Products and their associated material, capital, and information are critical flows within supply chains. Supply chain management needs to facilitate product portfolio management. Some example activities include material sourcing, product design and manufacture, product delivery and transportation, product usage, and service. Closing the supply-chain loop, especially for sustainable supply chains, include end-of-life disposal and repurposing activities. Sustainable supply chain development typically focuses on three major dimensions of organizational competitiveness, economic, social, and environmental. Organizations make product deletion continuously. These decisions can profoundly contribute to sustainability. Alternatively, sustainability performance of various supply chain process and product or material flows may also be strategic product deletion reasons. This chapter will review the integration of product deletion with sustainable supply chain management. It will entail the impact of product deletion on sustainable supply chains.