scholarly journals Tumor Necrosis Factor α (TNF) Increases Granulosa Cell Proliferation: Dependence on c-Jun and TNF Receptor Type 1

Endocrinology ◽  
2004 ◽  
Vol 145 (3) ◽  
pp. 1218-1226 ◽  
Author(s):  
Deok-Soo Son ◽  
Koji Y. Arai ◽  
Katherine F. Roby ◽  
Paul F. Terranova
Keyword(s):  
Cell Proliferation ◽  
Tumor Necrosis Factor ◽  
Granulosa Cell ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Receptor Type ◽  
Tnf Receptor ◽  
Factor Α ◽  
Necrosis Factor

Soluble tumor necrosis factor-α receptor type 1 during selenium supplementation in psoriasis patients

Nutrition ◽  
2003 ◽  
Vol 19 (10) ◽  
pp. 847-850 ◽  
Author(s):  
Agnieszka B Serwin ◽  
Hanna Mysliwiec ◽  
Katarzyna Hukalowicz ◽  
Piotr Porebski ◽  
Maria Borawska ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Selenium Supplementation ◽  
Receptor Type ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Tumor necrosis factor-α receptor type 1, not type 2, mediates its acute responses in the kidney

2012 ◽  
Vol 302 (12) ◽  
pp. F1650-F1657 ◽  
Author(s):  
Alexander Castillo ◽  
M. Toriqul Islam ◽  
Minolfa C. Prieto ◽  
Dewan S. A. Majid
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Receptor Type ◽  
Tnf Α ◽  
Factor Α ◽  
Renal Vascular ◽  
Necrosis Factor

Acute administration of tumor necrosis factor-α (TNF-α) resulted in decreases in renal blood flow (RBF) and glomerular filtration rate (GFR) but induced diuretic and natriuretic responses in mice. To define the receptor subtypes involved in these renal responses, experiments were conducted to assess the responses to human recombinant TNF-α (0.3 ng·min−1·g body wt−1iv infusion for 75 min) in gene knockout (KO) mice for TNF-α receptor type 1 (TNFαR1 KO, n = 5) or type 2 (TNFαR2 KO, n = 6), and the results were compared with those obtained in corresponding wild-type [WT (C57BL/6), n = 6] mice. Basal levels of RBF (PAH clearance) and GFR (inulin clearance) were similar in TNFαR1 KO, but were lower in TNFαR2 KO, than WT mice. TNF-α infusion in WT mice decreased RBF and GFR but caused a natriuretic response, as reported previously. In TNFαR1 KO mice, TNF-α infusion failed to cause such vasoconstrictor or natriuretic responses; rather, there was an increase in RBF and a decrease in renal vascular resistance. Similar responses were also observed with infusion of murine recombinant TNF-α in TNFαR1 KO mice ( n = 5). However, TNF-α infusion in TNFαR2 KO mice caused changes in renal parameters qualitatively similar to those observed in WT mice. Immunohistochemical analysis in kidney slices from WT mice demonstrated that while both receptor types were generally located in the renal vascular and tubular cells, only TNFαR1 was located in vascular smooth muscle cells. There was an increase in TNFαR1 immunoreactivity in TNFαR2 KO mice, and vice versa, compared with WT mice. Collectively, these functional and immunohistological findings in the present study demonstrate that the activation of TNFαR1, not TNFαR2, is mainly involved in mediating the acute renal vasoconstrictor and natriuretic actions of TNF-α.

Tumor necrosis factor-α inhibitors alleviation of experimentally induced neuropathic pain is associated with modulation of TNF receptor expression

2014 ◽  
Vol 92 (11) ◽  
pp. 1490-1498 ◽  
Author(s):  
Pablo Andrade ◽  
Govert Hoogland ◽  
John S. Del Rosario ◽  
Harry W. Steinbusch ◽  
Veerle Visser-Vandewalle ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Receptor Expression ◽  
Tnf Receptor ◽  
Factor Α ◽  
Necrosis Factor ◽  
Experimentally Induced

scholarly journals Tumor Necrosis Factor α Is Associated With Viral Control and Early Disease Progression in Patients With HIV Type 1 Infection

2014 ◽  
Vol 210 (7) ◽  
pp. 1042-1046 ◽  
Author(s):  
Sagar A. Vaidya ◽  
Christian Korner ◽  
Michael N. Sirignano ◽  
Molly Amero ◽  
Sue Bazner ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Disease Progression ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Early Disease ◽  
Viral Control ◽  
Hiv Type 1 ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Tumor necrosis factor (TNF) receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1

1998 ◽  
Vol 28 (1) ◽  
pp. 257-263 ◽  
Author(s):  
Matthias Grell ◽  
Florian M. Becke ◽  
Harald Wajant ◽  
Daniela N. Männel ◽  
Peter Scheurich
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Receptor Type ◽  
Tnf Receptor ◽  
Thymocyte Proliferation ◽  
Necrosis Factor
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