Inhalation Risk Assessment at the Environmental Protection Agency

Author(s):  
John Whalan ◽  
Gary Foureman ◽  
John Vandenberg
2006 ◽  
Vol 25 (1) ◽  
pp. 19-21 ◽  
Author(s):  
K A Mundt

The US Environmental Protection Agency (EPA) recently issued a Staff Paper that articulates current risk assessment practices. In section 4.1.3, EPA states,“...effects that appear to be adaptive, non–adverse, or beneficial may not be mentioned.” This statement may be perceived as precluding risk assessments based on non–default risk models, including the hormetic–or biphasicdose–response model. This commentary examines several potential interpretations of this statement and the anticipated impact of ignoring hormesis, if present, in light of necessary conservatism for protecting human and environmental health, and the potential for employing alternative risk assessment approaches.


2020 ◽  
Vol 9 (1) ◽  
pp. 1
Author(s):  
Rose Ngozi Asomugha ◽  
Chijoke Emmanuel Igwe ◽  
Peace Ukamaka Nome ◽  
Onyinye Mary Uchendu ◽  
Nwamkwere Godson

Food Safety is of growing concern globally, and more so considering the relatively high proportion of soft drinks in the beverage market worldwide, and its rate of consumption especially amongst the youths. It is essential to evaluate the levels of toxic metals and Polycyclic Aromatic Hydrocarbons (PAHs) residues of which when present in soft drinks above the permissible limits could pose serious public health risk. The aim of this present study was to assess the levels of heavy metals (Pb, Hg, Cd ,As) and Polycyclic aromatic Hydrocarbons(PAHs) in 16 commercial soft drinks marketed in Awka, using Atomic Absorption Spectroscopy(AAS) and Flame Ionization detector (GC-FID), respectively. The carcinogenic and non-carcinogenic risk assessment were performed using the method established by United State Environmental Protection agency(USEPA).The data obtained were compared with the permissible limit set for drinking water by United State Environmental Protection Agency(USEPA),World Health Organization (WHO),Standard Organization of Nigeria(SON) and Federal Environmental Protection Agency(FEPA). The highest mean level of 0.6116 mg/l is related to Pb and the lowest of 0.0028mg/l related to Hg. The mean levels of the metals increased in this order: Hg<As<Cd<Pb. For the PAHs, using Benzo(a)pyrene as the benchmark for other PAHs congeners because of its strong carcinogenic potency, is not detected in this study, and thus pose no health risk. The target hazard quotient (THQ) of Hg in the studied samples is less than 1. Pb levels in75% the studied samples had THQ>1, and thus, pose a health risk. The hazard index, calculated as the combined risk of heavy metal toxicity is greater than unity (HI>1).The incremental lifetime cancer risk (ILCR) values estimated for Pb, As and Cd in the sample were 6.25%,31.25% and 25% ,respectively, representing higher than acceptable risk value of (10-6 -10-4) . The results raise a concern for the public exposed with respect to As and Cd carcinogenic risk values.  


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