Potential of Near-Infrared Chemical Imaging as Process Analytical Technology Tool for Continuous Freeze-Drying

2018 ◽  
Vol 90 (7) ◽  
pp. 4354-4362 ◽  
Author(s):  
Davinia Brouckaert ◽  
Laurens De Meyer ◽  
Brecht Vanbillemont ◽  
Pieter-Jan Van Bockstal ◽  
Joris Lammens ◽  
...  
Keyword(s):  
Freeze Drying ◽  
Near Infrared ◽  
Process Analytical Technology ◽  
Chemical Imaging ◽  
Technology Tool ◽  
Analytical Technology

scholarly journals Process analytical technology tools for process control of roller compaction in solid pharmaceuticals manufacturing

2020 ◽  
Vol 70 (4) ◽  
pp. 443-463 ◽  
Author(s):  
Aleša Dular Vovko ◽  
Franc Vrečer
Keyword(s):  
Infrared Spectroscopy ◽  
Process Control ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Process Analytical Technology ◽  
Imaging Techniques ◽  
Thermal Effusivity ◽  
Chemical Imaging ◽  
Roller Compaction ◽  
Analytical Technology

AbstractThis article presents an overview of using process analytical technology in monitoring the roller compaction process. In the past two decades, near-infrared spectroscopy, near-infrared spectroscopy coupled with chemical imaging, microwave resonance technology, thermal effusivity and various particle imaging techniques have been used for developing at-, off-, on- and in-line models for predicting critical quality attributes of ribbons and subsequent granules and tablets. The common goal of all these methods is improved process understanding and process control, and thus improved production of high-quality products. This article reviews the work of several researchers in this field, comparing and critically evaluating their achievements.

Active content determination of pharmaceutical tablets using near infrared spectroscopy as Process Analytical Technology tool

Talanta ◽  
2015 ◽  
Vol 144 ◽  
pp. 1352-1359 ◽  
Author(s):  
Pierre-François Chavez ◽  
Pierre-Yves Sacré ◽  
Charlotte De Bleye ◽  
Lauranne Netchacovitch ◽  
Jérôme Mantanus ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Process Analytical Technology ◽  
Pharmaceutical Tablets ◽  
Content Determination ◽  
Technology Tool ◽  
Analytical Technology ◽  
Active Content
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