Abstract
Stereotactic neurosurgery requires a careful planning of cannulae paths to spare eloquent areas of the brain that, if damaged, will result in loss of essential neurological function such as sensory processing, linguistic ability, vision, or motor function. We present an approach based on modelling, simulation, and optimization to set up a computational assistant tool. Thereby, we focus on the modeling of the brain topology, where we construct ellipsoidal approximations of voxel clouds based on processed MRI data. The outcome is integrated in a path-planning problem either via constraints or by penalization terms in the objective function. The surgical planning problem with obstacle avoidance is solved for different types of stereotactic cannulae using numerical simulations. We illustrate our method with a case study using real MRI data.
Suiting Dynamic Models of Fixed-Bed Catalytic Reactors for Computer-Based Applications
