
Dong Hyeon Gu ◽  
Dae Young Yoon ◽  
Chan Hee Park ◽  
Suk Ki Chang ◽  
Kyoung Ja Lim ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Squamous Cell ◽  
Fdg Pet ◽  
Squamous Cell Carcinomas ◽  
Combined Use ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Early Response Monitoring with 18F-FDG PET and Cetuximab-F(ab')2-SPECT After Radiotherapy of Human Head and Neck Squamous Cell Carcinomas in a Mouse Model

2014 ◽  
Vol 55 (10) ◽  
pp. 1665-1670 ◽  
Author(s):  
L. K. van Dijk ◽  
O. C. Boerman ◽  
G. M. Franssen ◽  
J. Lok ◽  
J. H. A. M. Kaanders ◽  
...  
Keyword(s):  
Mouse Model ◽  
Head And Neck ◽  
Squamous Cell ◽  
Fdg Pet ◽  
Human Head ◽  
Early Response ◽  
Squamous Cell Carcinomas ◽  
Response Monitoring ◽  
18F Fdg

The association of 18F-FDG PET and glucose metabolism biomarkers GLUT1 and HK2 in p16 positive and negative head and neck squamous cell carcinomas

2015 ◽  
Vol 117 (1) ◽  
pp. 118-124 ◽  
Author(s):  
Andrew M. Baschnagel ◽  
Jessica L. Wobb ◽  
Joshua T. Dilworth ◽  
Lindsay Williams ◽  
Mohammad Eskandari ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Head And Neck ◽  
Squamous Cell ◽  
Fdg Pet ◽  
Squamous Cell Carcinomas ◽  
18F Fdg

scholarly journals Do 18F-FDG PET/CT Parameters in Oropharyngeal and Oral Cavity Squamous Cell Carcinomas Indicate HPV Status?

2015 ◽  
Vol 40 (3) ◽  
pp. e196-e200 ◽  
Author(s):  
Ayse Tuba Karagulle Kendi ◽  
Kelly Magliocca ◽  
Amanda Corey ◽  
Dana C. Nickleach ◽  
James Galt ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Squamous Cell ◽  
Fdg Pet ◽  
Squamous Cell Carcinomas ◽  
Hpv Status ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Diagnostic Accuracy of Combined PET/CT with MRI, 18F-FDG PET/MRI, and 18F-FDG PET/CT in Patients with Oropharyngeal and Hypopharyngeal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Mania Kave ◽  
Kambiz Sadegi ◽  
Fateme Parooie ◽  
Morteza Salarzaei
Keyword(s):  
Diagnostic Accuracy ◽  
Squamous Cell ◽  
Fdg Pet ◽  
Distant Metastases ◽  
Squamous Cell Carcinomas ◽  
Synchronous Cancer ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Ct And Mri

Introduction. The aim of this paper is to compare the diagnostic accuracy of PET/CT, PET/MRI, and the combination of PET/CT and MRI for detecting synchronous cancer and distant metastasis in patients with oropharyngeal and hypopharyngeal squamous cell carcinomas (OHSCC). Method. A large and growing body of literature has been conducted using the Preferred Reporting Items for Systematic Reviews (PRISMA). The researchers collected all accessible literature existing through Cochrane Library (John Wiley & Sons) electronic databases, Embase (Elsevier), PubMed (U.S. National Library of Medicine), Scopus, and Google Scholar up to June 2020. Analyses were conducted using Stata version 12.0 (StataCorp LP). Results. A total of nine studies consisting of 1166 patients were included. The pooled sensitivity of combined PET/CT with MRI, 18F-FDG PET/MRI, and 18F-FDG PET/CT was 0.92, 0.80, and 0.79, respectively, and the corresponding specificities were 0.93, 0.91, and 0.88. The overall prevalence of distant metastases and synchronous cancer in patients with oropharyngeal and hypopharyngeal squamous cell carcinomas was 9.2% and 11.8%, respectively, with the esophagus (4.6%) being the most common site of synchronous cancer. The most common sites of distant metastases were lung (3%), bone (1.2%), and distant lymph nodes (1.2%), respectively. Conclusion. Our study showed an approximately similar diagnostic performance for PET/CT, PET/MRI, and the combination of PET/CT and MRI for metastasis assessment in advanced oropharyngeal and hypopharyngeal squamous cell carcinomas.

scholarly journals Textural Features of Pretreatment 18F-FDG PET/CT Images: Prognostic Significance in Patients with Advanced T-Stage Oropharyngeal Squamous Cell Carcinoma

2013 ◽  
Vol 54 (10) ◽  
pp. 1703-1709 ◽  
Author(s):  
N.-M. Cheng ◽  
Y.-H. Dean Fang ◽  
J. Tung-Chieh Chang ◽  
C.-G. Huang ◽  
D.-L. Tsan ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Fdg Pet ◽  
Prognostic Significance ◽  
Ct Images ◽  
Textural Features ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

18F-FDG PET cannot predict expression of clinically relevant histopathological biomarkers in head and neck squamous cell carcinoma: a meta-analysis

2021 ◽  
pp. 028418512198897
Author(s):  
Alexey Surov ◽  
Maciej Pech ◽  
Alexander Eckert ◽  
Christoph Arens ◽  
Oliver Grosser ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factor ◽  
Tumor Cell ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Fdg Pet ◽  
Neck Squamous Cell Carcinoma ◽  
Histopathological Features ◽  
18F Fdg

Background Head and neck squamous cell carcinoma (HNSCC) is a common cancer. Positron emission tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG) is a widely used imaging modality in HNSCC. Purpose To provide evident data about associations between 18F-FDG PET and histopathology in HNSCC. Material and Methods The MEDLINE database was screened for associations between maximum standard uptake values (SUVmax) derived from 18F-FDG PET and histopathological features in HNSCC up to May 2020. Only papers containing correlation coefficients between SUVmax and histopathology were acquired. Overall, 23 publications were collected. Results The following correlations were calculated: KI 67: 12 studies (345 patients), pooled correlation coefficient (PCC): 0.23 (95% confidence interval [CI] 0.06–0.40); hypoxia-inducible factor-1α: eight studies (240 patients), PCC: 0.24 (95% CI 0.06–0.42); microvessel density: three studies (64 patients), PCC: 0.33 (95% CI 0.02–0.65); vascular endothelial growth factor: two studies (59 cases), PCC: 0.27 (95% CI 0.02–0.51); tumor suppressor protein p53: four studies (159 patients), PCC: 0.05 (95% CI –0.41 to 0.51); epidermal growth factor receptor: two studies (124 patients), PCC: 0.21 (95% CI 0.05–0.37); tumor cell count: three studies (67 patients), PCC: 0.18 (95% CI –0.06 to 0.42); tumor cell apoptosis: two studies (40 patients), PCC: 0.07 (95% CI = –0.85 to 0.99); B-cell lymphoma-2 protein: two studies (118 patients); PCC: 0.04 (95% CI –0.65 to 0.74); glucose-transporter 1: 10 studies (317 patients), PCC: 0.20 (95% CI 0.10–0.30). Conclusion SUVmax derived from 18F-FDG PET cannot reflect relevant histopathological features in HNSCC.

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