scholarly journals Prognostic Significance of Signet Ring Gastric Cancer

2012 ◽  
Vol 30 (28) ◽  
pp. 3493-3498 ◽  
Author(s):  
Sharven Taghavi ◽  
Senthil N. Jayarajan ◽  
Adam Davey ◽  
Alliric I. Willis
Keyword(s):  
United States ◽  
Gastric Cancer ◽  
Alaska Native ◽  
Prognostic Significance ◽  
Distant Metastases ◽  
Tumor Grade ◽  
The United States ◽  
Signet Ring Cell ◽  
Signet Ring ◽  
Worse Prognosis

Purpose Studies in Asia have questioned the dictum that signet ring cell carcinoma (SRC) has a worse prognosis than other forms of gastric cancer. Our study determined differences in presentation and outcomes between SRC and gastric adenocarcinoma (AC) in the United States. Patients and Methods The National Cancer Institute Surveillance, Epidemiology, and End Results database was reviewed for SRC and AC from 2004 to 2007. Results We reviewed 10,246 cases of patients with gastric cancer, including 2,666 of SRC and 7,580 of AC. SRC presented in younger patients (61.9 v 68.7 years; P < .001) and less often in men (52.7% v 68.7%; P < .001). SRC patients were more frequently black (11.3% v 10.9%), Asian (16.4% v 13.2%), American Indian/Alaska Native (0.9% v 0.8%), or Hispanic (23.3% v 14.0%; P < .001). SRC was more likely to be stage T3-4 (45.8% v 33.3%), have lymph node spread (59.7% v 51.8%), and distant metastases (40.2% v 37.6%; P < .001). SRC was more likely to be found in the lower (30.7% v 24.2%) and middle stomach (30.6% v 20.7%; P < .001). Median survival was not different between the two (AC, 14.0 months v SRC, 13.0 months; P = .073). Multivariable analyses demonstrated SRC was not associated with mortality (hazard ratio [HR], 1.05; 95% CI, 0.96 to 1.11; P = .150). Mortality was associated with age (HR, 1.01; 95% CI, 1.01 to 1.02; P < .001), black race (HR, 1.10; 95% CI, 1.01 to 1.20; P = .026), and tumor grade. Variables associated with lower mortality risk included Asian race (HR, 0.83; 95% CI, 0.77 to 0.91; P < .001) and surgery (HR, 0.37; 95% CI, 0.34 to 0.39; P < .001). Conclusion In the United States, SRC significantly differs from AC in extent of disease at presentation. However, when adjusted for stage, SRC does not portend a worse prognosis.

scholarly journals Gastric Cancer Among American Indian and Alaska Native Populations in the United States, 2005–2016

2020 ◽  
Vol 115 (12) ◽  
pp. 1989-1997
Author(s):  
Stephanie C. Melkonian ◽  
Dornell Pete ◽  
Melissa A. Jim ◽  
Donald Haverkamp ◽  
Charles L. Wiggins ◽  
...  
Keyword(s):  
United States ◽  
Gastric Cancer ◽  
American Indian ◽  
Alaska Native ◽  
The United States ◽  
Native Populations

scholarly journals Incidence and Prognostic significance of Signet Ring Cell Histology in Gastric Cancer. A cross sectional study from Turkey: Pure Signet Ring Cell Histology in Gastric Cancer

2020 ◽  
Keyword(s):  
Gastric Cancer ◽  
Overall Survival ◽  
Poor Prognosis ◽  
Prognostic Significance ◽  
Good Prognosis ◽  
Signet Ring Cell ◽  
Stage I ◽  
Stage Iii ◽  
Signet Ring ◽  
Ring Cell

Purpose: The present study aims to evaluate the incidence of signet ring cell (SRC) histology in patients with gastric cancer and its prognostic significance on the disease stage. Methods: Between November 2006 and September 2019, 309 patients were reviewed retrospectively in Kartal Koşuyolu High Specialization Training and Research Hospital Gastroenterology Surgery clinic in Turkey and the clinicopathological features and survival status were examined in the presence of ring cell histology. Results: Of the patients, 71.4% had gastric cancer with a non-SRC histology and 28.6% had an SRC histology. The presence of an SRC histology was found to be associated with young age (p=0.007), advanced depth of wall invasion (p=0.001), number of positive lymph nodes (p=0.022) and presence of vascular invasion (p=0.044). The presence of an SRC histology was associated with good prognosis in patients with stage I gastric cancer (p=0.045), but with poor prognosis in patients with stage III disease (p=0.034). The study found no significant association between stage II disease and overall survival. Conclusions: The present study found survival to be associated with good prognosis in stage I, and poor prognosis in stage III among patients with gastric cancer with SRC histology. No prognostic significance could be established for overall survival.

Patterns of gastric cancer metastasis within the United States.

2020 ◽  
Vol 38 (4_suppl) ◽  
pp. 329-329
Author(s):  
Joseph Sirody ◽  
Amy H. Kaji ◽  
Danielle M. Hari ◽  
Kathryn Tzung-Kai Chen
Keyword(s):  
United States ◽  
Gastric Cancer ◽  
Overall Survival ◽  
Liver Metastases ◽  
Cancer Metastasis ◽  
The United States ◽  
Peritoneal Metastases ◽  
Peritoneal Disease ◽  
Metastatic Site ◽  
Signet Ring

329 Background: There are few reports on the epidemiology of gastric cancer metastasis, although outcomes are known to be uniformly poor. Here we describe the patterns of gastric cancer metastasis and treatment in the United States (US). Methods: Patients with gastric adenocarcinoma histologies were identified in the National Cancer Database (NCDB) from 2004-2016. We describe univariate associations between different sites of metastasis and clinicopathologic characteristics and treatment modalities, using the chi-square and Kruskal-Wallis tests. Kaplan Meier curves were constructed for the estimation of overall survival (OS) by metastatic site. Results: Due to changes in the coding of metastatic disease, we were limited to the year 2016 for evaluation of patterns of disease. Twenty-six percent (n = 1228) of gastric cancer patients presented with liver metastases, 20% (n = 941) with distant nodes, 43% (n = 2028) with other distant site metastases (including peritoneum), and the rest to bone, brain or lung. On univariate analysis, when compared to liver metastases, other distant site metastases were significantly more likely to arise from an antral primary site (28% v. 16%); to be of Hispanic origin (16% v. 7%); female (42% v. 29%); associated with signet ring histology (34% v. 6%); lymphovascular invasion (LVI) (58% v. 27%); and tumor grade III/IV (85% vs. 60%) (p < 0.0001 for all). There were no significant differences in how patients with metastatic disease were treated in terms of systemic therapy. With regard to OS, due to how metastatic sites were coded prior to 2016, it was not possible to compare peritoneal metastases against other sites; however, patients with distant nodal disease had improved median overall survival compared to those with any other metastatic site (7.9 v. 5.2 months, p < 0.0001). Conclusions: The majority of US patients with metastatic gastric cancer present with presumed peritoneal disease. Predictive factors for peritoneal metastases vs. liver metastases included adverse prognostic features, including signet ring histology, higher tumor grades, and LVI. Although it was not possible to compare OS of peritoneal disease against other sites, continued follow up is needed, as this may impact future staging.

scholarly journals Intramucosal Signet Ring Cell Gastric Cancer Diagnosed 15 Months after the Initial Endoscopic Examination

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Keisuke Taniuchi ◽  
Koji Ookawauchi ◽  
Kento Kumon ◽  
Tatsuaki Sumiyoshi ◽  
Jun Iwata ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Distal Gastrectomy ◽  
Immunohistochemical Analysis ◽  
Endoscopic Examination ◽  
Signet Ring Cell ◽  
P53 Mutations ◽  
Ki 67 ◽  
Signet Ring ◽  
Ring Cell ◽  
Worse Prognosis

The size and shape of intramucosal signet ring gastric cancer in this case remained endoscopically unchanged for 15 months. Laparoscopy-assisted distal gastrectomy was performed, and immunohistochemical analysis revealed Ki-67 and p53 mutations to be negative in this case. Signet ring gastric cancer has long been thought to confer a worse prognosis than other forms of gastric cancer; however, our case did not progress to advanced gastric cancer for 15 months.

Incidence, Survival, and Predictors of Lymph Node Metastasis in Early Stage Gastric Signet Ring Cell Carcinomas in the United States

2017 ◽  
Vol 152 (5) ◽  
pp. S1231
Author(s):  
Sridevi K. Pokala ◽  
Zhengjia Chen ◽  
Parit Mekaroonkamol ◽  
Anthony Gamboa ◽  
Steven Keilin ◽  
...  
Keyword(s):  
United States ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Early Stage ◽  
The United States ◽  
Signet Ring Cell ◽  
Node Metastasis ◽  
Signet Ring ◽  
Ring Cell

scholarly journals Signet ring cell carcinoma of the Ampulla of Vater: outcomes of patients in the United States

HPB ◽  
2020 ◽  
Vol 22 (12) ◽  
pp. 1759-1765
Author(s):  
Connor J. Kinslow ◽  
Michael S. May ◽  
Margaret Kozak ◽  
Erqi L. Pollom ◽  
Daniel T. Chang
Keyword(s):  
United States ◽  
Cell Carcinoma ◽  
The United States ◽  
Ampulla Of Vater ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Signet Ring ◽  
Ring Cell
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