Formulation Optimization of Selective Laser Sintering 3D-Printed Tablets of Clindamycin Palmitate Hydrochloride by Response Surface Methodology

2020 ◽  
Vol 21 (6) ◽  
Author(s):  
Eman M. Mohamed ◽  
Sogra F. Barakh Ali ◽  
Ziyaur Rahman ◽  
Sathish Dharani ◽  
Tanil Ozkan ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Selective Laser Sintering ◽  
Laser Sintering ◽  
Formulation Optimization ◽  
3D Printed

Optimization of Process Parameters Applied to a Prototype Selective Laser Sintering System

2017 ◽  
Author(s):  
Abass Enzi ◽  
James A. Mynderse
Keyword(s):  
Mathematical Model ◽  
Surface Roughness ◽  
Response Surface Methodology ◽  
Response Surface ◽  
Crack Width ◽  
Selective Laser Sintering ◽  
Optimal Solution ◽  
Laser Sintering ◽  
Powder Layer ◽  
Layer By Layer

Selective laser sintering is an additive manufacturing technique that uses a high power laser to sinter or melt powder layer by layer to build 3D shapes. This paper focuses on creating a mathematical model of the crack width and surface roughness that occur during the selective laser sintering process. Response surface methodology is used to build and determine a mathematical model. Five variables at five levels are selected: forward step, side step, speed, platform temperature and layer depth. Based on response surface methodology, 32 experiments are used to determine the mathematical model of two selective laser sintering defects: crack width and surface roughness. Next, a genetic algorithm is used to determine the optimal solution to minimize crack width and surface roughness of the part. Results show that the five selected parameters have an effect on the target defects as confirmed by the resulting main effects plots, interaction plots, and contour plots. An optimal set of parameters is determined for future use.

Formulation Optimization of Estradiol Microemulsion Using Response Surface Methodology

2011 ◽  
Vol 100 (10) ◽  
pp. 4383-4389 ◽  
Author(s):  
Yi-Hung Tsai ◽  
Li-Tse Fu ◽  
Chi-Te Huang ◽  
Jui-Sheng Chang ◽  
Yaw-Bin Huang ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Formulation Optimization

scholarly journals Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron

Pharmaceutics ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 110 ◽  
Author(s):  
Nour Allahham ◽  
Fabrizio Fina ◽  
Carmen Marcuta ◽  
Lilia Kraschew ◽  
Wolfgang Mohr ◽  
...  
Keyword(s):  
3D Printing ◽  
Selective Laser Sintering ◽  
Laser Sintering ◽  
Manufacturing Technology ◽  
Commercial Product ◽  
Cyclodextrin Complexes ◽  
Orally Disintegrating Tablet ◽  
3D Printed ◽  
Added Benefit ◽  
Different Levels

The aim of this work was to explore the feasibility of using selective laser sintering (SLS) 3D printing (3DP) to fabricate orodispersable printlets (ODPs) containing ondansetron. Ondansetron was first incorporated into drug-cyclodextrin complexes and then combined with the filler mannitol. Two 3D printed formulations with different levels of mannitol were prepared and tested, and a commercial ondansetron orally disintegrating tablet (ODT) product (Vonau® Flash) was also investigated for comparison. Both 3D printed formulations disintegrated at ~15 s and released more than 90% of the drug within 5 min independent of the mannitol content; these results were comparable to those obtained with the commercial product. This work demonstrates the potential of SLS 3DP to fabricate orodispersible printlets with characteristics similar to a commercial ODT, but with the added benefit of using a manufacturing technology able to prepare medicines individualized to the patient.

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