scholarly journals Radioactive Iodine Therapy for Goitrous Hashimoto’s Thyroiditis

2006 ◽  
Vol 91 (11) ◽  
pp. 4497-4500 ◽  
Author(s):  
Junichi Tajiri
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Radioactive Iodine ◽  
Clinical Symptoms ◽  
Hashimoto's Thyroiditis ◽  
Average Weight ◽  
Outpatient Basis ◽  
Large Size ◽  
Large Goiter ◽  
Tsh Suppression Therapy ◽  
Student’S T

Abstract Context: Hashimoto’s thyroiditis is an autoimmune disease that can produce marked clinical symptoms when patients have large diffuse goiters. Design: This retrospective cohort study was designed to evaluate whether radioactive iodine (RAI) is effective for Hashimoto’s thyroiditis with a large goiter. Starting in November 1999, 13 Hashimoto’s patients with large goiters, whose thyroiditis was refractory to TSH suppression therapy with thyroid hormone administration [two men and 11 women with a mean age of 61.2 ± 8.9 yr (50–79 yr)], were recruited for the present study. The duration of symptomatic goiter before undergoing RAI was 12.0 ± 7.9 yr (4–33 yr). Thirteen millicuries of 131I was administered two to six times, at an interval of 1–6 months on an outpatient basis. Thyroid weight was measured ultrasonographically, or by computed tomography if ultrasound was not possible due to the large size of the goiter. Results: RAI was administered an average of 4.7 ± 1.4 times (two to six times), with a total dose of 59.8 ± 17.3 mCi (25.0–78.0 mCi). The observation period was 47.9 ± 13.4 months (26–66 months) after the first RAI. The average weight of the thyroid gland was 125.3 ± 57.7 g (42.9–269.4 g) before the first RAI, decreasing significantly to 49.7 ± 25.8 g (18.3–93.3 g) after the last RAI (P < 0.001, paired Student’s t test). The percent reduction from baseline was 58.7 ± 14.2% (35.7–84.0%). None of the patients showed an increase in goiter size or complained of a pressure sensation after any of the RAI treatments. Conclusion: RAI is effective in Hashimoto’s thyroiditis with a large goiter.

Megalo-Goitrous Form of Hashimoto's Thyroiditis: A Rare Indication for Surgery

2012 ◽  
Vol 4 (1) ◽  
pp. 15-16
Author(s):  
Bhargav PRK ◽  
V Amar ◽  
SK Uday
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Rare Case ◽  
Clinical Presentation ◽  
Hashimoto's Thyroiditis ◽  
Indication For Surgery ◽  
Thyroxine Treatment ◽  
Large Goiter

ABSTRACT Hashimoto's thyroiditis (HT) is the commonest cause of hypothyroidism, especially in iodine replete areas. The clinical presentation of HT is usually insidious with mild goiter and progressive hypothyroidism. But, HT presents with large goiter and compressive symptoms in some cases. The treatment of HT is mostly conservative with thyroxine treatment sooner or later. Occasionally, surgery is indicated for large goiters with persistent pressure symptoms or associated nodules. We report a rare case of unusually large goiter with compressive symptoms, hitherto unreported in literature. How to cite this article Bhargav PRK, Amar V, Uday SK. Megalo-Goitrous Form of Hashimoto's Thyroiditis: A Rare Indication for Surgery. World J Endocr Surg 2012;4(1):15-16.

scholarly journals Radioactive Iodine Studies in the Diagnosis of Hashimoto's Thyroiditis

BMJ ◽  
1960 ◽  
Vol 1 (5176) ◽  
pp. 838-841 ◽  
Author(s):  
I. P. C. Murray ◽  
E. M. McGirr
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Radioactive Iodine ◽  
Hashimoto's Thyroiditis

scholarly journals Cytokine/Chemokine/Growth Factor Profiles Contribute to Understanding the Pathogenesis of the Salivary Gland Dysfunction in Euthyroid Hashimoto’s Thyroiditis Patients

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
K. Morawska ◽  
M. Maciejczyk ◽  
S. Zięba ◽  
Ł. Popławski ◽  
A. Kita-Popławska ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Growth Factors ◽  
Salivary Glands ◽  
Hashimoto’S Thyroiditis ◽  
Clinical Symptoms ◽  
Hormonal Treatment ◽  
Hashimoto's Thyroiditis ◽  
Salivary Gland Dysfunction ◽  
Whole Saliva ◽  
Unstimulated Whole Saliva

Hashimoto’s thyroiditis (HT) is one of the most common autoimmune diseases. It is suggested that, in addition to thyroid gland dysfunction, HT is responsible for impaired secretion from the salivary glands. The aim of this study was to evaluate the extent of symptoms of salivary gland dysfunction. We also assessed the relationship between the levels of selected cytokines, chemokines, and growth factors in unstimulated whole saliva (UWS) and the rate of UWS secretion and symptoms of xerostomia in HT patients. The study group consisted of 25 female patients diagnosed with Hashimoto’s disease in its spontaneous euthyroid state who had never received hormonal treatment. In more than half of the examined patients, we observed the level of UWS secretion below 0.2 mL/min, indicating impaired secretory function of the salivary glands. Moreover, we demonstrated that the clinical symptoms of salivary gland dysfunction worsen with disease duration. Nevertheless, the inflammatory changes occurring in these glands are independent of general inflammation in the course of HT. Our results clearly indicate an abnormal profile of cytokines, chemokines, and growth factors in the UWS of HT euthyroid women as well as the fact that concentrations of IL-6 and IL-1 as well as INF-γ, TNF-α, and IL-12 may be potential biomarkers for salivary gland dysfunction in the course of HT. Furthermore, salivary IL-12 (p40) may be helpful in assessing the progression of autoimmunity-related inflammation in the course of HT. In conclusion, secretory dysfunction of the salivary glands is closely related to autoimmunity-related inflammation in the course of HT, which leads to objective and subjective symptoms of dry mouth.

Coexistence of dyschondrosteosis associated to SHOX deficiency, pseudohypoparathyroidism 1B, and chronic autoimmune thyroiditis: a case report

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Fernando Marin ◽  
Esteban Jodar ◽  
Jaime Sánchez del Pozo
Keyword(s):  
Case Report ◽  
Parathyroid Hormone ◽  
Hashimoto’S Thyroiditis ◽  
Unusual Case ◽  
Clinical Symptoms ◽  
Large Deletion ◽  
Hashimoto's Thyroiditis ◽  
Chronic Autoimmune Thyroiditis ◽  
Methylation Alteration ◽  
Biochemical Abnormalities

AbstractWe present an unusual case of SHOX deficiency associated with Léri-Weill dyschondrosteosis (LWD), Hashimoto’s thyroiditis and pseudohypoparathyroidism 1B in a young woman. To our knowledge, this is the first ever report of these disorders coexisting. At the age of nine years, the proband was diagnosed of hypothyroidism due to Hashimoto’s thyroiditis, and developed biochemical abnormalities consistent with hyperphosphatemia, mild hypocalcemia and elevated parathyroid hormone without any clinical symptoms except short stature. Replacement therapy with levothyroxine, calcium and alphacalcidol was initiated. The diagnosis of pseudohypoparathyroidism 1B was confirmed at the age of 17.5 years with the demonstration of methylation alteration at the GNAS locus. At the age of 16 years, 3.5 years after her menarche, she presented clear features of LWD. A large deletion of the SHOX gene was confirmed. Family genetic tests were not doable since she was adopted. We discuss the diagnostic challenges of these coexisting rare endocrinopathies.

scholarly journals Acne: modern approaches to solving an old problem

2020 ◽  
Vol 96 (5) ◽  
pp. 31-38
Author(s):  
Z. Z. Kardashova ◽  
I. A. Vasilenko ◽  
E. V. Rusanova ◽  
V. V. Schelkova
Keyword(s):  
Clinical Symptoms ◽  
Platelet Rich Plasma ◽  
Statistical Significance ◽  
Integrated Approach ◽  
Therapeutic Effects ◽  
Outpatient Basis ◽  
Bacteriophage Therapy ◽  
Acne Therapy ◽  
Student’S T ◽  
One Year

Background. Acne is one of the most common chronic dermatoses, which occurs in almost 8590% of the population. The disease manifests itself as polymorphic eruptions and is characterized by a recurrent and torpid course. Acne treatment is constantly improving, requires an integrated approach and long courses of therapy. Aims. To increase the effectiveness of acne therapy using new opportunities and promising methodological approaches using a combination of the therapeutic effects of platelet-rich plasma (PRP) and topical bacteriophage therapy. Materials and methods. The study included 30 patients with papulopustular acne of mild and moderate severity. Patients with mild acne were treated with PRP procedures as monotherapy. For moderate acne, PRP therapy was combined with regular applications of a staphylococcal bacteriophage (NPO Microgen, Nizhny Novgorod, Russia). The treatment was carried out on an outpatient basis: at least 3 procedures with an interval of 12 weeks (up to a maximum of 6 procedures within one year). The results were analyzed using descriptive statistics and the parametric Student's t-test. Data processing was carried out using the Biostat software. The value of the level of statistical significance of differences was taken as p 0.05. Results. Evaluation of the effectiveness of treatment was carried out on the basis of an analysis of the immediate outcomes of the disease, the dynamics of clinical symptoms and the severity of acne: regression of inflammatory elements of acne, a decrease in the phenomenon of seborrhea, improvement of the skin relief. As a result of the therapy, a transition to remission was noted in 16.6% of patients, an improvement in their condition 36.7%, a significant improvement 46.7%. Conclusions. An integrated approach combining PRP procedures and bacteriophage therapy can serve as a pathogenetically substantiated strategy for treating acne. A promising direction for further research is the development of new regimens and combinations of alternative therapeutic strategies using bacteriophages.

scholarly journals Acne: modern approaches to solving an old problem

2020 ◽  
Vol 96 (5) ◽  
pp. 31-38
Author(s):  
Z. Z. Kardashova ◽  
I. A. Vasilenko ◽  
E. V. Rusanova ◽  
V. V. Schelkova
Keyword(s):  
Clinical Symptoms ◽  
Platelet Rich Plasma ◽  
Statistical Significance ◽  
Integrated Approach ◽  
Therapeutic Effects ◽  
Outpatient Basis ◽  
Bacteriophage Therapy ◽  
Acne Therapy ◽  
Student’S T ◽  
One Year

Background. Acne is one of the most common chronic dermatoses, which occurs in almost 8590% of the population. The disease manifests itself as polymorphic eruptions and is characterized by a recurrent and torpid course. Acne treatment is constantly improving, requires an integrated approach and long courses of therapy. Aims. To increase the effectiveness of acne therapy using new opportunities and promising methodological approaches using a combination of the therapeutic effects of platelet-rich plasma (PRP) and topical bacteriophage therapy. Materials and methods. The study included 30 patients with papulopustular acne of mild and moderate severity. Patients with mild acne were treated with PRP procedures as monotherapy. For moderate acne, PRP therapy was combined with regular applications of a staphylococcal bacteriophage (NPO Microgen, Nizhny Novgorod, Russia). The treatment was carried out on an outpatient basis: at least 3 procedures with an interval of 12 weeks (up to a maximum of 6 procedures within one year). The results were analyzed using descriptive statistics and the parametric Student's t-test. Data processing was carried out using the Biostat software. The value of the level of statistical significance of differences was taken as p 0.05. Results. Evaluation of the effectiveness of treatment was carried out on the basis of an analysis of the immediate outcomes of the disease, the dynamics of clinical symptoms and the severity of acne: regression of inflammatory elements of acne, a decrease in the phenomenon of seborrhea, improvement of the skin relief. As a result of the therapy, a transition to remission was noted in 16.6% of patients, an improvement in their condition 36.7%, a significant improvement 46.7%. Conclusions. An integrated approach combining PRP procedures and bacteriophage therapy can serve as a pathogenetically substantiated strategy for treating acne. A promising direction for further research is the development of new regimens and combinations of alternative therapeutic strategies using bacteriophages.

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