scholarly journals The Effect of Vertical Sleeve Gastrectomy on a Rat Model of Polycystic Ovarian Syndrome

Endocrinology ◽  
2011 ◽  
Vol 152 (10) ◽  
pp. 3700-3705 ◽  
Author(s):  
Hilary E. Wilson-Pérez ◽  
Randy J. Seeley
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Body Weight ◽  
Glucose Tolerance ◽  
Polycystic Ovarian Syndrome ◽  
Vertical Sleeve Gastrectomy ◽  
Metabolic Disturbances ◽  
Menstrual Dysfunction ◽  
Estrous Cyclicity ◽  
Ovarian Syndrome

Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder of women of reproductive age. Although some of the primary symptoms of PCOS are reproductive abnormalities, including hyperandrogenism, menstrual dysfunction, and hirsutism, other metabolic disturbances are also common, including obesity and insulin resistance. Women with PCOS who have undergone weight-loss bariatric surgery have reported surprising postoperative benefits beyond weight loss, including resolution of menstrual dysfunction and improvement of hirsutism. Here, we use a chronic dihydrotestosterone (DHT) exposure model of PCOS in female rats and investigate the efficacy of a specific type of bariatric surgery, namely vertical sleeve gastrectomy (VSG), to resolve the reproductive and metabolic disturbances induced by DHT treatment. We find that VSG causes loss of body weight and body fat in DHT-treated rats but does not improve glucose tolerance or restore estrous cyclicity. Although human PCOS patients have shown decreased androgen levels after bariatric surgery, the chronic nature of DHT administration in this rat model both before and after VSG renders this effect impossible in this case. Therefore, the lack of improvement in glucose tolerance and estrous cyclicity may implicate a direct effect of androgen knockdown as a mechanism for the improvements seen in human PCOS patients after bariatric surgery. In addition, the dissociation of body weight loss without improved glucose tolerance suggests that glucose intolerance may be a body weight-independent phenomenon in women with PCOS.

scholarly journals Effect of Exercise and Weight Loss in Polycystic Ovarian Syndrome among Obese Women

2021 ◽  
Vol 29 (S1) ◽  
Author(s):  
Thomas Cochrane ◽  
Tengku Fadilah Tengku-Kamalden ◽  
Rachel Davey ◽  
Roxana Dev Omar Dev
Keyword(s):  
Heart Rate ◽  
Weight Loss ◽  
Body Weight ◽  
Polycystic Ovarian Syndrome ◽  
Intervention Group ◽  
Small Sample ◽  
Lean Body Weight ◽  
Obese Women ◽  
Fat Percentage ◽  
Ovarian Syndrome

Ovulation and fertility can be improved by weight loss in obese women with Polycystic Ovarian Syndrome (PCOS). The aim of this study was to investigate the effectiveness of a twelve-week supervised exercise program in combination with dietary restrictions for obese women with PCOS. The study is a quasi-experimental research and used an experimental pre- and post-test design. Fifteen women recruited from Fertility Clinic, Jessops Hospital for Women, Sheffield took part in this study. Respiratory exchange ratio (RER), heart rate, perceived exertion (RPE), and Houston non-exercise activity code were recorded. Height, weight, and body girth measurements were taken to calculate body mass index, fat percentage, and lean body weight. The intervention group lost an average of 3.1 kg and gained 3.45 kg of lean body weight. Loss of fat percentage was 12.1%. No significant difference was found in the control group. The RER and heart rate value decreased for the same workload in the intervention group, indicating higher tolerance towards exercise intensity. However, the changes for both groups were not significant. The average group compliance rate was 53% (at least two sessions per week). Bearing in mind the small sample size (n=4) for control, the improvement in fitness, significant weight loss, and body composition change (increase in fat-free mass) was achieved in this study. Twelve weeks of exercise, combined with dietary advice, were sufficient to benefit PCOS obese women. The research has achieved a commendable weight-loss objective and has demonstrated increases in standards of fitness among obese women.

Weight loss following bariatric surgery in women with polycystic ovarian syndrome and oligomenorrhea

2016 ◽  
Vol 12 (7) ◽  
pp. s121-s122
Author(s):  
Sarah Pivo ◽  
Margaret Nachtigall ◽  
Patricia Chui ◽  
Akuezunkpa Ude Welcome ◽  
John Saunders ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Syndrome

Polycystic Ovarian Syndrome and Bariatric Surgery

2017 ◽  
Vol 12 (3) ◽  
pp. 91-93
Author(s):  
Arinbjorn Jonsson ◽  
Lava Y. Patel ◽  
Arvinpal Singh ◽  
S. Scott Davis ◽  
Edward Lin
Keyword(s):  
Bariatric Surgery ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Syndrome

scholarly journals MON-LB101 5-Year Data of an Aggressive Pharmacological Approach to Moderate and Morbid Obesity: Is Prevention of Bariatric Surgery Feasible in the Long Run?

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Flavio Cadegiani
Keyword(s):  
Bariatric Surgery ◽  
Morbid Obesity ◽  
Weight Loss ◽  
Body Weight ◽  
Weight Regain ◽  
Morbidly Obese ◽  
Biochemical Profile ◽  
Initial Weight ◽  
Initial Weight Loss

Abstract Background: Maintenance of weight loss in patients that undergo weight loss interventions is highly challenging, irrespective of the type of approach to obesity (whether surgical, pharmacological, or non-pharmacological). We proposed a protocol of an aggressive clinical treatment for obesity aiming to prevent the need of bariatric surgery, in patients unwilling to undergo this procedure, by proposing a protocol that included the combination of different anti-obesity medications and non-pharmacological modalities, for longer duration, and with an active approach to prevent weight regain. Our initial 2-year data showed that 93% (40 of 43 patients) with moderate and morbid obesity were able to avoid the need of bariatric surgery, with concomitant improvements of the biochemical profile. However, whether these patients would maintain their successful rates after five years was uncertain. Our objective is to describe the efficacy and safety of a long term (5-year data) pharmacological and multi-modal treatment for moderate and severe obesity. Methods: The 40 patients that were successful in the two-year approach in our obesity center (Corpometria Institute, Brasilia, DF, Brazil) were enrolled. A long-term anti-obesity protocol was employed, with continuous or intermittent use of anti-obesity drugs, trimestral body composition analysis, psychotherapy, visit to a nutritionist every four months, and both resistance and endurance exercises at least four times a week. Body weight (BW), total weight excess (TWE), body fat, markers of lipid and glucose metabolism, liver function, and inflammation were analyzed. Subjects that dropped out were considered as weight regain. Therapeutic success for the 5-year follow-up included as the maintenance of >20% loss of the initial BW loss, and no weight regain (or < 20% of the initial weight loss). Results: A total of 27 patients (67.5%) were able to maintain the body weight, seven dropped out, and six regained more than 20% of the initial weight loss. Of these, 21 (77.8%) had significant further increase of muscle mass and decrease of fat loss, while 17 (63.0%) had further weight loss (p < 0.05), compared to the 2-year data. Improvements on the biochemical profile persisted in all 27 patients, and had significant further improvements in 24 (88.9%) of these patients. Conclusion: The risk of weight regain five years after a weight loss treatment for obesity was significantly lower compared to previous literature, and comparable to the long-term outcomes of bariatric procedures. An aggressive, structured, and long-term clinical weight loss approach has been shown to be feasible, even for morbidly obese patients.

Sleeve Gastrectomy for Obesity in Polycystic Ovarian Syndrome: Weight Loss and Fertility Outcomes

2017 ◽  
Vol 13 (10) ◽  
pp. S15 ◽  
Author(s):  
Joshua Dilday ◽  
Michael Derickson ◽  
John Kuckelman ◽  
Julia Bader ◽  
Eric Ahnfeldt ◽  
...  
Keyword(s):  
Weight Loss ◽  
Sleeve Gastrectomy ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Syndrome
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