Abstract
Objectives
Dietary calcium and magnesium have been shown to be beneficial for bone health primarily in non-Hispanic white populations. There are no studies of calcium and magnesium intake among Hispanics of Caribbean origin. A calcium to magnesium ratio (Ca: Mg) may be important due to their competitive nature during absorption. This study examined associations between dietary calcium and magnesium and osteoporosis, accounting for calcium to magnesium ratio among Puerto Rican adults
Methods
Data from the Boston Puerto Rican Osteoporosis Study were used. Puerto Ricans aged 47–79 y with complete data on bone and diet were included (n = 955). Bone measures were assessed using dual-energy X-ray absorptiometry. A food frequency questionnaire adapted for this population was used. Dietary calcium and magnesium were energy adjusted using the residual method. Tertiles of Ca : Mg were calculate. Multivariable logistic regressions modeled associations between calcium, magnesium and tertiles of Ca : Mg. Model 1 included Ca : Mg tertiles and dietary magnesium; Model 2 Ca : Mg tertiles and dietary calcium; Model 3 Ca : Mg tertiles and dietary calcium and magnesium. All models were adjusted for age, estrogenic status (male, non-menopausal or taking estrogen, postmenopausal not taking estrogen), height, BMI, calcium (0, 0–300 mg, ≥300 mg) and magnesium (0, 0–100 mg) supplement use, serum vitamin D, alcohol use, smoking status, and bone medication use.
Results
Mean age was 59.9 y ± 7.6 and 71.3% were female. In model 1, the highest tertile of Ca : Mg was associated with higher likelihood (OR: 1.3; 95%CI: 0.77, 2.4) and the middle tertile with lower likelihood (OR: 0.51; 95%CI: 0.26,0.99) of osteoporosis compared with the lowest Ca: Mg tertile. Dietary magnesium was also associated with lower odds of osteoporosis (OR: 0.99; 95%CI: 0.98, 0.99). In model 2, dietary calcium (OR: 0.99, 95%CI: 0.99, 1.0) was associated with lower of odds osteoporosis, but Ca: Mg was not. In model 3, dietary calcium and magnesium and tertiles of Ca : Mg were not associated with osteoporosis.
Conclusions
Dietary calcium and magnesium are important nutrients for bone health in Puerto Rican older adults. The Ca : Mg ratio appears optimal within a range of 2.6–3.1 suggesting that a balance of these two nutrients is most important.
Funding Sources
National Institutes of Health P01 AG023394, P50 HL105185, R01 AG027087 K01 AR067894