Changes in T lymphocyte subsets in different tumors before and after radiotherapy: A meta-analysis.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 2525-2525
Author(s):  
Xiaoxia Zhu ◽  
Qin Wang ◽  
Shangbiao Li ◽  
Simiao Qiao ◽  
Zhihao Zheng ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Head And Neck Cancer ◽  
T Lymphocytes ◽  
Liver Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Meta Analysis ◽  
Tumor Patients ◽  
Cd8 T Lymphocytes ◽  
Before And After

2525 Background: Radiation therapy (RT) induces an immune response, but the relationship of this response with tumor type is not fully understood. Methods: We searched English-language electronic databases including PubMed, EMBASE, and the Cochrane Library to collect studies about the changes in CD3+ T lymphocytes, CD4+ T lymphocytes, and CD8+ T lymphocytes before and after radiotherapy in tumor patients from January 2015 to December 2019. The quality of the included literature was evaluated using the NOS scale provided by the Cochrane Collaboration, and statistical software RevMan 5.4 was used to analyze the included literature. p < 0.05 was considered to indicate statistical significance. Results: A total of 17 studies in 15 articles involving 1735 tumor patients were included. All data were collected within 1 month before or after radiotherapy. Meta-analysis showed that numbers of CD3+ T lymphocytes were significantly reduced after radiotherapy compared with before treatment (standard mean difference [SMD]: -0.76; 95% CI [-1.46, -0.06]; p = 0.03), as were those of CD4+ T lymphocytes (SMD: -0.50; 95% CI: [-0.88, -0.12]; p = 0.01), but there was no statistically significant difference for CD8+ T lymphocytes (SMD: 0.19; 95% CI: [-0.23, 0.62]; p = 0.38). Subgroup analysis showed significant decreases in CD3+ T lymphocytes in liver cancer,esophageal cancer, head and neck cancer, pancreatic cancer and breast cancer after radiotherapy. Numbers of CD4+T lymphocytes increased after radiotherapy in breast cancer,and a decrease was observed in liver cancer, esophageal cancer, colorectal cancer, and head and neck cancer. CD8+ T lymphocyte numbers also increased compared with before radiotherapy in esophageal cancer, lung cancer, and colorectal cancer. But a decrease in liver cancer and head and neck cancer. Conclusions: Numbers of CD3+ and CD4+ T lymphocytes decreased after radiotherapy, whereas CD8+ T lymphocytes showed no significant change. Within 1 month of radiotherapy, the tumor microenvironment showed an immunosuppressive state. The degree of immune response induced by radiotherapy differed between tumor types.

scholarly journals Spontaneous apoptosis of tumor-specific tetramer+CD8+T lymphocytes in the peripheral circulation of patients with head and neck cancer

Head & Neck ◽  
2009 ◽  
Vol 31 (6) ◽  
pp. 773-781 ◽  
Author(s):  
Andreas E. Albers ◽  
Carsten Schaefer ◽  
Carmen Visus ◽  
William Gooding ◽  
Albert B. DeLeo ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
T Lymphocytes ◽  
Head And Neck ◽  
Neck Cancer ◽  
Peripheral Circulation ◽  
Spontaneous Apoptosis ◽  
Cd8 T Lymphocytes

scholarly journals Genetic Polymorphisms in the RAD51 Gene with a Risk of Head and Neck Cancer and Esophageal Cancer: A Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Lin Li ◽  
Xue Zhang ◽  
Zhong-Ti Zhang
Keyword(s):  
Esophageal Cancer ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Web Of Science ◽  
Meta Analysis ◽  
Rad51 Gene ◽  
Increased Risk ◽  
Stratified Analysis

Background. The role of RAD51 gene polymorphisms with the development of head and neck cancer (HNC) and esophageal cancer (EC) remains controversial. This meta-analysis was conducted to evaluate the correlation between the RAD51 polymorphisms and these two cancers quantitatively. Methods. Databases of PubMed, Web of Science, and Embase were used to search relevant papers prior to August 17, 2019. STATA 11.0 was performed to observe the correlation. Results. Ten relevant papers were enrolled in our analysis. Overall, a significant correlation was observed between the rs1801320 polymorphism and the increased risk of these two cancers (OR=1.32, 95%CI=1.03‐1.71 for C vs. G; OR=1.50, 95%CI=1.03‐2.19 for CG vs. GG; and OR=1.44, 95%CI=1.05‐1.99 for CC+CG vs. GG). In subgroup analyses, an increased risk was found for EC (OR=2.07, 95%CI=1.01‐4.25 for C vs. G; OR=2.08, 95%CI=1.17‐3.71 for CC vs. GG; and OR=1.78, 95%CI=1.00‐3.15 for CC vs. CG+GG), but not for HNC. Moreover, our analysis revealed that no statistical evidence of correlation was discovered between the polymorphism of rs1801321 and the increased risk of HNC. However, stratified analysis based on ethnicity suggested that rs1801321 polymorphism was related to the decreased risk of HNC among Caucasians (OR=0.82, 95%CI=0.72‐0.95 for T vs. G). Conclusions. rs1801320 polymorphism was strongly associated with the risk of these two associated cancers, especially with esophageal cancer. Moreover, our results revealed that rs1801321 polymorphism was correlated to the decreased risk of HNC among Caucasians.

scholarly journals Changes in T Lymphocyte Subsets in Different Tumors Before and After Radiotherapy: A Meta-analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Qin Wang ◽  
Shangbiao Li ◽  
Simiao Qiao ◽  
Zhihao Zheng ◽  
Xiaotong Duan ◽  
...  
Keyword(s):  
Immune Response ◽  
T Lymphocytes ◽  
T Lymphocyte ◽  
Peripheral Blood ◽  
Lymphocyte Subsets ◽  
Meta Analysis ◽  
Tumor Patients ◽  
T Lymphocyte Subsets ◽  
Cd8 T Lymphocytes ◽  
Before And After

PurposeRadiation therapy (RT) induces an immune response, but the relationship of this response with tumor type is not fully understood. This meta-analysis further elucidated this relationship by analyzing the changes in T lymphocyte subsets in different tumors before and after radiotherapy.MethodsWe searched English-language electronic databases including PubMed, EMBASE, and the Cochrane Library to collect studies on the changes in peripheral blood CD3+ T lymphocytes, CD4+ T lymphocytes, and CD8+ T lymphocytes before and after radiotherapy in tumor patients from January 2015 to April 2021. The quality of the included literature was evaluated using the NOS scale provided by the Cochrane Collaboration, and statistical software RevMan 5.4 was used to analyze the included literature. P&lt;0.05 was considered to indicate statistical significance.ResultsA total of 19 studies in 16 articles involving 877 tumor patients were included. All data were collected within 1 month before or after radiotherapy. Meta-analysis showed that numbers of CD3+ T lymphocytes (SMD: -0.40; 95% CI [-0.75, -0.04]; p = 0.03) and CD4+ T lymphocytes (SMD: -0.43; 95% CI: [-0.85, -0.02]; p = 0.04) were significantly reduced after radiotherapy compared with before treatment, but there was no statistically significant difference for CD8+ T lymphocytes (SMD: 0.33; 95% CI: [-0.88, 0.74]; p = 0.12). Subgroup analysis showed that peripheral blood T lymphocytes decreased in head and neck cancer. However, in prostate cancer and breast cancer, there was no significant change in peripheral blood. 1 month after radiotherapy, it has a potential proliferation and activation effect on lymphocytes in esophageal cancer and lung cancer. The results showed that CD8+T lymphocytes increased in peripheral blood after SBRT. Radiotherapy alone reduced CD3+ T lymphocyte numbers.ConclusionsWithin 1 month of radiotherapy, patients have obvious immunological changes, which can cause apoptosis and reduction of T lymphocytes, and affect the balance of peripheral blood immune cells. The degree of immune response induced by radiotherapy differed between tumor types.

NUTRITION ASSESSMENT IN HEAD AND NECK CANCER PATIENTS PRE and POST CHEMORADIOTHERAPY.

2019 ◽  
Vol 2 (2) ◽  
Author(s):  
Piyush Kumar ◽  
Bhavya P Pateneedi ◽  
Dharam P Singh ◽  
Arvind K Chauhan
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Nutritional Risk ◽  
Total Leukocyte Count ◽  
Risk Indicator ◽  
Anthropometric Parameters ◽  
Skin Fold Thickness ◽  
Before And After

INTRODUCTION: Head and neck cancer patients are frequently malnourished at the time of diagnosis and prior to the beginning of treatment. Deterioration of the nutritional status results in an increase in chemo radiotherapy related toxicity and this may increase the prolonged treatment time, which has been associated with poor clinical outcome. The present study aims to do nutritional assessment before and after chemo radiotherapy in head and neck cancer patients. MATERIAL AND METHODS: The present study was undertaken at the Department of Radiation Oncology, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly. In this study, 50 patients of Head and neck tumours were enrolled and their nutrition was assessed before and after chemoradiotherapy. Nutrition assessment was done using different laboratory parameters like haemoglobin, total leukocyte count, blood urea, serum creatinine and serum bilirubin. Anthropometric parameters used are Body mass index, Skin fold thickness, and Mid-arm circumference. Nutritional risk indicator and PG-SGA score is measured before and after chemoradiotherapy. All the parameters were assessed and analysed using different statistical tests- Chi-square test, Fisher Exact test and paired t test.RESULTS: Haemoglobin decrease was statistically significant during treatment (p less than 0.001) and the decrease in total leukocyte count during treatment was showing trend towards significance (p value-0.056). There was deterioration in other parameters like blood urea, serum creatinine and serum bilirubin but was not statistically significant. Anthropometric parameters- Body mass index, mid-arm circumference and skin fold thickness and percent body fat showed a significant change (p less than 0.00001). Nutritional risk indicator and PG-SGA class has decreased for majority of patients during treatment, the change is statistically significant (p less than 0.00001 and p=0.0251) respectively.CONCLUSION: The nutrition has important role to play in the management of head and neck cancers by chemo radiotherapy. It helps to reduce the complications and improve the tolerance of chemo radiotherapy, thus avoiding treatment breaks which may lead to failure of treatment.

High rates of postoperative radiotherapy delay in head and neck cancer before and after Medicaid expansion

Head & Neck ◽  
2021 ◽  
Author(s):  
John Pang ◽  
Farhoud Faraji ◽  
Erik Risa ◽  
Loren K. Mell ◽  
Jeffrey J. Houlton ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Postoperative Radiotherapy ◽  
Medicaid Expansion ◽  
Before And After

scholarly journals Salivary DNA Methylation as an Epigenetic Biomarker for Head and Neck Cancer. Part I: A Diagnostic Accuracy Meta-Analysis

2021 ◽  
Vol 11 (6) ◽  
pp. 568
Author(s):  
Óscar Rapado-González ◽  
Cristina Martínez-Reglero ◽  
Ángel Salgado-Barreira ◽  
Laura Muinelo-Romay ◽  
Juan Muinelo-Lorenzo ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Head And Neck Cancer ◽  
Diagnostic Accuracy ◽  
Head And Neck ◽  
Likelihood Ratio ◽  
Neck Cancer ◽  
Meta Analysis ◽  
Positive Likelihood Ratio ◽  
Epigenetic Mechanism ◽  
Cochrane Library

DNA hypermethylation is an important epigenetic mechanism for gene expression inactivation in head and neck cancer (HNC). Saliva has emerged as a novel liquid biopsy representing a potential source of biomarkers. We performed a comprehensive meta-analysis to evaluate the overall diagnostic accuracy of salivary DNA methylation for detecting HNC. PubMed EMBASE, Web of Science, LILACS, and the Cochrane Library were searched. Study quality was assessed by the Quality Assessment for Studies of Diagnostic Accuracy-2, and sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (dOR), and their corresponding 95% confidence intervals (CIs) were calculated using a bivariate random-effect meta-analysis model. Meta-regression and subgroup analyses were performed to assess heterogeneity. Eighty-four study units from 18 articles with 8368 subjects were included. The pooled sensitivity and specificity of salivary DNA methylation were 0.39 and 0.87, respectively, while PLR and NLR were 3.68 and 0.63, respectively. The overall area under the curve (AUC) was 0.81 and the dOR was 8.34. The combination of methylated genes showed higher diagnostic accuracy (AUC, 0.92 and dOR, 36.97) than individual gene analysis (AUC, 0.77 and dOR, 6.02). These findings provide evidence regarding the potential clinical application of salivary DNA methylation for HNC diagnosis.

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