Utilization of palliative chemotherapy for advanced bladder cancer: Patterns of care in routine clinical practice.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 6525-6525
Author(s):  
Andrew George Robinson ◽  
Xuejiao Wei ◽  
William J. Mackillop ◽  
Christopher M. Booth
2016 ◽  
Vol 14 (3) ◽  
pp. 291-298 ◽  
Author(s):  
Andrew G. Robinson ◽  
Xuejiao Wei ◽  
William J. Mackillop ◽  
Yingwei Peng ◽  
Christopher M. Booth

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Charles C. Guo ◽  
Jolanta Bondaruk ◽  
Hui Yao ◽  
Ziqiao Wang ◽  
Li Zhang ◽  
...  

Abstract Genomic profiling studies have demonstrated that bladder cancer can be divided into two molecular subtypes referred to as luminal and basal with distinct clinical behaviors and sensitivities to frontline chemotherapy. We analyzed the mRNA expressions of signature luminal and basal genes in bladder cancer tumor samples from publicly available and MD Anderson Cancer Center cohorts. We developed a quantitative classifier referred to as basal to luminal transition (BLT) score which identified the molecular subtypes of bladder cancer with 80–94% sensitivity and 83–93% specificity. In order to facilitate molecular subtyping of bladder cancer in primary care centers, we analyzed the protein expressions of signature luminal (GATA3) and basal (KRT5/6) markers by immunohistochemistry, which identified molecular subtypes in over 80% of the cases. In conclusion, we provide a tool for assessment of molecular subtypes of bladder cancer in routine clinical practice.


2009 ◽  
Vol 7 (2) ◽  
pp. 449
Author(s):  
J. Savva-Bordalo ◽  
M. Ferreira ◽  
A. Araújo ◽  
N. Sousa ◽  
J. Maurício ◽  
...  

2014 ◽  
Vol 26 (8) ◽  
pp. 506-514 ◽  
Author(s):  
C.M. Booth ◽  
D.R. Siemens ◽  
G. Li ◽  
Y. Peng ◽  
W. Kong ◽  
...  

2017 ◽  
Vol 123 ◽  
pp. S224
Author(s):  
T. Brunner ◽  
N. Andratschke ◽  
S. Gerum ◽  
N. Abbasi-Senger ◽  
M. Duma ◽  
...  

2014 ◽  
Vol 25 (9) ◽  
pp. 1783-1788 ◽  
Author(s):  
C.M. Booth ◽  
D.R. Siemens ◽  
Y. Peng ◽  
I.F. Tannock ◽  
W.J. Mackillop

2011 ◽  
Vol 7 (3) ◽  
pp. 225
Author(s):  
Gianfranco Sinagra ◽  
Michele Moretti ◽  
Giancarlo Vitrella ◽  
Marco Merlo ◽  
Rossana Bussani ◽  
...  

In recent years, outstanding progress has been made in the diagnosis and treatment of cardiomyopathies. Genetics is emerging as a primary point in the diagnosis and management of these diseases. However, molecular genetic analyses are not yet included in routine clinical practice, mainly because of their elevated costs and execution time. A patient-based and patient-oriented clinical approach, coupled with new imaging techniques such as cardiac magnetic resonance, can be of great help in selecting patients for molecular genetic analysis and is crucial for a better characterisation of these diseases. This article will specifically address clinical, magnetic resonance and genetic aspects of the diagnosis and management of cardiomyopathies.


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