Real Patient and its Virtual Twin: Application of Quantitative Systems Toxicology Modelling in the Cardiac Safety Assessment of Citalopram

The AAPS Journal ◽

10.1208/s12248-017-0155-8 ◽

2017 ◽

Vol 20 (1) ◽

Author(s):

Nikunjkumar Patel ◽

Barbara Wiśniowska ◽

Masoud Jamei ◽

Sebastian Polak

Keyword(s):

Safety Assessment ◽

Cardiac Safety ◽

Real Patient ◽

Systems Toxicology ◽

Quantitative Systems Toxicology

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Physiologically based pharmacokinetic-quantitative systems toxicology and safety (PBPK-QSTS) modeling approach applied to predict the variability of amitriptyline pharmacokinetics and cardiac safety in populations and in individuals

Journal of Pharmacokinetics and Pharmacodynamics ◽

10.1007/s10928-018-9597-6 ◽

2018 ◽

Vol 45 (5) ◽

pp. 663-677 ◽

Author(s):

Zofia Tylutki ◽

Aleksander Mendyk ◽

Sebastian Polak

Keyword(s):

Cardiac Safety ◽

Systems Toxicology ◽

Modeling Approach ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Quantitative Systems Toxicology

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P86.12 Cardiac Safety Assessment of Lazertinib in Patients with EGFR Mutation-Positive Advanced Non-Small Cell Lung Cancer

Journal of Thoracic Oncology ◽

10.1016/j.jtho.2021.01.1241 ◽

2021 ◽

Vol 16 (3) ◽

pp. S677-S678

Author(s):

N. Haddish-Berhane ◽

B.C. Cho ◽

M. Ahn ◽

J. Han ◽

S. Kim ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Safety Assessment ◽

Egfr Mutation ◽

Cardiac Safety ◽

Small Cell Lung

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Cardiac safety assessment of drugs using three-dimensional heart simulator

Journal of Pharmacological and Toxicological Methods ◽

10.1016/j.vascn.2016.02.054 ◽

2016 ◽

Vol 81 ◽

pp. 351

Author(s):

Jun-ichi Okada ◽

Takashi Yoshinaga ◽

Junko Kurokawa ◽

Takumi Washio ◽

Tetsushi Furukawa ◽

...

Keyword(s):

Safety Assessment ◽

Three Dimensional ◽

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Quantitative systems toxicology (QST) reproduces species differences in PF‐04895162 liver safety due to combined mitochondrial and bile acid toxicity

Pharmacology Research & Perspectives ◽

10.1002/prp2.523 ◽

2019 ◽

Vol 7 (6) ◽

Author(s):

Grant Generaux ◽

Vinal V. Lakhani ◽

Yuching Yang ◽

Sashi Nadanaciva ◽

Luping Qiu ◽

...

Keyword(s):

Bile Acid ◽

Species Differences ◽

Systems Toxicology ◽

Liver Safety ◽

Quantitative Systems Toxicology ◽

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Multi-parametric assessment of cardiomyocyte excitation-contraction coupling using impedance and field potential recording: A tool for cardiac safety assessment

Journal of Pharmacological and Toxicological Methods ◽

10.1016/j.vascn.2016.06.004 ◽

2016 ◽

Vol 81 ◽

pp. 201-216 ◽

Author(s):

Xiaoyu Zhang ◽

Liang Guo ◽

Haoyu Zeng ◽

Stephen L. White ◽

Michael Furniss ◽

...

Keyword(s):

Safety Assessment ◽

Field Potential ◽

Cardiac Safety ◽

Excitation Contraction Coupling ◽

Contraction Coupling ◽

Potential Recording ◽

Field Potential Recording

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Isolated rat heart assay: Validation and potential uses in cardiac safety assessment

Journal of Pharmacological and Toxicological Methods ◽

10.1016/j.vascn.2011.03.044 ◽

2011 ◽

Vol 64 (1) ◽

pp. e11-e12

Author(s):

BaoXi Gao ◽

Yusheng Qu ◽

Mei Fang ◽

Jiansong Xie ◽

Gloria Juan ◽

...

Keyword(s):

Rat Heart ◽

Safety Assessment ◽

Isolated Rat Heart ◽

Cardiac Safety ◽

Assay Validation ◽

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The newcomer is getting up and running: Human iPS cell-derived cardiomyocyte implementation in multiple cardiac safety assessment assays

Journal of Pharmacological and Toxicological Methods ◽

10.1016/j.vascn.2015.08.131 ◽

2015 ◽

Vol 75 ◽

pp. 197 ◽

Author(s):

Ralf Kettenhofen ◽

Anika Duenbostell ◽

Bettina Bertram ◽

Matthias Gossmann ◽

Gesa Rascher-Eggstein

Keyword(s):

Safety Assessment ◽

Cardiac Safety ◽

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Quantitative systems toxicology

Current Opinion in Toxicology ◽

10.1016/j.cotox.2017.07.003 ◽

2017 ◽

Vol 4 ◽

pp. 79-87 ◽

Author(s):

Peter Bloomingdale ◽

Conrad Housand ◽

Joshua F. Apgar ◽

Bjorn L. Millard ◽

Donald E. Mager ◽

...

Keyword(s):

Systems Toxicology ◽

Quantitative Systems Toxicology

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Quantitative Systems Toxicology Analysis ofIn VitroMechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury

Toxicological Sciences ◽

10.1093/toxsci/kfy253 ◽

2018 ◽

Vol 167 (2) ◽

pp. 458-467 ◽

Author(s):

Diane M Longo ◽

Jeffrey L Woodhead ◽

Paul Walker ◽

Krisztina Herédi-Szabó ◽

Károly Mogyorósi ◽

...

Keyword(s):

Bile Acid ◽

Liver Injury ◽

Mitochondrial Dysfunction ◽

Systems Toxicology ◽

Acid Accumulation ◽

Quantitative Systems Toxicology

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Comprehensive in vitro cardiac safety assessment using human stem cell technology (CSAHi–The second stage) –Ca2+ transient platform

Journal of Pharmacological and Toxicological Methods ◽

10.1016/j.vascn.2019.05.163 ◽

2019 ◽

Vol 99 ◽

pp. 106595

Author(s):

Kiyoshi Takasuna ◽

Yayoi Honda ◽

Mahoko Asayama ◽

Hideaki Mitsui ◽

Chifumi Nagano ◽

...

Keyword(s):

Stem Cell ◽

Safety Assessment ◽

Human Stem Cell ◽

Cardiac Safety ◽

Stem Cell Technology ◽

Cell Technology ◽

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