scholarly journals Effect of Maternal Betamethasone, Thyrotropin Releasing Hormone and Betamethasone plus Thyrotropin Releasing Hormone Therapy on Mouse Fetal Lung Surfactant Protein A, B and C Expression. † 1455

1997 ◽  
Vol 41 ◽  
pp. 245-245
Author(s):  
Mohammed Ansari ◽  
Uday P. Devaskar ◽  
Daphne E. deMello
Keyword(s):  
Hormone Therapy ◽  
Lung Surfactant ◽  
Protein A ◽  
Fetal Lung ◽  
Surfactant Protein ◽  
Thyrotropin Releasing Hormone ◽  
Surfactant Protein A ◽  
Releasing Hormone ◽  
Lung Surfactant Protein

scholarly journals Cutting Edge: The Immunostimulatory Activity of the Lung Surfactant Protein-A Involves Toll-Like Receptor 4

2002 ◽  
Vol 168 (12) ◽  
pp. 5989-5992 ◽  
Author(s):  
Loïc Guillot ◽  
Viviane Balloy ◽  
Francis X. McCormack ◽  
Douglas T. Golenbock ◽  
Michel Chignard ◽  
...  
Keyword(s):  
Lung Surfactant ◽  
Protein A ◽  
Surfactant Protein ◽  
Cutting Edge ◽  
Surfactant Protein A ◽  
Toll Like Receptor ◽  
Immunostimulatory Activity ◽  
Toll Like Receptor 4 ◽  
Lung Surfactant Protein

Clearance of intra-amniotic lung surfactant: uptake and utilization by the fetal rabbit lung

1997 ◽  
Vol 273 (1) ◽  
pp. L55-L63 ◽  
Author(s):  
M. Hallman ◽  
U. Lappalainen ◽  
K. Bry
Keyword(s):  
Amniotic Fluid ◽  
Lung Surfactant ◽  
Protein A ◽  
Alveolar Epithelium ◽  
Fetal Lung ◽  
Surfactant Protein ◽  
Lung Compliance ◽  
Rabbit Lung ◽  
Lower Lung ◽  
Lung Surfactant Protein

To investigate the metabolism of intra-amniotic surfactant, surfactant containing double-labeled dipalmitoylphosphatidylcholine (DPPC) was injected in amniotic fluid on days 23-27 of gestation. Within 44 h, DPPC was distributed to the gastrointestinal tract (45.9%), fetal membranes and placenta (8.2%), fetal lung (6.6%), and liver (1.9%). DPPC uptake was higher in the upper than in the lower lung lobes. The mixture of phosphatidylglycerol and DPPC increased the uptake of DPPC that was not saturable (range 15-60 mg phospholipid). There was no detectable metabolism of DPPC taken up by the fetal lung. Surfactant protein A, originating from intra-amniotic heterplogous surfactant, was detected immunohistochemically in alveolar epithelium. Intra-amniotic surfactants did not affect the expression of surfactant protein mRNAs. Intra-amniotic surfactant (1,500-2,000 mg/kg on day 25.3) improved lung compliance of ventilated 27.0-day premature rabbits less than intratracheal surfactant at birth (75-100 mg/kg). Reutilization by the alveolar epithelium of surfactant secreted to future airspaces, airways, and amniotic fluid may be a mechanism that increases intracellular surfactant pool before birth.

Expression and Localization of Lung Surfactant Protein A in Human Tissues

2003 ◽  
Vol 29 (5) ◽  
pp. 591-597 ◽  
Author(s):  
Jens Madsen ◽  
Ida Tornøe ◽  
Ole Nielsen ◽  
Claus Koch ◽  
Wolfram Steinhilber ◽  
...  
Keyword(s):  
Lung Surfactant ◽  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Human Tissues ◽  
Lung Surfactant Protein

scholarly journals Elucidation of Lipid Binding Sites on Lung Surfactant Protein A Using X-ray Crystallography, Mutagenesis, and Molecular Dynamics Simulations

Biochemistry ◽  
2016 ◽  
Vol 55 (26) ◽  
pp. 3692-3701 ◽  
Author(s):  
Boon Chong Goh ◽  
Huixing Wu ◽  
Michael J. Rynkiewicz ◽  
Klaus Schulten ◽  
Barbara A. Seaton ◽  
...  
Keyword(s):  
Binding Sites ◽  
Lung Surfactant ◽  
Protein A ◽  
Surfactant Protein ◽  
Lipid Binding ◽  
Surfactant Protein A ◽  
X Ray ◽  
X Ray Crystallography ◽  
Lung Surfactant Protein ◽  
Dynamics Simulations

scholarly journals Delayed alveolar clearance of nanoparticles through control of coating composition and interaction with lung surfactant protein A

2021 ◽  
pp. 112551
Author(s):  
Susana Carregal-Romero ◽  
Hugo Groult ◽  
Olga Cañadas ◽  
Noelia A-Gonzalez ◽  
Ana Victoria Lechuga-Vieco ◽  
...  
Keyword(s):  
Lung Surfactant ◽  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Coating Composition ◽  
Lung Surfactant Protein
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