Inhibition of Dermal Fibrosis by Interferons

2019 ◽  
pp. 209-226
Author(s):  
Brian Berman ◽  
Matthew R. Duncan
Keyword(s):  
Dermal Fibrosis

Photosensitization Induced by Heterophyllaea pustulata in Goats: Sequential Development of Skin Lesions

2021 ◽  
Vol 58 (3) ◽  
pp. 568-573
Author(s):  
Juan F. Micheloud ◽  
Lluís Luján ◽  
Luis A. Colque-Caro ◽  
Susana C. Núñez-Montoya ◽  
Claudio G. Barbeito ◽  
...  
Keyword(s):  
Cell Death ◽  
Oral Dose ◽  
Skin Lesions ◽  
Crust Formation ◽  
Cutaneous Lesions ◽  
Protein Ratio ◽  
Dermal Fibrosis ◽  
Sequential Development ◽  
Treatment Changes ◽  
Skin Biopsies

Five adult Saanen goats received a single oral dose of Heterophyllaea pustulata containing 42.25 μg/kg rubiadin (anthraquinone) and 3 adult goats were untreated controls. All goats were exposed to sunlight and sequential ear skin biopsies were collected before treatment and at 32 hours, 3 days, 8 days, and 15 days after treatment. Changes at 32 hours after dosing included epidermal spongiosis, single cell death and acantholysis, an increased BAX/BCL-2 protein ratio, and dermal edema. Lesions at day 3 included epidermal and adnexal necrosis, crust formation, and acanthosis. Acanthosis, hyperkeratosis, and dermal fibrosis and neovascularization were present at day 15. The pro-apoptotic (BAX)/anti-apoptotic (BCL-2) protein ratio increased at 32 hours, whereas epidermal and dermal PCNA immunolabeling increased between days 8 and 15 after treatment. The cutaneous lesions were consistent with sunlight-induced damage, and the occurrence in treated but not control goats indicates photosensitization.

Therapeutic effect of cyclin‐dependent kinase 4/6 inhibitor on dermal fibrosis in murine models of systemic sclerosis

2021 ◽  
Author(s):  
Akio Yamamoto ◽  
Tetsuya Saito ◽  
Tadashi Hosoya ◽  
Kimito Kawahata ◽  
Yoshihide Asano ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Therapeutic Effect ◽  
Cyclin Dependent Kinase ◽  
Murine Models ◽  
Dermal Fibrosis

scholarly journals Intervention of Inflammatory Monocyte Activity Limits Dermal Fibrosis

2019 ◽  
Vol 139 (10) ◽  
pp. 2144-2153 ◽  
Author(s):  
Jessica Haub ◽  
Nadine Roehrig ◽  
Pavel Uhrin ◽  
Gernot Schabbauer ◽  
Dirk Eulberg ◽  
...  
Keyword(s):  
Inflammatory Monocyte ◽  
Dermal Fibrosis

Dermal fibrosis related to combination chemotherapy with carboplatin and gemcitabine

2011 ◽  
Vol 21 (6) ◽  
pp. 999-1001
Author(s):  
Amiko Hashimoto ◽  
Nao Yamamoto ◽  
Yasuki Hata ◽  
Miki Takahashi ◽  
Reiko Shimokawa
Keyword(s):  
Combination Chemotherapy ◽  
Dermal Fibrosis

scholarly journals Nanoparticle Albumin-Bound Paclitaxel- and/or Gemcitabine-Induced Scleroderma Accompanied by Acanthosis Nigricans-Like Skin Changes

2019 ◽  
Vol 11 (3) ◽  
pp. 273-277 ◽  
Author(s):  
Sei-ichiro Motegi ◽  
Mai Ishikawa ◽  
Akiko Sekiguchi ◽  
Osamu Ishikawa
Keyword(s):  
Acanthosis Nigricans ◽  
Basal Layer ◽  
Accurate Diagnosis ◽  
Skin Changes ◽  
Hyperkeratotic Lesion ◽  
Dermal Fibrosis ◽  
First Case ◽  
Skin Sclerosis ◽  
Japanese Male ◽  
Old Japanese

We herein present the first case of nanoparticle albumin-bound paclitaxel (nab-paclitaxel)- and/or gemcitabine-induced scleroderma accompanied by acanthosis nigricans-like skin changes in a 54-year-old Japanese male. He was diagnosed with pancreatic cancer and received 17 courses of nab-paclitaxel and gemcitabine chemotherapy. Edema and skin sclerosis in his legs appeared after the first and third course, respectively. Histological examination of the hyperkeratotic lesion of the ankle revealed hyperkeratosis, acanthosis, papillomatosis, increased number of melanocytes in the basal layer, and dermal fibrosis. Awareness of the clinical characteristics of nab-paclitaxel- and/or gemcitabine-induced scleroderma accompanied by acanthosis nigricans-like skin changes is important for dermatologists to establish an accurate diagnosis.

scholarly journals Formyl Peptide Receptor 2 Activation Ameliorates Dermal Fibrosis and Inflammation in Bleomycin-Induced Scleroderma

2019 ◽  
Vol 10 ◽  
Author(s):  
Gyu Tae Park ◽  
Yang Woo Kwon ◽  
Tae Wook Lee ◽  
Seong Gyu Kwon ◽  
Hyun-Chang Ko ◽  
...  
Keyword(s):  
Formyl Peptide Receptor ◽  
Peptide Receptor ◽  
Dermal Fibrosis ◽  
Formyl Peptide
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