Serum Chromogranin A Concentration in Hyperthyroidism before and after Medical Treatment

Background: We aimed prospectively investigate the laboratory and electrocardiographic parameters (hearth rate, QRS, QT, QTc, Tpe, Tpe/QTc, arrhythmia prevalance) in patients with graves disease before and after antithyroid therapy. Methods: 71 patients (48 female, 23 male), age between 18-50 (mean±SD: 36.48±12.20 ) with GD were included into the study. Patients treated with antithyroid therapy (thionamids and/or surgical therapy) to maintain euthyroid status. Patients were examined in terms of electrocardiographic parameters before and after the treatment. Results: Mean TSH, free thyroxin (fT4) and tri-iodothyrionine (fT3) levels of all patients were 0.005±0.21, 3.27± 1.81, 11.42±7.44, respectively. While 9 patients (group 2) underwent surgical therapy, had suspicious of malignant nodule or large goiter and unresponsiveness to medical treatment; the other patients (n=62, group 1) were treated with medical therapy. Patients with surgical therapy had more increased serum fT4 (p=0.045), anti-thyroglobulin value (p=0.018) and more severe graves orbitopathy (n=0.051) before treatment when compared to medical therapy group. Baseline Tpe duration and baseline Tpe/QTc ratio and frequency of supraventricular ectopic beats were found to be significantly higher in group 2 when compared to group 1 (p=0.00, p=0.005). Otherwise baseline mean heart rate, QRS duration, QTc values of both groups were similar. Although the patients became their euthyroid status, group 2 patients had still suffered from more sustained supraventricular ectopics beats than group 1. Conclusion: Distinct from medical treatment group, surgical treatment group with euthyroidism at least 3 months had still suffered from an arrhythmia (Tpe, Tpe/QTc, supraventricular and ventricular ectopic beats).

Download Full-text

Glucose turnover, fuel oxidation and forearm substrate exchange in patients with thyrotoxicosis before and after medical treatment

Clinical Endocrinology ◽

10.1046/j.1365-2265.1996.692514.x ◽

1996 ◽

Vol 44 (4) ◽

pp. 453-459 ◽

Cited By ~ 19

Author(s):

Niels Møller ◽

Søren Nielsen ◽

Birgit Nyholm ◽

Niels Pørksen ◽

K. George ◽

...

Keyword(s):

Medical Treatment ◽

Glucose Turnover ◽

Fuel Oxidation ◽

Before And After

Download Full-text

Levels of Patient Satisfaction on Integrative Medicine Before and After Implementation of Diagnosis-related Groups

Global Advances in Health and Medicine ◽

10.1177/2164956118759256 ◽

2018 ◽

Vol 7 ◽

pp. 216495611875925 ◽

Cited By ~ 3

Author(s):

Tobias Romeyke ◽

Elisabeth Noehammer ◽

Hans Christoph Scheuer ◽

Harald Stummer

Keyword(s):

Patient Satisfaction ◽

Medical Treatment ◽

Diagnosis Related Groups ◽

Hospital Setting ◽

Nutrition Therapy ◽

Study Patient ◽

Patient Centered ◽

General Evaluation ◽

Conventional Medical Treatment ◽

Before And After

Objectives The aim of this article is to study patient satisfaction with complementary and alternative medicine (CAM) in an in-hospital setting before and after the introduction of diagnosis-related groups (DRGs). Methods Patients were interviewed regarding a general evaluation of their hospital stay, the psychological talking therapy, the nutrition therapy, and the overall success of the treatment. Results The medical treatment was evaluated by 1158 patients. A very good success was reported by 347, a good by 609, a moderate by 181, and none by 21 patients. DRG implementation showed no significant effects. Psychological talking therapy was evaluated as “very good” ( P ≤ .05). With regard to the success of the medical talking and nutrition therapy, there were no significant differences ( P ≥ .05) between the time before and after DRG implementation. Conclusion Broadening conventional medical treatment with CAM practices can lead to a parallel treatment of DRGs in hospitals working with complementary medicine. This results in very patient-centered therapies, which may impact patient satisfaction.

Download Full-text

Muscle strength in hyperthyroid patients before and after medical treatment

Clinical Physiology ◽

10.1111/j.1475-097x.1990.tb00446.x ◽

1990 ◽

Vol 10 (6) ◽

pp. 545-550 ◽

Cited By ~ 12

Author(s):

F. Celsing ◽

S. H. Westing ◽

U. Adamson ◽

B. Ekblom

Keyword(s):

Muscle Strength ◽

Medical Treatment ◽

Before And After ◽

Hyperthyroid Patients

Download Full-text

Treatment Efficacy

Journal of Speech Language and Hearing Research ◽

10.1044/jslhr.4101.s101 ◽

1998 ◽

Vol 41 (1) ◽

Cited By ~ 205

Author(s):

Lorraine Olson Ramig ◽

Katherine Verdolini

Keyword(s):

Medical Treatment ◽

Voice Disorders ◽

Voice Disorder ◽

Future Research ◽

Vocal Health ◽

Physical Conditions ◽

Voice Treatment ◽

Before And After ◽

The Voice

This article reviews the literature on the efficacy of treatment for voice disorders primarily using studies published in peer-reviewed journals. Voice disorders are defined, their frequency of occurrence across the life span is reported, and their impact on the lives of individuals with voice disorders is documented. The goal of voice treatment is to maximize vocal effectiveness given the existing disorder and to reduce the handicapping effect of the voice problem. Voice treatment may be (a) the preferred treatment to resolve the voice disorder when medical (surgical or pharmacological) treatments are not indicated; (b) the initial treatment in cases where medical treatment appears indicated; it may obviate the need for medical treatment; (c) completed before and after surgical treatment to maximize long-term post-surgical voice; and (d) a preventative treatment to preserve vocal health. Experimental and clinical data are reviewed that support these roles applied to various disorder types: (a) vocal misuse, hyperfunction and muscular imbalance (frequently resulting in edema, vocal nodules, polyps or contact ulcers); (b) medical or physical conditions (e.g., laryngeal nerve trauma, Parkinson disease); and (c) psychogenic disorders (e.g., conversion reactions, personality disorders). Directions for future research are suggested which maximize clinical outcomes and scientific rigor to enhance knowledge on the efficacy of voice treatment.

Download Full-text

P366 Relevance of chromogranin A according to disease activity and medical treatment in IBD patients

Journal of Crohn s and Colitis ◽

10.1016/s1873-9946(14)60486-4 ◽

2014 ◽

Vol 8 ◽

pp. S218

Author(s):

S. Vradelis ◽

A. Zissimopoulos ◽

M. Konialis ◽

D. Chadolias ◽

A. Bampali ◽

...

Keyword(s):

Medical Treatment ◽

Disease Activity ◽

Chromogranin A

Download Full-text

Non-Inflammatory Pathologies of Conjunctiva

10.4018/978-1-7998-6937-5.ch004 ◽

2022 ◽

pp. 102-136

Keyword(s):

Medical Treatment ◽

Intraepithelial Neoplasia ◽

Underlying Disease ◽

Surgical Interventions ◽

Anatomical Changes ◽

Before And After ◽

Conjunctival Lymphoma

Non-inflammatory pathologies of conjunctiva refer to conjunctival diseases or conditions that do not have infectious or immune inflammatory origin. This chapter includes disorders such as conjunctivochalasis, conjunctival cysts, conjunctival lymphangiectasias, conjunctival lymphoma, dermoids, papilloma, intraepithelial neoplasia, nevi and other rarely seen tumors, conjunctival degenerations and changes related to aging, xerosis, as well as interesting cases of fastidious conjunctivitis. Some cases of neoplasia have before and after treatment illustration to highlight the possibility of medical treatment against surgical interventions. At the end of this chapter, some observations are added to show the anatomical changes of conjunctiva without any underlying disease or inflammation.

Download Full-text

Increased Chromogranin A Cell Density in the Large Intestine of Patients with Irritable Bowel Syndrome after Receiving Dietary Guidance

Gastroenterology Research and Practice ◽

10.1155/2015/823897 ◽

2015 ◽

Vol 2015 ◽

pp. 1-8 ◽

Cited By ~ 12

Author(s):

Tarek Mazzawi ◽

Doris Gundersen ◽

Trygve Hausken ◽

Magdy El-Salhy

Keyword(s):

Irritable Bowel Syndrome ◽

Cell Density ◽

Large Intestine ◽

Chromogranin A ◽

Endocrine Cells ◽

Common Marker ◽

Before And After ◽

A Cell ◽

Colon And Rectum ◽

Irritable Bowel

The large intestine contains five types of endocrine cells that regulate its functions by sensing its luminal contents and releasing specific hormones. Chromogranin A (CgA) is a common marker for the gastrointestinal endocrine cells, and it is abnormal in irritable bowel syndrome (IBS) patients. Most IBS patients relate their symptoms to certain food elements. The present study investigated the effect of dietary guidance on the total endocrine cells of the large intestine as detected by CgA in 13 IBS patients. Thirteen control subjects were also included. Each patient received three sessions of dietary guidance. Colonoscopies were performed on controls and patients (at baseline and at 3–9 months after receiving guidance). Biopsy samples from the colon and rectum were immunostained for CgA and quantified by computerized image analysis. The densities of CgA cells in the total colon (mean ± SEM) among the controls and the IBS patients before and after receiving dietary guidance were83.3±10.1,38.6±3.7, and64.7±4.2cells/mm2, respectively (P=0.0004), and were unchanged in the rectum. In conclusion, the increase in CgA cell density after receiving dietary guidance may reflect a change in the densities of the large intestinal endocrine cells causing an improvement in the IBS symptoms.

Download Full-text