Combined impact of diet and lifestyle after diagnosis on risk of prostate cancer death.

2016 ◽  
Vol 34 (2_suppl) ◽  
pp. 159-159 ◽  
Author(s):  
Stacey A. Kenfield
Keyword(s):  
Prostate Cancer ◽  
Processed Meat ◽  
Cruciferous Vegetables ◽  
Vigorous Activity ◽  
Cancer Death ◽  
Healthy Weight ◽  
Total Diet ◽  
Prostate Cancer Death ◽  
Diet And Lifestyle

159 Background: Several lifestyle factors have been independently associated with prostate cancer progression and mortality, but little is known about their combined effect.Our objective wasto develop scores based on post-diagnostic diet and lifestyle behaviors for the prevention of prostate cancer death. Methods: We developed four scores (food-only: range 0-5; food & drinks: range 0-8; lifestyle-only: range 0-3; food, drinks & lifestyle: range 0-11) among 3,583 men in the Health Professionals Follow-Up Study diagnosed with non-metastatic prostate cancer in 1986-2008 with follow-up through 2012. Potential factors and their cut-points were based on the literature. One point was given for each factor: not currently smoking or quit ≥ 10 years ago, BMI < 30 kg/m2, ≥ 3 h/wk vigorous activity or ≥ 7 h/wk brisk walking, ≥ 1 serv/d cruciferous vegetables, ≥ 3 serv/wk nuts or oil-based dressings, ≥ 4 cups/d coffee, ≥ 7 serv/wk wine, < 2 serv/wk processed meat, 0 serv/wk poultry with skin or poultry sandwiches, and < 140 ug/d of supplemental selenium. We used multivariable Cox proportional hazards regression. Results: We observed 240 prostate cancer deaths during a median of 11 years follow-up. A 1-unit increase in each score was associated with a similar reduction in risk of prostate cancer death: food-only (HR = 0.71; 95%CI = 0.60,0.85); food & drinks (HR = 0.71; 95%CI = 0.61,0.82); lifestyle-only (HR = 0.72; 95%CI = 0.56,0.92); and total diet & lifestyle (HR = 0.71; 95%CI = 0.63,0.81). Men with 3 vs 0-1 points for the lifestyle-only score had a 51% decreased risk of prostate cancer death (95%CI = 0.28,0.83); men with ≥ 5 vs 0-2 points on the food & drinks score had a 73% decreased risk of prostate cancer death (95%CI = 0.14,0.51); and men with 4-7 and 8-11 vs 0-3 points for the total diet & lifestyle score had a 48% (95%CI = 0.32,0.84) and 75% (95%CI = 0.09,0.69) decreased risk of prostate cancer death. Conclusions: Adhering toa lifestyle characterized by frequent vigorous activity; not smoking; a healthy weight; a diet rich in cruciferous vegetables, healthy fats from vegetable sources, coffee, and wine and low in processed meat and poultry with skin; and avoiding excess supplemental selenium after prostate cancer diagnosis may lower risk of prostate cancer death.

scholarly journals Prostate cancer prognosis after initiation of androgen deprivation therapy among statin users. A population-based cohort study

2021 ◽  
Author(s):  
A. I. Peltomaa ◽  
P. Raittinen ◽  
K. Talala ◽  
K. Taari ◽  
T. L. J. Tammela ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Deprivation Therapy ◽  
Cancer Prognosis ◽  
Cancer Death ◽  
Psa Relapse ◽  
Prostate Cancer Death ◽  
Study Population ◽  
Statin Use ◽  
Prostate Cancer Prognosis

Abstract Purpose Statins’ cholesterol-lowering efficacy is well-known. Recent epidemiological studies have found that inhibition of cholesterol synthesis may have beneficial effects on prostate cancer (PCa) patients, especially patients treated with androgen deprivation therapy (ADT). We evaluated statins’ effect on prostate cancer prognosis among patients treated with ADT. Materials and methods Our study population consisted of 8253 PCa patients detected among the study population of the Finnish randomized study of screening for prostate cancer. These were limited to 4428 men who initiated ADT during the follow-up. Cox proportional regression model adjusted for tumor clinical characteristics and comorbidities was used to estimate hazard ratios for risk of PSA relapse after ADT initiation and prostate cancer death. Results During the median follow-up of 6.3 years after the ADT initiation, there were 834 PCa deaths and 1565 PSA relapses in a study cohort. Statin use after ADT was associated with a decreased risk of PSA relapse (HR 0.73, 95% CI 0.65–0.82) and prostate cancer death (HR 0.82; 95% CI 0.69–0.96). In contrast, statin use defined with a one-year lag (HR 0.89, 95% CI 0.76–1.04), statin use before ADT initiation (HR 1.12, 95% CI 0.96–1.31), and use in the first year on ADT (HR 1.02, 95% CI 0.85–1.24) were not associated with prostate cancer death, without dose dependency. Conclusion Statin use after initiation of ADT, but not before, was associated with improved prostate cancer prognosis.

scholarly journals MUC-1 gene is associated with prostate cancer death: a 20-year follow-up of a population-based study in Sweden

2007 ◽  
Vol 97 (6) ◽  
pp. 730-734 ◽  
Author(s):  
O Andrén ◽  
K Fall ◽  
S-O Andersson ◽  
M A Rubin ◽  
T A Bismar ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Population Based ◽  
Cancer Death ◽  
Population Based Study ◽  
Prostate Cancer Death

Active surveillance of postradical prostatectomy biochemical recurrence: Long-term assessment of outcomes.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 5081-5081
Author(s):  
Tom Edward Ahlering ◽  
Erica Huang ◽  
Linda My Huynh ◽  
Huang Wei Su
Keyword(s):  
Prostate Cancer ◽  
Active Surveillance ◽  
Biochemical Recurrence ◽  
Treatment Intervention ◽  
Cancer Death ◽  
Metastatic Progression ◽  
Prostate Cancer Death ◽  
Long Term Experience

5081 Background: Biochemical recurrence (BCR) following radical prostatectomy (RP) is an unreliable predictor of distant metastatic progression/prostate cancer death, resulting in potential complications & expenses of overtreatment. Little has been published on management decisions & outcomes of active surveillance (AS). We characterize our long term experience with AS following post-RP BCR without radiation/androgen deprivation therapy. Methods: From June 2002 - September 2019, 1865 men underwent RP. 406 experienced BCR; of these, 138 (34%) were observed without treatment intervention. BCR defined as PSA>0.2 ng/dl, x2. PSAs checked every 1-3 months and entered into a PSADT graph. Men were considered to be formally AS after 3+ years of increasing DT following RP. Men with decreasing DT were treated and censored. Results: The table depicts demographics of the AS patients; median follow-up was 7.3 years (IQR: 4.6-10.6) post-RP. Of patients on AS, average age was 63.7 +/- 7.2 years and 86%, 48%, 40%, 51% and 14% were GG 1 through 5, respectively. Current DT of AS patients averages 20 months, with 0% PCSM. Only 10% of patients with decreasing DT began treatment after average 4 years following BCR. Conclusions: Of 406 patients experiencing post-RP BCR, 34% of patients are effectively managed with AS, with 0% PCSM across all GG. Presently 69 (50%) AS men have been under observation for 7.3 to 18 years. This suggests that significant portion of patients display benign recurrence, characterized by increasing DT following BCR and can be managed safely with observation alone.[Table: see text]

scholarly journals Duration of Androgen Suppression Before Radiotherapy for Localized Prostate Cancer: Radiation Therapy Oncology Group Randomized Clinical Trial 9910

2015 ◽  
Vol 33 (4) ◽  
pp. 332-339 ◽  
Author(s):  
Thomas M. Pisansky ◽  
Daniel Hunt ◽  
Leonard G. Gomella ◽  
Mahul B. Amin ◽  
Alexander G. Balogh ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Survival Rates ◽  
Intermediate Risk ◽  
Cancer Death ◽  
Disease Specific Survival ◽  
Risk Prostate Cancer ◽  
Prostate Cancer Death ◽  
Androgen Suppression ◽  
Disease Specific

Purpose To determine whether prolonged androgen suppression (AS) duration before radiotherapy improves survival and disease control in prostate cancer. Patients and Methods One thousand five hundred seventy-nine men with intermediate-risk prostate cancer were randomly assigned to 8 weeks of AS followed by radiotherapy with an additional 8 weeks of concurrent AS (16 weeks total) or to 28 weeks of AS followed by radiotherapy with an additional 8 weeks of AS (36 weeks total). The trial sought primarily to detect a 33% reduction in the hazard of prostate cancer death in the 28-week assignment. Time-to-event end points are reported for up to 10 years of follow-up. Results There were no between-group differences in baseline characteristics of 1,489 eligible patients with follow-up. For the 8- and 28-week assignments, 10-year disease-specific survival rates were 95% (95% CI, 93.3% to 97.0%) and 96% (95% CI, 94.6% to 98.0%; hazard ratio [HR], 0.81; P = .45), respectively, and 10-year overall survival rates were 66% (95% CI, 62.0% to 69.9%) and 67% (95% CI, 63.0% to 70.8%; HR, 0.95; P = .62), respectively. For the 8- and 28-week assignments, 10-year cumulative incidences of locoregional progression were 6% (95% CI, 4.3% to 8.0%) and 4% (95% CI, 2.5% to 5.7%; HR, 0.65; P = .07), respectively; 10-year distant metastasis cumulative incidences were 6% (95% CI, 4.0% to 7.7%) and 6% (95% CI, 4.0% to 7.6%; HR, 1.07; P = .80), respectively; and 10-year prostate-specific antigen–based recurrence cumulative incidences were 27% (95% CI, 23.1% to 29.8%) and 27% (95% CI, 23.4% to 30.3%; HR, 0.97; P = .77), respectively. Conclusion Extending AS duration from 8 weeks to 28 weeks before radiotherapy did not improve outcomes. A lower than expected prostate cancer death rate reduced ability to detect a between-group difference in disease-specific survival. The schedule of 8 weeks of AS before radiotherapy plus 8 weeks of AS during radiotherapy remains a standard of care in intermediate-risk prostate cancer.

2243 COMBINED VALUE OF GENOMIC BIOMARKERS AND CAPRA-S IN PREDICTING PROSTATE CANCER DEATH IN A HIGH-RISK SURGICAL COHORT

2013 ◽  
Vol 189 (4S) ◽  
Author(s):  
Matthew Cooperberg ◽  
Anamaria Crisan ◽  
Anirban Mitra ◽  
Mercedeh Ghadessi ◽  
Christine Buerki ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Cancer Death ◽  
Genomic Biomarkers ◽  
Prostate Cancer Death

scholarly journals Application of Neutrosophic Logic to Evaluate Correlation between Prostate Cancer Mortality and Dietary Fat Assumption

Symmetry ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 330 ◽  
Author(s):  
Muhammad Aslam ◽  
Mohammed Albassam
Keyword(s):  
Prostate Cancer ◽  
Dietary Fat ◽  
Death Rate ◽  
Prostate Cancer Risk ◽  
Cancer Death ◽  
Classical Statistics ◽  
Cancer Death Rate ◽  
Prostate Cancer Death ◽  
Fat Level ◽  
Uncertainty Environment

This paper presents an epidemiological study on the dietary fat that causes prostate cancer in an uncertainty environment. To study this relationship under the indeterminate environment, data from 30 countries are selected for the prostate cancer death rate and dietary fat level in the food. The neutrosophic correlation and regression line are fitted on the data. We note from the neutrosophic analysis that the prostate cancer death rate increases as the dietary fat level in the people increases. The neutrosophic regression coefficient also confirms this claim. From this study, we conclude that neutrosophic regression is a more effective model under uncertainty than the regression model under classical statistics. We also found a statistical correlation between dietary fat and prostate cancer risk.

scholarly journals Ki-67 is an independent predictor of prostate cancer death in routine needle biopsy samples: proving utility for routine assessments

2019 ◽  
Vol 32 (9) ◽  
pp. 1303-1309 ◽  
Author(s):  
Solène-Florence Kammerer-Jacquet ◽  
Amar Ahmad ◽  
Henrik Møller ◽  
Holly Sandu ◽  
Peter Scardino ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Needle Biopsy ◽  
Independent Predictor ◽  
Cancer Death ◽  
Ki 67 ◽  
Prostate Cancer Death
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