Human immunogenetic variation in the form of HLA and KIR types has been shown to be strongly associated with a multitude of immune-related phenotypes. We present MiDAS, an R package enabling statistical association analysis and using immunogenetic data transformation functions for HLA amino acid fine mapping, analysis of HLA evolutionary divergence as well as HLA-KIR interactions. MiDAS closes the gap between inference of immunogenetic variation and its efficient utilization to make meaningful discoveries.
In this work we propose a model to analyze the interaction of a two-level atom (TLA) placed in a cross cavity configuration interacting with two electromagnetic fields injected within the cavity. A canonical transformation for field operators is proposed to obtain effective Hamiltonian such as that of Jaynes-Cummings and we calculate the wave function via time-evolution operator. We present results for the atomic inversion for a state in the weak intensity regime.
Canonical transformation path to gauge theories of gravity
