scholarly journals Effect of Exercise and Weight Loss in Polycystic Ovarian Syndrome among Obese Women

2021 ◽  
Vol 29 (S1) ◽  
Author(s):  
Thomas Cochrane ◽  
Tengku Fadilah Tengku-Kamalden ◽  
Rachel Davey ◽  
Roxana Dev Omar Dev
Keyword(s):  
Heart Rate ◽  
Weight Loss ◽  
Body Weight ◽  
Polycystic Ovarian Syndrome ◽  
Intervention Group ◽  
Small Sample ◽  
Lean Body Weight ◽  
Obese Women ◽  
Fat Percentage ◽  
Ovarian Syndrome

Ovulation and fertility can be improved by weight loss in obese women with Polycystic Ovarian Syndrome (PCOS). The aim of this study was to investigate the effectiveness of a twelve-week supervised exercise program in combination with dietary restrictions for obese women with PCOS. The study is a quasi-experimental research and used an experimental pre- and post-test design. Fifteen women recruited from Fertility Clinic, Jessops Hospital for Women, Sheffield took part in this study. Respiratory exchange ratio (RER), heart rate, perceived exertion (RPE), and Houston non-exercise activity code were recorded. Height, weight, and body girth measurements were taken to calculate body mass index, fat percentage, and lean body weight. The intervention group lost an average of 3.1 kg and gained 3.45 kg of lean body weight. Loss of fat percentage was 12.1%. No significant difference was found in the control group. The RER and heart rate value decreased for the same workload in the intervention group, indicating higher tolerance towards exercise intensity. However, the changes for both groups were not significant. The average group compliance rate was 53% (at least two sessions per week). Bearing in mind the small sample size (n=4) for control, the improvement in fitness, significant weight loss, and body composition change (increase in fat-free mass) was achieved in this study. Twelve weeks of exercise, combined with dietary advice, were sufficient to benefit PCOS obese women. The research has achieved a commendable weight-loss objective and has demonstrated increases in standards of fitness among obese women.

scholarly journals The Effect of Vertical Sleeve Gastrectomy on a Rat Model of Polycystic Ovarian Syndrome

Endocrinology ◽  
2011 ◽  
Vol 152 (10) ◽  
pp. 3700-3705 ◽  
Author(s):  
Hilary E. Wilson-Pérez ◽  
Randy J. Seeley
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Body Weight ◽  
Glucose Tolerance ◽  
Polycystic Ovarian Syndrome ◽  
Vertical Sleeve Gastrectomy ◽  
Metabolic Disturbances ◽  
Menstrual Dysfunction ◽  
Estrous Cyclicity ◽  
Ovarian Syndrome

Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder of women of reproductive age. Although some of the primary symptoms of PCOS are reproductive abnormalities, including hyperandrogenism, menstrual dysfunction, and hirsutism, other metabolic disturbances are also common, including obesity and insulin resistance. Women with PCOS who have undergone weight-loss bariatric surgery have reported surprising postoperative benefits beyond weight loss, including resolution of menstrual dysfunction and improvement of hirsutism. Here, we use a chronic dihydrotestosterone (DHT) exposure model of PCOS in female rats and investigate the efficacy of a specific type of bariatric surgery, namely vertical sleeve gastrectomy (VSG), to resolve the reproductive and metabolic disturbances induced by DHT treatment. We find that VSG causes loss of body weight and body fat in DHT-treated rats but does not improve glucose tolerance or restore estrous cyclicity. Although human PCOS patients have shown decreased androgen levels after bariatric surgery, the chronic nature of DHT administration in this rat model both before and after VSG renders this effect impossible in this case. Therefore, the lack of improvement in glucose tolerance and estrous cyclicity may implicate a direct effect of androgen knockdown as a mechanism for the improvements seen in human PCOS patients after bariatric surgery. In addition, the dissociation of body weight loss without improved glucose tolerance suggests that glucose intolerance may be a body weight-independent phenomenon in women with PCOS.

scholarly journals EFFECTIVENESS OF LIFESTYLE MODIFICATION ON WEIGHTLOSS AND QUALITY OF LIFE IN OBESE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME

2018 ◽  
Vol 11 (9) ◽  
pp. 333
Author(s):  
Vinaya Rajendra Patil ◽  
Poovishnu Devi Thangavelu ◽  
Vaishali Krishnat Jagtap
Keyword(s):  
Quality Of Life ◽  
Weight Loss ◽  
Polycystic Ovarian Syndrome ◽  
Lifestyle Modification ◽  
Obese Women ◽  
Group A ◽  
Conventional Physiotherapy ◽  
Group B ◽  
Ovarian Syndrome

Objectives: (1) The objectives of this study were to determine the effectiveness of lifestyle modification on weight loss and the quality of life in obese women with the polycystic ovarian syndrome and (2) to determine the effectiveness of conventional physiotherapy on weight loss and the quality of life in obese women with polycystic ovarian syndrome.Methods: Ethical clearance was obtained from the Institutional Ethical Committee. A total of 40 obese women with the polycystic ovarian syndrome (PCOS) were selected and divided into two groups, Group A (N=17) received conventional physiotherapy alone, and Group B (n=15) received lifestyle modification along with conventional physiotherapy. The preassessment of body weight is measured by body mass index (BMI); the waist-hip ratio (W-H ratio) and body fat percentage and the quality of life were scored as per the PCOS questionnaire (PCOSQ); and postinterventional assessment was taken for the same after 9 months.Result: Intergroup statistical analysis for BMI revealed extremely significant in postintervention for Group B (P<0.0001). W-H ratio and PCOSQ were extremely significant for Group B (P<0.0001). While postintervention analysis showed extremely significant difference between Group A and Group B (P<0.0001). Group B treated with lifestyle modification, and conventional physiotherapy was extremely significant.Conclusion: Lifestyle modification with conventional physiotherapy helped in reducing weight and showed the increased quality of life in women with PCOS.

Evaluation of endothelial function in obese and non obese women with polycystic ovarian syndrome

Authorea ◽  
2020 ◽  
Author(s):  
Gita Radhakrishnan ◽  
Anshuja Singla ◽  
Mamta Jakhar ◽  
Rachna Agarwal ◽  
Anupama Tandon ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Polycystic Ovarian Syndrome ◽  
Obese Women ◽  
Ovarian Syndrome

scholarly journals Impact of Experimentally Induced Cognitive Dietary Restraint on Eating Behavior Traits, Appetite Sensations, and Markers of Stress during Energy Restriction in Overweight/Obese Women

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Isabelle Morin ◽  
Catherine Bégin ◽  
Julie Maltais-Giguère ◽  
Alexandra Bédard ◽  
André Tchernof ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Eating Behavior ◽  
Perceived Stress ◽  
Negative Impact ◽  
Dietary Restraint ◽  
Premenopausal Women ◽  
Energy Restriction ◽  
Obese Women ◽  
Experimentally Induced

Weight loss has been associated with changes in eating behaviors and appetite sensations that favor a regain in body weight. Since traditional weight loss approaches emphasize the importance of increasing cognitive dietary restraint (CDR) to achieve negative energy imbalance, it is difficult to untangle the respective contributions of energy restriction and increases in CDR on factors that can eventually lead to body weight regain. The present study aimed at comparing the effects of energy restriction alone or in combination with experimentally induced CDR on eating behavior traits, appetite sensations, and markers of stress in overweight and obese women. We hypothesized that the combination of energy restriction and induced CDR would lead to more prevalent food cravings, increased appetite sensations, and higher cortisol concentrations than when energy restriction is not coupled with induced CDR. A total of 60 premenopausal women (mean BMI: 32.0 kg/m2; mean age: 39.4 y) were provided with a low energy density diet corresponding to 85% of their energy needs during a 4-week fully controlled period. At the same time, women were randomized to either a condition inducing an increase in CDR (CDR+ group) or a condition in which CDR was not induced (CRD− group). Eating behavior traits (Three-Factor Eating Questionnaire and Food Craving Questionnaire), appetite sensations (after standardized breakfast), and markers of stress (Perceived Stress Scale; postawakening salivary cortisol) were measured before (T = 0 week) and after (T = 4 weeks) the 4-week energy restriction, as well as 3 months later. There was an increase in CDR in the CDR+ group while no such change was observed in the CDR− group (p=0.0037). No between-group differences were observed for disinhibition, hunger, cravings, appetite sensations, perceived stress, and cortisol concentrations. These results suggest that a slight increase in CDR has no negative impact on factors regulating energy balance in the context of energy restriction.

Abstract MP016: Innovation in Exercise: Increasing Capacity of Sedentary Obese Women with Cooling

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Stacy T Sims ◽  
Sandra Tsai ◽  
Marcia L Stefanick
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Body Weight ◽  
Waist Circumference ◽  
Body Mass ◽  
Exercise Tolerance ◽  
Thermal Strain ◽  
Walk Test ◽  
Obese Women ◽  
Thermal Discomfort

Background: Barriers to physical activity for obese women include overheating, sweating, fatigue, exhaustion, and rapid heart rate. Adipose tissue acts as a thermal insulator, promoting a greater heat load on the nonfat tissues, reducing heat tolerance; exercise causes a rise in body temperature with an inability to dissipate heat contributing to reduced exercise tolerance. With difficulties of thermoregulation in the sedentary obese population, the aspect of attenuating the discomfort thus associated may encourage continuation of exercise. A heat sink applied to palmar surfaces extracts heat and cools the venous blood, reducing thermal strain by enhancing the volume of cooled venous return. We hypothesized that palmar cooling using a rapid thermal exchange device (RTX) during exercise would attenuate the thermal discomfort of exercise of sedentary obese women, improving exercise tolerance. Methods: To examine whether palmar cooling would impact exercise tolerance in obese women, 24 healthy women aged 30–45 years, with no history of long term structured exercise, a body mass of 120–135% above ideal and/or BMI between 30 and 34.9 were recruited. Women were randomized into a cooling (RXT with 16°C water circulating) or a control (RTX with 37°C water circulating) group and attended 3 exercise sessions a week for 3-months (12 weeks). Each session was comprised of 10 min body weight exercises, 25–45 min treadmill walking at 70–85% HRR with the RTX device, and 10 min of core strengthening exercises. The performance marker was a 1.5 mi walk for time; conducted on the first and last days of the intervention. Mixed models were used to model each of the outcomes as a function of thermal strain, time and treatment with covariates of speed, heart rate, distance, and the interaction of the main effects included in the model. Results: Groups were matched at baseline for key variables (time for 1.5 mile walk test, resting and exercising heart rate [HR], blood pressure [BP], waist circumference [WC], body weight, body mass index [BMI]). Among the cooling group, time to complete the 1.5mile walk test was significantly faster (31.6 ± 2.3 vs. 24.6 ± 2.5 min, pre vs. post, P< 0.01). A greater average exercising HR was observed (136 vs. 154 bpm, pre vs. post, P <0.001), with a significant reduction in WC (41.8 ± 3.1 vs. 39.1 ± 2.2 inches, pre vs. post, P< 0.01) and resting BP (139/84 ± 124/70 mmHg, pre vs. post, P < 0.025). There were no significant differences observed in the control group. Conclusion: Results indicate that exercise tolerance in obese women improved with cooling during exercise, more so than those women who did not have cooling. An improvement in blood pressure, heart rate, waist circumference, and overall aerobic fitness was observed. These findings suggest that by reducing thermal discomfort during exercise, tolerance increases, thus improving cardiovascular parameters of obese women.

scholarly journals TNF-[alpha] and adiponectin pathways are deregulated in endometria from obese women with polycystic ovarian syndrome

2015 ◽  
Author(s):  
Lorena Orostica ◽  
Isis Astorga ◽  
Victor Garcia ◽  
Cristian Poblete ◽  
Carmen Romero ◽  
...  
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Tnf Alpha ◽  
Obese Women ◽  
Ovarian Syndrome

scholarly journals The value of blood serotonin for effective weight loss in obese women

2015 ◽  
Vol 12 (3) ◽  
pp. 31-35
Author(s):  
Natal'ya Vadimovna Anikina ◽  
Elena Nikolaevna Smirnova
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Clinical Laboratory ◽  
Normal Weight ◽  
Obese Patients ◽  
Obese Women ◽  
Endothelin 1 ◽  
Excessive Accumulation ◽  
Made In

Introduction. Obesity is a disorder of energy balance, which leads to excessive accumulation of fat. In recent years, many important discoveries were made in this field, including the discovery of hormones produced by adipose tissue and the identification of many of the central and peripheral pathways of energy balance.Objective. To study the levels of hormones that affect appetite and metabolism in women with obesity baseline and after weight loss while taking sibutramine.Materials and methods. The study included 56 women aged 42,9±9,5 years, with a BMI of 34,6±6,1 kg/m2. All patients underwent clinical, laboratory and instrumental examination. Hormonal study included determination of serotonin, leptin, ghrelin, endothelin-1, adiponectin.Results: In women with obesity we identified hyperleptinemia and increased serotonin levels. The decrease in body weight in patients receiving sibutramine was accompanied by lower levels of serotonin, leptin, ghrelin, endothelin-1, and increase of adiponectin.Conclusions: Obese patients have significantly elevated levels of leptin, serotonin, ghrelin compared to women of normal weight. Sibutramine treatment leads to a decrease in serotonin, leptin, ghrelin and is more effective in women with a BMI less than 36,5 kg/m2.

Increased circadian prolactin release is blunted after body weight loss in obese premenopausal women

2006 ◽  
Vol 290 (2) ◽  
pp. E218-E224 ◽  
Author(s):  
Petra Kok ◽  
Ferdinand Roelfsema ◽  
Janneke G. Langendonk ◽  
Caroline C. de Wit ◽  
Marijke Frölich ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Premenopausal Women ◽  
Body Weight Loss ◽  
Wave Form ◽  
Obese Women ◽  
Very Low Calorie Diet ◽  
Burst Frequency ◽  
Dopamine 2 Receptor ◽  
Plasma Prl

We recently showed that prolactin (PRL) release is considerably enhanced in obese women in proportion to the size of their visceral fat mass. PRL release is inhibited by dopamine 2 receptor (D2R) activation, and dietary restriction/weight loss are associated with increased dopaminergic signaling in animals. Therefore, we hypothesized that enhanced PRL release in obese humans would be reversed by weight loss. To evaluate this postulate, we measured 24-h plasma PRL concentrations at 10-min intervals in 11 obese premenopausal women (BMI 33.3 ± 0.7 kg/m2) before and after weight loss (50% reduction of overweight/15% absolute weight loss, using a very low-calorie diet) in the follicular phase of their menstrual cycle. The 24-h PRL concentration profiles were analyzed by a peak detection program (Cluster) and a wave form-independent deconvolution technique (Pulse). Spontaneous 24-h PRL secretion was significantly reduced in obese women [mean daily release, before 128 ± 24 vs. after weight loss 110 ± 17 μg/liter distribution volume (Vdl)−1 × 24 h, P = 0.05]. Body weight loss particularly blunted PRL secretory burst mass (Pulse area, before 230 ± 28 vs. after weight loss 221 ± 31 μg/Vdl−1 × 24 h, P = 0.03), whereas burst frequency was unaffected (no. of pulses, before 11 ± 1 vs. after weight loss 12 ± 1 n/24 h, P = 0.69). Thus elevated PRL secretion rate in obese women is significantly reduced after loss of 50% of overweight. We speculate that amelioration of deficit D2R-mediated neurotransmission and/or diminutions of circulating leptin/estrogen levels might be involved in the physiology of this phenomenon.

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