Biochemical failure after treatment for localized prostate cancer: Does original therapeutic modality affect long-term survival?

2015 ◽  
Vol 33 (7_suppl) ◽  
pp. 65-65
Author(s):  
Chad A. Reichard ◽  
Evan Kovac ◽  
Jay P. Ciezki ◽  
Rahul D. Tendulkar ◽  
Eric A. Klein ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Overall Survival ◽  
Biochemical Failure ◽  
Localized Prostate Cancer ◽  
Definitive Treatment ◽  
Rank Test ◽  
Cancer Specific Survival ◽  
Term Survival ◽  
Long Term Survival

65 Background: Mortality among men with biochemical failure (BF) after treatment is variable. We examined the long-term survival of men with BF to determine if differences exist, depending on original treatment modality. Methods: Between 1995 and 2008, 6,084 patients underwent treatment for clinically localized prostate cancer at our institution (4,276 underwent radical prostatectomy (RP); 1,808 underwent EBRT). Clinical information and follow up data was obtained from prospectively maintained databases. Survival was assessed using log rank test. Results: 526 (12%) patients had BF defined by PSA > 0.4 after RP. 326 (18%) patients had BF after EBRT, defined as PSA nadir +2. 197 (60%) of EBRT patients received ADT as neoadjuvant/concurrent/adjuvant therapy. Median overall survival was 154 months (95%CI 148-157) versus 129 months (95%CI 123-135) for RP and EBRT respectively (p<.0001). Median prostate cancer specific survival was 125 months (95%CI 93-148) versus 107 months (95%CI 92-123) for RP and EBRT respectively (p=0.17). There was no difference in prostate cancer specific survival between treatments among patients in D’Amico intermediate and high risk groups. Conclusions: In patients with biochemical recurrence after definitive treatment, patients treated with RP have improved overall survival compared to patients treated with EBRT. However, there is no difference among treatment groups in prostate cancer specific survival.

Long-term survival following radical prostatectomy in Japanese men with clinically localized prostate cancer: A single institutional study

2004 ◽  
Vol 11 (10) ◽  
pp. 862-869 ◽  
Author(s):  
TAKAHIKO HACHIYA ◽  
YASUHIRO OKADA ◽  
NOZOMU KAWATA ◽  
DAISAKU HIRANO ◽  
TOSHIO YOSHIDA ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Localized Prostate Cancer ◽  
Term Survival ◽  
Japanese Men ◽  
Long Term Survival

The influence of race and treatment choice in 16,508 men treated either conservatively, with radiotherapy, or surgically for clinically localized prostate cancer.

2011 ◽  
Vol 29 (7_suppl) ◽  
pp. 210-210
Author(s):  
P. Sooriakumaran ◽  
T. Field ◽  
M. John ◽  
R. Leung ◽  
A. Tewari
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Watchful Waiting ◽  
The United States ◽  
Research Network ◽  
Localized Prostate Cancer ◽  
Term Survival ◽  
Long Term Survival ◽  
Treatment Choices

210 Background: There are known variations in cancer survival based on race and treatment choices. We report the long-term survival probability, based on race, in 16,508 men with localized prostate cancer treated either conservatively or by radiotherapy or radical prostatectomy. Methods: We extracted survival data from tumor registries of six Cancer Research Network sites in the United States. Patients were stratified into four racial groups: Caucasians, African Americans, Hispanics, and Asians. The Cox proportional-hazards regression model was used to compare long-term survival in the three treatment groups. Kaplan-Meier survival curves and competing risk analysis was also performed. Results: Survival was improved for patients who underwent radical prostatectomy compared to radiotherapy or watchful waiting. This was true for all patients combined (Table) as well as for all races individually. Radiotherapy had at least equivalent survival outcomes as watchful waiting in all groups. The differences between treatments were greater for overall survival than for prostate cancer specific survival in all groups, though the extent of the differences varied by race. Conclusions: Radical prostatectomy increases survival in men with localized prostate cancer compared to both radiotherapy and watchful waiting, especially for Caucasian men. Radiotherapy was at least equivalent to watchful waiting for all races. Racial disparities in outcome may influence treatment choices for men with clinically localized prostate cancer. [Table: see text] [Table: see text]

scholarly journals Can local treatment prolong the sensitivity of metastatic prostate cancer to androgen deprivation or even prevent castration resistance?

2021 ◽  
Author(s):  
Christina Niklas ◽  
Matthias Saar ◽  
Alessandro Nini ◽  
Johannes Linxweiler ◽  
Stefan Siemer ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Overall Survival ◽  
Biochemical Recurrence ◽  
Metastatic Prostate Cancer ◽  
Locally Advanced ◽  
Survival Rates ◽  
Term Survival ◽  
Long Term Survival ◽  
Hormonal Manipulation

Abstract Purpose A number of observational clinical studies suggest that prior primary tumor treatment favorably influences the course of metastatic prostate cancer (PCa), but its mechanisms of action are still speculative. Here, we describe the long-lasting sensitivity to various forms of androgen deprivation in patients after radical prostatectomy (RP) for locally advanced PCa as one potential mechanism. Methods A consecutive series of 115 radical prostatectomies after inductive therapy for T4 prostate cancer was re-analyzed, and long-term survival, as well as recurrence patterns and responses to different forms of hormonal manipulation, were assessed. Results The estimated biochemical response-free, PCa-specific, and overall survival rates after 200 months were 20%, 65%, and 47% with a median overall survival of 156 months. The majority of patients, although not cured of locally advanced PCa (84/115), showed long-term survival after RP. PCa-specific and overall survival rates of these 84 patients with biochemical recurrence were 61% and 44% at 150 months. Long-term sensitivity to ADT was found to be the main reason for the favorable tumor-specific survival in spite of biochemical recurrence. Conclusions Sensitivity to primary or secondary hormonal manipulation was the main reason for the long-term survival of patients who had not been cured by surgery only. The results suggest that treatment of the primary tumor-bearing prostate delays castration-resistant PCa and enhances the effect of hormonal therapies in a previously unknown manner. The underlying cellular and molecular mechanisms need to be explored in more detailed analyses, which could profoundly impact treatment concepts of locally advanced and metastatic PCa.

scholarly journals 385: Impact of Socioeconomic Factors on long-term Survival in Patients with Clinically Localized Prostate Cancer

2007 ◽  
Vol 177 (4S) ◽  
pp. 128-128
Author(s):  
Peter Chang ◽  
Ashutosh K. Tewari ◽  
Heather T. Gold ◽  
Wolfgang Hominger ◽  
Alexandre E. Pelzer ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Socioeconomic Factors ◽  
Localized Prostate Cancer ◽  
Term Survival ◽  
Long Term Survival
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