scholarly journals Total Body Bone Mineral Content (TBBMC) in Preterm Infants at Birth Using Dual Energy X-ray Absorptiometry (DEXA) 1530

1998 ◽  
Vol 43 ◽  
pp. 261-261
Author(s):  
Renu Jain ◽  
Robert H Wagner ◽  
Thomas F Myers
2019 ◽  
Vol 316 (1) ◽  
pp. R59-R67
Author(s):  
Tamara Hew-Butler ◽  
Kailyn Angelakos ◽  
Joshua Szczepanski

The purpose of this study was to assess relationships between plasma sodium concentration ([Na+]) and bone mineral content (BMC) after an acute sodium load plus treadmill walking and then quantify the amount of sodium the dual energy X-ray absorptiometry (DXA) scan could detect. The primary study was a single-blind randomized control crossover trial under two conditions: ingestion of six flour tablets (placebo trial) or six 1-g NaCl tablets (salt intervention trial). The tablets were ingested after baseline blood and urine collection followed immediately by the DXA scan. After 60 min of rest, a 45-min treadmill walk was conducted. Immediately postexercise, blood and urine were collected and the DXA scan was repeated. Main outcomes included changes (∆: post minus pre) in plasma [Na+] and BMC. Additionally, six 1-g NaCl tablets were superimposed over a DXA spine phantom for separate quantification of sodium as BMC. Fourteen subjects completed the primary study. Two-way repeated measures ANOVA tests revealed significant interaction ( F = 13.06; P = 0.0007), condition ( F = 21.88; P < 0.001), and time ( F = 6.51; P = 0.014) effects in plasma [Na+]. A significant condition ( F = 6.46; P = 0.014) effect was also noted in urine [Na+]. Total body BMC∆ was negatively correlated with plasma [Na+]∆ ( r = −0.43; P = 0.02) and urine [Na+]∆ ( r = −0.47; P = 0.01). Total body BMC∆ in the salt intervention trial [−5.5 (27) g] closely approximated the amount of NaCl ingested and subsequently absorbed into the bloodstream. The DXA scan quantified 67% of NaCl tablets as BMC in spine phantom analyses. Total body BMC∆ was negatively related to plasma and urine [Na+]∆ after treadmill walking. Reductions in total body BMC closely approximated the amount of NaCl ingested (~6 g). The DXA scan quantified NaCl as BMC.


1992 ◽  
Vol 24 (Supplement) ◽  
pp. S11 ◽  
Author(s):  
P. C. Fehling ◽  
R. J. Stillman ◽  
K. A. Boileau ◽  
M. H. Slaughter ◽  
J. L. Clasey ◽  
...  

PEDIATRICS ◽  
1992 ◽  
Vol 90 (5) ◽  
pp. 767-770
Author(s):  
Pankaja S. Venkataraman ◽  
B. Wally Ahluwalia

Measurement of total body bone mineral content and body composition has not previously been convenient in the newborn. X-ray densitometry, otherwise known as dual-energy x-ray absorptiometry (DEXA), has been used in adults to assess with accuracy and precision the total body mineral content, lean mass, and fat. Body composition measurements were determined in vivo by DEXA in term newborns, and they were compared with values reported by chemical analysis of the cadaver, with skin-fold thickness measurements, and with bone mineral content measured by single photon absorptiometry. The intermeasurement coefficient of variation was ≤2.5% for bone mineral content, and ≤1% for fat and lean mass. The values for bone mineral content, fat, and lean mass fall within the ranges expected based on the reported values measured by chemical analysis of the infant cadaver. Triceps and quadriceps skin-fold measurements were best correlated with total body fat as measured by DEXA. The bone mineral content of the distal third radius site as measured by single photon absorptiometry in newborns showed significant correlation with total body bone mineral content. DEXA provides a reproducible and convenient method for the determination of body composition in newborns.


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