Genetic Polymorphisms in the RAD51 Gene with a Risk of Head and Neck Cancer and Esophageal Cancer: A Meta-Analysis

Background. The role of RAD51 gene polymorphisms with the development of head and neck cancer (HNC) and esophageal cancer (EC) remains controversial. This meta-analysis was conducted to evaluate the correlation between the RAD51 polymorphisms and these two cancers quantitatively. Methods. Databases of PubMed, Web of Science, and Embase were used to search relevant papers prior to August 17, 2019. STATA 11.0 was performed to observe the correlation. Results. Ten relevant papers were enrolled in our analysis. Overall, a significant correlation was observed between the rs1801320 polymorphism and the increased risk of these two cancers (OR=1.32, 95%CI=1.03‐1.71 for C vs. G; OR=1.50, 95%CI=1.03‐2.19 for CG vs. GG; and OR=1.44, 95%CI=1.05‐1.99 for CC+CG vs. GG). In subgroup analyses, an increased risk was found for EC (OR=2.07, 95%CI=1.01‐4.25 for C vs. G; OR=2.08, 95%CI=1.17‐3.71 for CC vs. GG; and OR=1.78, 95%CI=1.00‐3.15 for CC vs. CG+GG), but not for HNC. Moreover, our analysis revealed that no statistical evidence of correlation was discovered between the polymorphism of rs1801321 and the increased risk of HNC. However, stratified analysis based on ethnicity suggested that rs1801321 polymorphism was related to the decreased risk of HNC among Caucasians (OR=0.82, 95%CI=0.72‐0.95 for T vs. G). Conclusions. rs1801320 polymorphism was strongly associated with the risk of these two associated cancers, especially with esophageal cancer. Moreover, our results revealed that rs1801321 polymorphism was correlated to the decreased risk of HNC among Caucasians.

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Genetic Association betweenNFKBIAandNFKB1Gene Polymorphisms and the Susceptibility to Head and Neck Cancer: A Meta-Analysis

Disease Markers ◽

10.1155/2019/6523837 ◽

2019 ◽

Vol 2019 ◽

pp. 1-10 ◽

Cited By ~ 2

Author(s):

Lin Li ◽

Zhong-Ti Zhang

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Web Of Science ◽

Meta Analysis ◽

Case Control ◽

Statistical Correlation ◽

Case Control Studies ◽

The Relationship

Background. The role of theNFKB1gene rs28362491 polymorphism andNFKBIAgene rs2233406 polymorphism in the development of head and neck cancer (HNC) remains controversial. This meta-analysis was performed to assess the relationship between the gene polymorphisms and HNC quantitatively.Methods. PubMed, Embase, Web of Science, WanFang Data, and China National Knowledge databases were used to search for eligible articles. The relationship was evaluated by STATA 11.0.Results. Eight eligible articles were included in our study. Nine case-control studies from the eight included articles were correlated with rs28362491 polymorphism. Four articles were related to rs2233406 polymorphism. Overall, a significant correlation was observed between the rs28362491 polymorphism and a decreased risk of HNCs (OR=0.76,95%CI=0.60‐0.97for DD vs. II;OR=0.80,95%CI=0.68‐0.95for DD vs. DI+II). In subgroup analyses, the rs28362491 polymorphism was associated with the risk of nasopharyngeal carcinoma (NC), but not with oral cancer (OC). In addition, no statistical correlation was found between the polymorphism of rs2233406 and HNCs.Conclusion. rs28362491 polymorphism was significantly associated with the risk of HNCs, especially with NC. Additionally, our results showed that no association was discovered between rs2233406 polymorphism and HNCs.

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The role of anti-EGFR agents in patients with locoregionally advanced head and neck cancer: a meta-analysis of randomized trials

Oncotarget ◽

10.18632/oncotarget.21987 ◽

2017 ◽

Vol 8 (60) ◽

pp. 102371-102380 ◽

Cited By ~ 3

Author(s):

Bum Jun Kim ◽

Jae Ho Jeong ◽

Hyeong Su Kim ◽

Jung Han Kim

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Randomized Trials ◽

Meta Analysis ◽

Advanced Head

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Circulating MicroRNAs as Prognostic Molecular Biomarkers in Human Head and Neck Cancer: A Systematic Review and Meta-Analysis

Disease Markers ◽

10.1155/2019/8632018 ◽

2019 ◽

Vol 2019 ◽

pp. 1-12 ◽

Cited By ~ 3

Author(s):

Shree Ram Lamichhane ◽

Thanuja Thachil ◽

Harriet Gee ◽

Natalie Milic

Keyword(s):

Systematic Review ◽

Overall Survival ◽

Head And Neck Cancer ◽

Head And Neck ◽

Cancer Patients ◽

Neck Cancer ◽

Meta Analysis ◽

Prognostic Role ◽

Circulating Micrornas

Background. Circulating microRNAs (miRNAs) are potential molecular biomarkers for cancer detection; however, little is known about their prognostic role in head and neck cancer. This current study is aimed at evaluating the role of novel miRNAs in the survival of head and neck cancer patients. Materials and Methods. We performed a systematic literature search using online databases for articles published between December 2006 and February 2019. A meta-analysis was conducted to assess the correlation between miRNA expressions and overall survival (OS) among the selected head and neck cancer studies. After multilevel screening by reviewers, meta-analysis was performed using hazard ratios (HR) and associated 95% confidence interval (CI) of survival to calculate a pooled effect size. Result. A total of 1577 patients across 13 studies were included in the literature review, with 18 miRNAs upregulated and 4 miRNAs downregulated predicting a poor overall survival. The forest plot generated using cumulated survival data resulted in a pooled HR value of 2.943 (95% CI: 2.394-3.618) indicating a strong association of dysregulated miRNA expression with a poor outcome. Only 2 miRNAs—low levels of miR-9 and high levels of miR-483-5p—were observed in two studies, both showing a significant association with overall cancer survival. Conclusion. To our knowledge, this is the first comprehensive systematic review and meta-analysis that examines the prognostic role of circulating miRNAs from blood in head and neck cancer patients. The combined effect estimates a HR across multiple studies and also supports the previous individual findings that an alteration in miRNA expression is highly associated with poor prognosis. This has the potential to use serum and/or plasma miRNAs as biomarkers and become novel tools for predicting the prognosis of head and neck cancer patients in the near future.

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miR-146a C/G polymorphism increased the risk of head and neck cancer, but overall cancer risk: an analysis of 89 studies

Bioscience Reports ◽

10.1042/bsr20171342 ◽

2018 ◽

Vol 38 (1) ◽

Author(s):

Dezhong Sun ◽

Xiaoyan Zhang ◽

Xiaolei Zhang

Keyword(s):

Head And Neck Cancer ◽

Cancer Risk ◽

Head And Neck ◽

Neck Cancer ◽

Large Scale ◽

Meta Analysis ◽

Cochrane Library ◽

Dominant Model ◽

Case Control Studies ◽

Stratified Analysis

Several studies have evaluated the association of miR-146a C/G with head and neck cancer (HNC) susceptibility, and overall cancer risk, but with inconclusive outcomes. To drive a more precise estimation, we carried out this meta-analysis. The literature was searched from MEDLINE (mainly PubMed), Embase, the Cochrane Library, and Google Scholar databases to identify eligible studies. A total of 89 studies were included. The results showed that miR-146a C/G was significantly associated with increased HNC risk in dominant model (I2 =15.6%, Pheterogeneity=0.282, odds ratio (OR) =1.088, 95% confidence interval (CI) =1.002–1.182, P=0.044). However, no cancer risk was detected under all genetic models. By further stratified analysis, we found that rs4919510 mutation contributed to the risk of HNC amongst Asians under homozygote model (I2 =0, Pheterogeneity=0.541, OR =1.189, 95% CI =1.025–1.378, P=0.022), and dominant model (I2 =0, Pheterogeneity=0.959, OR =1.155, 95% CI =1.016–1.312, P=0.028). Simultaneously, in the stratified analysis by source of controls, a significantly increased cancer risk amongst population-based studies was found under homozygote model, dominant model, recessive model, and allele comparison model. However, no significant association was found in the stratified analysis by ethnicity and source of control. The results indicated that miR-146a C/G polymorphism may contribute to the increased HNC susceptibility and could be a promising target to forecast cancer risk for clinical practice. However, no significant association was found in subgroup analysis by ethnicity and source of control. To further confirm these results, well-designed large-scale case–control studies are needed in the future.

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Role of chemotherapy in 5000 patients with head and neck cancer treated by curative surgery: A subgroup analysis of the meta-analysis of chemotherapy in head and neck cancer

Oral Oncology ◽

10.1016/j.oraloncology.2019.06.001 ◽

2019 ◽

Vol 95 ◽

pp. 106-114 ◽

Cited By ~ 10

Author(s):

Etienne Dauzier ◽

Benjamin Lacas ◽

Pierre Blanchard ◽

Quynh-Thu Le ◽

Christian Simon ◽

...

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Subgroup Analysis ◽

Meta Analysis ◽

Curative Surgery

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Key approaches to interpret the findings of a meta-analysis on role of chemotherapy in 5000 patients with head and neck cancer treated by curative surgery

Oral Oncology ◽

10.1016/j.oraloncology.2019.08.020 ◽

2019 ◽

Vol 98 ◽

pp. 174-175 ◽

Cited By ~ 1

Author(s):

Rama Jayaraj ◽

Madurantakam Royam Madhav ◽

Shanthi Sabarimurugan ◽

Chellan Kumarasamy ◽

Sameep S. Shetty ◽

...

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Meta Analysis ◽

Curative Surgery

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Role of c‐Met expression on prognosis of head and neck cancer: A literature review and meta‐analysis

Head & Neck ◽

10.1002/hed.25655 ◽

2019 ◽

Vol 41 (6) ◽

pp. 1999-2006 ◽

Cited By ~ 5

Author(s):

Lei Li ◽

Zhijun Sun ◽

Xin Huang ◽

Xiao Li ◽

Lihua Sun ◽

...

Keyword(s):

Head And Neck Cancer ◽

Literature Review ◽

Head And Neck ◽

Neck Cancer ◽

Meta Analysis

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Changes in T lymphocyte subsets in different tumors before and after radiotherapy: A meta-analysis.

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.15_suppl.2525 ◽

2021 ◽

Vol 39 (15_suppl) ◽

pp. 2525-2525

Author(s):

Xiaoxia Zhu ◽

Qin Wang ◽

Shangbiao Li ◽

Simiao Qiao ◽

Zhihao Zheng ◽

...

Keyword(s):

Esophageal Cancer ◽

Head And Neck Cancer ◽

T Lymphocytes ◽

Liver Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Meta Analysis ◽

Tumor Patients ◽

Cd8 T Lymphocytes ◽

Before And After

2525 Background: Radiation therapy (RT) induces an immune response, but the relationship of this response with tumor type is not fully understood. Methods: We searched English-language electronic databases including PubMed, EMBASE, and the Cochrane Library to collect studies about the changes in CD3+ T lymphocytes, CD4+ T lymphocytes, and CD8+ T lymphocytes before and after radiotherapy in tumor patients from January 2015 to December 2019. The quality of the included literature was evaluated using the NOS scale provided by the Cochrane Collaboration, and statistical software RevMan 5.4 was used to analyze the included literature. p < 0.05 was considered to indicate statistical significance. Results: A total of 17 studies in 15 articles involving 1735 tumor patients were included. All data were collected within 1 month before or after radiotherapy. Meta-analysis showed that numbers of CD3+ T lymphocytes were significantly reduced after radiotherapy compared with before treatment (standard mean difference [SMD]: -0.76; 95% CI [-1.46, -0.06]; p = 0.03), as were those of CD4+ T lymphocytes (SMD: -0.50; 95% CI: [-0.88, -0.12]; p = 0.01), but there was no statistically significant difference for CD8+ T lymphocytes (SMD: 0.19; 95% CI: [-0.23, 0.62]; p = 0.38). Subgroup analysis showed significant decreases in CD3+ T lymphocytes in liver cancer,esophageal cancer, head and neck cancer, pancreatic cancer and breast cancer after radiotherapy. Numbers of CD4+T lymphocytes increased after radiotherapy in breast cancer,and a decrease was observed in liver cancer, esophageal cancer, colorectal cancer, and head and neck cancer. CD8+ T lymphocyte numbers also increased compared with before radiotherapy in esophageal cancer, lung cancer, and colorectal cancer. But a decrease in liver cancer and head and neck cancer. Conclusions: Numbers of CD3+ and CD4+ T lymphocytes decreased after radiotherapy, whereas CD8+ T lymphocytes showed no significant change. Within 1 month of radiotherapy, the tumor microenvironment showed an immunosuppressive state. The degree of immune response induced by radiotherapy differed between tumor types.

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