Transforming growth factor-beta gene family members and bone

1994 ◽  
Vol 15 (1) ◽  
pp. 27-39 ◽  
Author(s):  
M. Centrella
Keyword(s):  
Growth Factor ◽  
Gene Family ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Family Members ◽  
Growth Factor Beta ◽  
Beta Gene

Transforming Growth Factor Beta (TGF-β) Gene Family Members in Developing and Neoplastic Odontogenic Tissues

2006 ◽  
Vol 15 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Kristiina Heikinheimo ◽  
Kazuhisa Mori ◽  
Hitoshi Nagatsuka ◽  
Risto-Pekka Happonen
Keyword(s):  
Growth Factor ◽  
Gene Family ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Family Members ◽  
Tgf Beta ◽  
Growth Factor Beta ◽  
Beta Gene

scholarly journals Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily.

1989 ◽  
Vol 86 (12) ◽  
pp. 4554-4558 ◽  
Author(s):  
K. Lyons ◽  
J. L. Graycar ◽  
A. Lee ◽  
S. Hashmi ◽  
P. B. Lindquist ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Mammalian Gene ◽  
Growth Factor Beta ◽  
Beta Gene

scholarly journals Protection of the prodomain 1-helix correlates with latency in the transforming growth factor- family

2021 ◽  
Author(s):  
Viet Q. Le ◽  
Bo Zhao ◽  
Roxana E. Iacob ◽  
Yuan Tian ◽  
Cameron Toohey ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Family Members ◽  
Sequence Divergence ◽  
Negative Stain ◽  
Hydrogen Deuterium ◽  
Growth Factor Beta ◽  
Organismal Development ◽  
Pi Bonds

The 33 members of the transforming growth factor beta (TGF-) family are fundamentally important for organismal development and homeostasis. Family members are synthesized and secreted as pro-complexes of prodomains that are non-covalently bound to the growth factor (GF). The pro-complexes of some members are latent and require activation steps to release the GF for signaling. Why some members are latent while others are non-latent is incompletely understood, but crystal structures and hydrogen-deuterium exchange (HDX) of four family members have begun to unravel how latency is regulated. Here, we extend this understanding by comparing pro-complex conformation in negative stain EM (nsEM) and HDX of ActA, BMP7, BMP9, BMP10, GDF8, TGF-1, and TGF-2. nsEM revealed that family members varied in either adopting cross-armed, open-armed, or V-armed configurations. Latency was achieved in both cross-armed and V-armed but not open-armed conformations. HDX revealed remarkably varying patterns of exchange between family members, consistent with large prodomain sequence divergence. We observed a strong correlation between latency and protection of the prodomain 1-helix from exchange, which in latent members coincided with greater buried surface area of the 1-helix and more hydrogen and cation-pi bonds from the prodomain fastener and GF to the 1-helix. Strong sequence conservation of the 1-helix and fastener only in latent members suggests that similar interactions are conserved and sufficient to confer latency. Moreover, most members exhibited rapid exchange in the unstructured association region at the prodomain N-terminus, highlighting their availability for interacting with factors that may regulate latency and extracellular storage.

scholarly journals Trastuzumab treatment is associated with elevated transforming growth factor beta gene expression.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Human Breast Cancer ◽  
Transforming Growth Factor ◽  
Expression Data ◽  
Human Breast ◽  
Trastuzumab Treatment ◽  
Growth Factor Beta ◽  
Beta Gene

The transforming growth factor beta superfamily, as its name implies, is critical for oncogenesis in multiple cellular contexts (1-8). We found, through mining published microarray and multiplexed gene expression data (9-11), that administration of trastuzumab was associated with increased expression of TGFBR1 and TGFBI. These data serve as one piece of evidence arguing against the use of trastuzumab in human breast cancer, a patient population already prone to difficult-to-treat metastases (12-15).

The effect of Transforming Growth Factor Beta family members on tumor initiating cells in primary liver cancer

2016 ◽  
Vol 54 (12) ◽  
pp. 1343-1404
Author(s):  
SP Pereira ◽  
LZ Rodrigues ◽  
D Castven ◽  
S Dooley ◽  
NMM Meindl-Beinker ◽  
...  
Keyword(s):  
Growth Factor ◽  
Liver Cancer ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Primary Liver Cancer ◽  
Family Members ◽  
Tumor Initiating Cells ◽  
Growth Factor Beta

Procollagen Types I and III and Transforming Growth Factor-Beta Gene Expression in the Arterial Wall after Exposure to Periarterial Blood

Neurosurgery ◽  
1993 ◽  
Vol 33 (4) ◽  
pp. 716-722 ◽  
Author(s):  
Hidetoshi Kasuya ◽  
Bryce Weir ◽  
Youjun Shen ◽  
Gregory Hariton ◽  
Bozena Vollrath ◽  
...  
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Arterial Wall ◽  
Transforming Growth Factor ◽  
Growth Factor Beta ◽  
Beta Gene
Sign in / Sign up

Export Citation Format

Share Document