Optimization and Evaluation of the Thermosensitive In Situ and Adhesive Gel for Rectal Delivery of Budesonide

2020 ◽  
Vol 21 (3) ◽  
Author(s):  
Lin Chen ◽  
Xue Han ◽  
Xiaohong Xu ◽  
Quan Zhang ◽  
Yingchun Zeng ◽  
...  
Keyword(s):  
Rectal Delivery

Thermosensitive In Situ Gel Based on Solid Dispersion for Rectal Delivery of Ibuprofen

2017 ◽  
Vol 19 (1) ◽  
pp. 338-347 ◽  
Author(s):  
Yangdan Liu ◽  
Xin Wang ◽  
Youping Liu ◽  
Xin Di
Keyword(s):  
Solid Dispersion ◽  
In Situ Gel ◽  
Rectal Delivery

Expert design and desirability function approach for the development of diazepam thermally sensitive rectal gel

2020 ◽  
Vol 11 (1) ◽  
pp. 813-830 ◽  
Author(s):  
Seyed Hassan Montazam ◽  
Sara Salatin ◽  
Mitra Alami-Milani ◽  
Amir Naderi ◽  
Mitra Jelvehgari
Keyword(s):  
Desirability Function ◽  
Poloxamer 407 ◽  
Gelation Temperature ◽  
Surface Design ◽  
Independent Variables ◽  
Dependent Variables ◽  
Rectal Delivery ◽  
Level Process ◽  
Stability Results

Aim: The aim of the present work was to develop an in situ thermosensitive rectal gel for diazepam by using Expert-design for improving three factors and a three-level process was formed by using a cold method. Methods & materials: Response surface design was utilized to investigate the effect of independent variables like sodium chloride (NaCl, X1), poloxamer 407 (F-127, X2) and diazepam (X3), on different dependent variables such as gelation temperature, mucoadhesive strength, drug content, along with permeation and stability. Results: The obtained results revealed that the addition of diazepam enhanced the gelation temperature of hydrogel while it decreased the gel strength and mucoadhesive force. Conclusion: It is suggested that in situ hydrogels may be suitable candidates for rectal delivery.

Rendez vous with Saturn's rings

1984 ◽  
Vol 75 ◽  
pp. 743-759 ◽  
Author(s):  
Kerry T. Nock
Keyword(s):  
Solar Energy ◽  
Electric Propulsion ◽  
Power Source ◽  
Propulsion System ◽  
Low Thrust ◽  
Ring Plane ◽  
The Earth ◽  
Total Impulse ◽  
Saturn's Rings

ABSTRACTA mission to rendezvous with the rings of Saturn is studied with regard to science rationale and instrumentation and engineering feasibility and design. Future detailedin situexploration of the rings of Saturn will require spacecraft systems with enormous propulsive capability. NASA is currently studying the critical technologies for just such a system, called Nuclear Electric Propulsion (NEP). Electric propulsion is the only technology which can effectively provide the required total impulse for this demanding mission. Furthermore, the power source must be nuclear because the solar energy reaching Saturn is only 1% of that at the Earth. An important aspect of this mission is the ability of the low thrust propulsion system to continuously boost the spacecraft above the ring plane as it spirals in toward Saturn, thus enabling scientific measurements of ring particles from only a few kilometers.

The Use of Advanced Analytical Techniques for Characterization of the Chemical, Physical, and Crystallographic Nature of a Surface

1973 ◽  
Vol 31 ◽  
pp. 132-133 ◽  
Author(s):  
R. E. Herfert
Keyword(s):  
Surface Characterization ◽  
Analytical Techniques ◽  
X Ray Diffraction ◽  
Depth Of Penetration ◽  
X Ray ◽  
The Past ◽  
Transmission Electron ◽  
Scanning Electron

Studies of the nature of a surface, either metallic or nonmetallic, in the past, have been limited to the instrumentation available for these measurements. In the past, optical microscopy, replica transmission electron microscopy, electron or X-ray diffraction and optical or X-ray spectroscopy have provided the means of surface characterization. Actually, some of these techniques are not purely surface; the depth of penetration may be a few thousands of an inch. Within the last five years, instrumentation has been made available which now makes it practical for use to study the outer few 100A of layers and characterize it completely from a chemical, physical, and crystallographic standpoint. The scanning electron microscope (SEM) provides a means of viewing the surface of a material in situ to magnifications as high as 250,000X.

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