The relationship between IL-33 and monocyte-macrophages in esophageal squamous cell carcinoma.

Abstract Background Numerous studies reported the prognostic significance of neutrophil count (or preferably NLR) in patients with esophageal squamous cell carcinoma (ESCC), while the relationship between perioperative change in neutrophil count and survival of patients with ESCC after surgery has not been assessed. Methods A total of 603 patients with newly diagnosed ESCC after the operation were enrolled in the study. Neutrophil change (Nc) (Nc = Post-Neutrophil–Pre-Neutrophil) was counted according to data within one week before surgery and two week after surgery. The median of Nc was selected to be the cut off value to evaluate the relationship between Nc and Overall survival (OS). Results 105 (17.4%) patients had pathological stage 1a-1b, 205 (34.0%) patients had pathological stage 2a-2b, and 293 (48.6%) patients had pathological stage 3a-3c.There were 180 (29.9%) patients who had vessel invasive, and 423 (70.1%) patients without vessel invasive. There were 215(35.7%) patients who had nerve infiltration, and 388 (64.3%) without nerve infiltration. In univariate analysis, six parameters including neutrophil change(Nc)(≥ 2.60 vs.<2.60) (P = 0.010, HR = 0.694, 95% CI 0.526–0.915) significantly correlated to worse OS. Multivariate analysis revealed that neutrophil change(Nc)(≥ 2.60 vs.<2.60) was an independent prognostic marker for OS (P = 0.022, HR = 0.720, 95% CI 0.544–0.954). Kaplan-Meier curves shown that Nc < 2.60 was significantly associated with worse OS (P = 0.016). Conclusions Perioperative change in neutrophil count predicts worse survival in patients with ESCC after the operation.

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The Relationship between the Glucose Transporter Type 1 Expression and 18F-Fluorodeoxyglucose Uptake in Esophageal Squamous Cell Carcinoma

Oncology ◽

10.1159/000207505 ◽

2009 ◽

Vol 76 (4) ◽

pp. 286-292 ◽

Cited By ~ 19

Author(s):

Yukiharu Hiyoshi ◽

Masayuki Watanabe ◽

Yu Imamura ◽

Youhei Nagai ◽

Yoshifumi Baba ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Glucose Transporter ◽

The Relationship

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FoXA2 promotes esophageal squamous cell carcinoma progression by ZEB2 activation

World Journal of Surgical Oncology ◽

10.1186/s12957-021-02358-4 ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Hanjing Gao ◽

Zheng Yan ◽

Haiyan Sun ◽

Yanfang Chen

Keyword(s):

Squamous Cell Carcinoma ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Critical Role ◽

Luciferase Reporter ◽

Potential Candidate ◽

Invasion And Migration ◽

And Migration ◽

The Relationship

Abstract Background It has been reported that Forkhead transcription family member (FOXA2) regulates esophageal squamous cell carcinoma (ESCC) progression. However, the specific mechanism, by which FOXA2 promotes ESCC malignant progression, remains unclear. Materials and methods QRT-PCR and western blotting were applied to measure FOXA2 expression in ESCC tissues, while CCK-8 assay and Transwell assays were used to investigate the effect of FOXA2 on ESCC. Luciferase reporter assay, followed by fast chromatin immunoprecipitation (ChIP) assay, was used to study the relationship between FOXA2 and ZEB2. Results FOXA2 was significantly increased in ESCC tissues, when compared to normal tissues. Moreover, high expression of FOXA2 was also found in ESCC cells. Knockdown of FOXA2 inhibited ESCC cell proliferation, invasion, and migration. Mechanically, FOXA2 was verified to regulate ZEB2 expression at transcription level. Moreover, ZEB2 reversed the inhibitory effect of FOXA2 on ESCC proliferation, invasion, and migration. The relationship between ZEB2 and FOXA2 in ESCC tissues was negative. Conclusions These results indicate that FOXA2 plays a critical role in ESCC progression and may become a potential candidate target for ESCC treatment.

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