Isolation of Vgr-2, a novel member of the transforming growth factor- beta-related gene family

1992 ◽  
Vol 6 (11) ◽  
pp. 1961-1968 ◽  
Author(s):  
C. M. Jones
Keyword(s):  
Growth Factor ◽  
Gene Family ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Related Gene ◽  
Growth Factor Beta

scholarly journals Isolation of Vgr-2, a novel member of the transforming growth factor-beta-related gene family.

1992 ◽  
Vol 6 (11) ◽  
pp. 1961-1968
Author(s):  
C M Jones ◽  
D Simon-Chazottes ◽  
J L Guenet ◽  
B L Hogan
Keyword(s):  
Growth Factor ◽  
Gene Family ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Related Gene ◽  
Growth Factor Beta

Transforming Growth Factor Beta (TGF-β) Gene Family Members in Developing and Neoplastic Odontogenic Tissues

2006 ◽  
Vol 15 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Kristiina Heikinheimo ◽  
Kazuhisa Mori ◽  
Hitoshi Nagatsuka ◽  
Risto-Pekka Happonen
Keyword(s):  
Growth Factor ◽  
Gene Family ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Family Members ◽  
Tgf Beta ◽  
Growth Factor Beta ◽  
Beta Gene

scholarly journals Evolution of Nodal and Nodal-related genes and the putative composition of the heterodimer that triggers the Nodal pathway in vertebrates

2018 ◽  
Author(s):  
Juan C. Opazo ◽  
Shigehiro Kuraku ◽  
Kattina Zavala ◽  
Jessica Toloza-Villalobos ◽  
Federico G. Hoffmann
Keyword(s):  
Growth Factor ◽  
Gene Family ◽  
Transforming Growth Factor Beta ◽  
Evolutionary History ◽  
Transforming Growth Factor ◽  
Signaling Molecule ◽  
Number Of Genes ◽  
Differential Retention ◽  
History Of ◽  
Growth Factor Beta

AbstractNodal is a signaling molecule that belongs to the transforming growth factor-beta superfamily that plays key roles during the early stages of development of animals. Nodal forms an heterodimer with a GDF1/3 protein to activate the Nodal pathway. Vertebrates have a paralog of nodal in their genomes labeled Nodal related, but the evolutionary history of these genes is a matter of debate, mainly because of variable numbers of genes in the vertebrate genomes sequenced so far. Thus, the goal of this study was to investigate the evolutionary history of the Nodal and Nodal-related genes with an emphasis in tracking changes in the number of genes among vertebrates. Our results show the presence of two gene lineages (Nodal and Nodal-related) that can be traced back to the ancestor of jawed vertebrates. These lineages have undergone processes of differential retention and lineage-specific expansions. Our results imply that Nodal and Nodal-related duplicated at the latest in the ancestor of gnathostomes, and they still retain a significant level of functional redundancy. By comparing the evolution of the Nodal/Nodal-related with GDF1/3 gene family, it is possible to infer that there are at least four types of heterodimers that can trigger the Nodal pathway among vertebrates.

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